التفاصيل البيبلوغرافية
| العنوان: |
DataSheet_1_Bispecific antibodies tethering innate receptors induce human tolerant-dendritic cells and regulatory T cells.docx |
| المؤلفون: |
Lucille Lamendour, Mäelle Gilotin, Nora Deluce-Kakwata Nkor, Zineb Lakhrif, Daniel Meley, Anne Poupon, Thibaut Laboute, Anne di Tommaso, Jean-Jacques Pin, Denis Mulleman, Guillaume Le Mélédo, Nicolas Aubrey, Hervé Watier, Florence Velge-Roussel |
| سنة النشر: |
2024 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, human dendritic cell, innate receptors, type C lectin, TLR2, bispecific antibody, tolerant dendritic cell, interleukine-10, TGF-β1 |
| الوصف: |
There is an urgent need for alternative therapies targeting human dendritic cells (DCs) that could reverse inflammatory syndromes in many autoimmune and inflammatory diseases and organ transplantations. Here, we describe a bispecific antibody (bsAb) strategy tethering two pathogen-recognition receptors at the surface of human DCs. This cross-linking switches DCs into a tolerant profile able to induce regulatory T-cell differentiation. The bsAbs, not parental Abs, induced interleukin 10 and transforming growth factor β1 secretion in monocyte-derived DCs and human peripheral blood mononuclear cells. In addition, they induced interleukin 10 secretion by synovial fluid cells in rheumatoid arthritis and gout patients. This concept of bsAb-induced tethering of surface pathogen-recognition receptors switching cell properties opens a new therapeutic avenue for controlling inflammation and restoring immune tolerance. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/DataSheet_1_Bispecific_antibodies_tethering_innate_receptors_induce_human_tolerant-dendritic_cells_and_regulatory_T_cells_docx/25488184Test |
| DOI: |
10.3389/fimmu.2024.1369117.s001 |
| الإتاحة: |
https://doi.org/10.3389/fimmu.2024.1369117.s001Test
https://figshare.com/articles/dataset/DataSheet_1_Bispecific_antibodies_tethering_innate_receptors_induce_human_tolerant-dendritic_cells_and_regulatory_T_cells_docx/25488184Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.8A2E30CE |
| قاعدة البيانات: |
BASE |
