التفاصيل البيبلوغرافية
| العنوان: |
Viral miRNAs and immune evasion. |
| المؤلفون: |
Boss, Isaac W., Renne, Rolf |
| المصدر: |
BBA - Gene Regulatory Mechanisms; Nov2011, Vol. 1809 Issue 11/12, p708-714, 7p |
| مصطلحات موضوعية: |
NON-coding RNA, GENE expression, GENETIC regulation, VIRUS diseases, IMMUNE response, VIRAL genomes, GENETIC code |
| مستخلص: |
Abstract: Viral miRNAs, ~22nt RNA molecules which post-transcriptionally regulate gene expression, are emerging as important tools in immune evasion. Viral infection is a complex process that requires immune evasion in order to establish persistent life-long infection of the host. During this process viruses express both protein-coding and non-coding genes, which help to modulate the cellular environment making it more favorable for infection. In the last decade, it was uncovered that DNA viruses express a diverse and abundant pool of small non-coding RNA molecules, called microRNAs (miRNAs). These virally encoded miRNAs are non-immunogenic and therefore are important tools used to evade both innate and adaptive immune responses. This review aims to summarize our current knowledge of herpesvirus- and polyomavirus-encoded miRNAs, and how they contribute to immune evasion by targeting viral and/or host cellular genes. This article is part of a Special Issue entitled: MicroRNAs in viral gene regulation. [Copyright &y& Elsevier] |
|
Copyright of BBA - Gene Regulatory Mechanisms is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
