دورية أكاديمية
Ester-linked ubiquitination by HOIL-1 controls immune signalling by shaping the linear ubiquitin landscape
| العنوان: | Ester-linked ubiquitination by HOIL-1 controls immune signalling by shaping the linear ubiquitin landscape |
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| المؤلفون: | Pruneda, Jonathan N., Damgaard, Rune Busk |
| المصدر: | Pruneda , J N & Damgaard , R B 2021 , ' Ester-linked ubiquitination by HOIL-1 controls immune signalling by shaping the linear ubiquitin landscape ' , FEBS Journal , vol. 288 , no. 20 , pp. 5903-5908 . https://doi.org/10.1111/febs.16118Test |
| سنة النشر: | 2021 |
| المجموعة: | Technical University of Denmark: DTU Orbit / Danmarks Tekniske Universitet |
| مصطلحات موضوعية: | HOIL-1, Immune signalling, Inflammation, LUBAC, Ubiquitin |
| الوصف: | Ester-linked ubiquitination of serine or threonine residues - or even lipids - has emerged as a new regulatory earmark in cell signalling. Petrova et al. (2021) now reveal that ubiquitin esterification by the atypical ubiquitin ligase HOIL-1, a component of the LUBAC complex, is critical for proper formation of linear ubiquitin chains and control of immune signalling in T cells and macrophages. Surprisingly, ester-linked ubiquitination can either promote or inhibit linear ubiquitin conjugation and cytokine production depending on the receptor and immune cell engaged. Comment on: https://doi.org/10.1111/febs.15896Test. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://orbit.dtu.dk/en/publications/75de8f7a-283f-4c2f-b9ba-5a91f73a3a1fTest |
| DOI: | 10.1111/febs.16118 |
| الإتاحة: | https://doi.org/10.1111/febs.16118Test https://orbit.dtu.dk/en/publications/75de8f7a-283f-4c2f-b9ba-5a91f73a3a1fTest |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.C8A7B1DD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/febs.16118 |
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