التفاصيل البيبلوغرافية
| العنوان: |
The relationship between immune fitness and saliva biomarkers of systemic inflammation |
| المؤلفون: |
Mulder, Kiki EW, van Oostrom, Evi C., Verheul, Marjolijn CE, Hendriksen, Pauline A., Thijssen, Suzan, Diks, Mara AP, Kraneveld, Aletta D., Garssen, Johan, Verster, Joris C. |
| المساهمون: |
Afd Pharmacology, Pharmacology |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Assessment, c-reactive protein, Cytokines, Immune fitness, Immunoglobulin A, Sex differences, Nephrology |
| الوصف: |
Purpose: It is vital that Immune fitness, i.e., how well the immune system functions and reacts to challenges, can be reliably be examined. The current study aimed to compare immune fitness with assessments of saliva biomarkers of systemic inflammation. Methods: N = 108 healthy young adults (18–30-year-old students of Utrecht University, the Netherlands) participated in the study. A saliva sample was collected for biomarker assessment (Interleukin (IL)-1β, IL-6, IL-8, IL-10, immunoglobulin A (IgA), and tumor necrosis factor-alpha (TNF-α), and c-reactive protein (CRP). Additionally, a survey was completed to assess immune fitness, mood, mental resilience, and quality of life. The correlations between the biomarker assessments, immune fitness and mood were determined. Results: No significant correlations between immune fitness and biomarkers of systemic inflammation were found. Significant sex differences in correlations with immune fitness were demonstrated for loneliness (significant only in men) and fatigue (significant only in women). For both sexes, immune fitness correlated significantly with anxiety, mental resilience, and quality of life. Conclusion: No significant correlations were found between immune fitness and saliva biomarkers of systemic inflammation. Immune fitness correlated significantly with anxiety, mental resilience, and quality of life. Sex differences were demonstrated in the relation of immune fitness with loneliness and fatigue. Future research should further investigate factors that may influence the relationship between immune fitness, mood, and biomarkers of systemic inflammation, including underlying psychological mechanisms of possible sex differences. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2666-3546 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/435516Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/435516Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.BF84B01F |
| قاعدة البيانات: |
BASE |
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