التفاصيل البيبلوغرافية
| العنوان: |
Targeting a neoantigen derived from a common TP53 mutation. |
| المؤلفون: |
Hsiue, Emily Han-Chung, Wright, Katharine M., Douglass, Jacqueline, Hwang, Michael S., Mog, Brian J., Pearlman, Alexander H., Paul, Suman, DiNapoli, Sarah R., Konig, Maximilian F., Wang, Qing, Schaefer, Annika, Miller, Michelle S., Skora, Andrew D., Azurmendi, P. Aitana, Murphy, Michael B., Liu, Qiang, Watson, Evangeline, Li, Yana, Pardoll, Drew M., Bettegowda, Chetan |
| المصدر: |
Science. 3/5/2021, Vol. 371 Issue 6533, p1009-1009. 1p. 1 Diagram. |
| مصطلحات موضوعية: |
*GENETIC mutation, *TUMOR suppressor genes, *PROTEINS, *IMMUNOGLOBULINS, *HLA histocompatibility antigens |
| مستخلص: |
The article presents the discussion on targeting a neoantigen derived from a common TP53 mutation. Topics include proteins encoded by tumor suppressor genes being inactivated through mutation; intracellular protein located within the nucleus reaching for conventional antibody-based therapies; and proteins being degraded into peptides by the proteasome and a fraction of these peptides presented by the human leukocyte antigen (HLA). |
| قاعدة البيانات: |
Academic Search Index |
