Unique and specific Agrobacterium diversity in urinary microbiota of tolerant kidney transplanted recipients
| العنوان: | Unique and specific Agrobacterium diversity in urinary microbiota of tolerant kidney transplanted recipients |
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| المؤلفون: | Colas, Luc, Mongodin, Emmanuel, Montassier, Emmanuel, Chesneau, Mélanie, Guérif, Pierrick, Hittle, Lauren, Giral, Magali, Bromberg, Jonathan, Brouard, Sophie, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Cesbron, Anne, Chapelet, Agnès, Dantal, Jacques, Delbos, Florent, Deltombe, Clement, Devis, Anne, Figueres, Lucile, Garandeau, Claire, Gourraud‐Vercel, Caroline, Hourmant, Maryvonne, Kandell, Christine, Karam, Georges, Kerleau, Clarisse, Meurette, Aurelie, Moreau, Anne, Renaudin, Karine, Ville, Simon, Walencik, Alexandre |
| المساهمون: | unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Dynamique cellulaire et moléculaire de la muqueuse respiratoire, Université de Reims Champagne-Ardenne (URCA)-IFR53-Institut National de la Santé et de la Recherche Médicale (INSERM), Thérapeutiques cliniques et expérimentales des infections (EA 3826) (EA 3826), Université de Nantes (UN)-Université de Nantes (UN), Institute of Transplantation Urology and Nephrology [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Immunointervention dans les allo et xénotransplantations, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM)-ITUN, Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Etablissement Français du Sang [Nantes], Service de Néphrologie et Immunologie Clinique, Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôtel Dieu, Développement du Systeme Immunitaire, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'urologie, Hôtel-Dieu, Institut de Mathématiques de Jussieu (IMJ), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), This work was carried out with the support of CENTAURE foundation grants, a Roche Organ Transplantation Research Foundation and European Society for Organ Transplantation grant, and under the auspices of the IHU‐Cesti project, which received French government financial support managed by the National Research Agency via the 'Investment Into The Future' program (ANR‐10‐IBHU‐005). The IHU‐Cesti project is also supported by Nantes Metropole and the Pays de la Loire Region. This work was also supported by the Labex IGO project (ANR‐11‐LABX‐0016‐01) funded by the Investissements d'Avenir French Government program, managed by the French National Research Agency., Le Bihan, Sylvie, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Hôtel Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes) |
| المصدر: | American Journal of Transplantation American Journal of Transplantation, Wiley, 2019, ⟨10.1111/ajt.15549⟩ American Journal of Transplantation, 2019, ⟨10.1111/ajt.15549⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Graft Rejection, Male, medicine.medical_specialty, translational research/science, Urinary system, kidney transplantation/nephrology, immunosuppression/immune modulation, 030230 surgery, clinical research/practice, Organ transplantation, 03 medical and health sciences, 0302 clinical medicine, Immune system, Risk Factors, RNA, Ribosomal, 16S, Proteobacteria, Immune Tolerance, medicine, Humans, Immunology and Allergy, Pharmacology (medical), Microbiome, Kidney transplantation, Transplantation, Kidney, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, tolerance, biology, business.industry, Graft Survival, Biodiversity, Middle Aged, Prognosis, medicine.disease, biology.organism_classification, Kidney Transplantation, 3. Good health, Calcineurin, medicine.anatomical_structure, Case-Control Studies, Immunology, Female, business, microbiomics, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Follow-Up Studies |
| الوصف: | International audience; Host‐microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), minimally immunosuppressed (n = 19), and spontaneously tolerant (n = 16) patients, paired with age‐matched controls (n = 27) were profiled and compared to each other at a taxonomic level with special interest in the immunosuppressive regimen. All comparisons and correlations were adjusted on sex and time posttransplantation. Our results highlighted a unique and specific urinary microbiota associated with spontaneous tolerance characterized by a high diversity and a clear Proteobacteria profile. Finally, we report that this profile is (1) impacted by gender, (2) inversely correlated with immunosuppressive drugs (calcineurin inhibitors and mammalian target of rapamycin inhibitors), and (3) stable in time. |
| اللغة: | English |
| تدمد: | 1600-6135 1600-6143 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469a813d5cf0d747f8e38da5fcf87987Test https://www.hal.inserm.fr/inserm-02285840Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....469a813d5cf0d747f8e38da5fcf87987 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16006135 16006143 |
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