دورية أكاديمية
Strategies for clinical dose optimization of T cell-engaging therapies in oncology
| العنوان: | Strategies for clinical dose optimization of T cell-engaging therapies in oncology |
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| المؤلفون: | Kathryn Ball, Simon J Dovedi, Pavan Vajjah, Alex Phipps |
| المصدر: | mAbs, Vol 15, Iss 1 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | T-cell engager, immune oncology, bispecific antibody, dose optimization, quantitative clinical pharmacology, translational PK/PD modeling, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | ABSTRACTInnovative approaches in the design of T cell-engaging (TCE) molecules are ushering in a new wave of promising immunotherapies for the treatment of cancer. Their mechanism of action, which generates an in trans interaction to create a synthetic immune synapse, leads to complex and interconnected relationships between the exposure, efficacy, and toxicity of these drugs. Challenges thus arise when designing optimal clinical dose regimens for TCEs with narrow therapeutic windows, with a variety of dosing strategies being evaluated to mitigate key side effects such as cytokine release syndrome, neurotoxicity, and on-target off-tumor toxicities. This review evaluates the current approaches to dose optimization throughout the preclinical and clinical development of TCEs, along with perspectives for improvement of these strategies. Quantitative approaches used to aid the understanding of dose-exposure-response relationships are highlighted, along with opportunities to guide the rational design of next-generation TCE molecules, and optimize their dose regimens in patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 19420862 1942-0870 1942-0862 |
| العلاقة: | https://doaj.org/toc/1942-0862Test; https://doaj.org/toc/1942-0870Test |
| DOI: | 10.1080/19420862.2023.2181016 |
| الوصول الحر: | https://doaj.org/article/3e72b1cc99f146d7aaec4efa9cd6c54cTest |
| رقم الانضمام: | edsdoj.3e72b1cc99f146d7aaec4efa9cd6c54c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19420862 19420870 |
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| DOI: | 10.1080/19420862.2023.2181016 |