دورية أكاديمية
Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet
| العنوان: | Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet |
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| المؤلفون: | Martín Masot, Rafael, Jiménez-Muñoz, María, Herrador-López, Marta, Navas-López, Víctor Manuel, Obis Monné, Èlia, Jové Font, Mariona, Pamplona Gras, Reinald, Nestares, Teresa |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Universitat de Lleida: Repositori Obert UdL |
| مصطلحات موضوعية: | Celiac disease, Gluten-free diet, Metabolomics, Children, Immune, Intestinal |
| الوصف: | Celiac disease (CD) is included in the group of complex or multifactorial diseases, i.e., those caused by the interaction of genetic and environmental factors. Despite a growing understanding of the pathophysiological mechanisms of the disease, diagnosis is still often delayed and there are no effective biomarkers for early diagnosis. The only current treatment, a gluten-free diet (GFD), can alleviate symptoms and restore intestinal villi, but its cellular effects remain poorly understood. To gain a comprehensive understanding of CD’s progression, it is crucial to advance knowledge across various scientific disciplines and explore what transpires after disease onset. Metabolomics studies hold particular significance in unravelling the complexities of multifactorial and multisystemic disorders, where environmental factors play a significant role in disease manifestation and progression. By analyzing metabolites, we can gain insights into the reasons behind CD’s occurrence, as well as better comprehend the impact of treatment initiation on patients. In this review, we present a collection of articles that showcase the latest breakthroughs in the field of metabolomics in pediatric CD, with the aim of trying to identify CD biomarkers for both early diagnosis and treatment monitoring. These advancements shed light on the potential of metabolomic analysis in enhancing our understanding of the disease and improving diagnostic and therapeutic strategies. More studies need to be designed to cover metabolic profiles in subjects at risk of developing the disease, as well as those analyzing biomarkers for follow-up treatment with a GFD. ; This research was funded by the FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades Projects FEDER No B-AGR-658 and Excelencia P21_00101. It was also partially funded with the grant “Investigation grant program by the Association of Celiacs and Sensitive to Gluten of the Community of Madrid” and the Government of Catalonia: Agency for ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6643 |
| العلاقة: | Reproducció del document publicat a https://doi.org/10.3390/nu15132871Test; Nutrients, 2023, vol. 15, núm. 13, 2871; https://doi.org/10.3390/nu15132871Test; https://repositori.udl.cat/handle/10459.1/464243Test |
| DOI: | 10.3390/nu15132871 |
| الإتاحة: | https://doi.org/10.3390/nu15132871Test https://repositori.udl.cat/handle/10459.1/464243Test |
| حقوق: | cc-by (c) Rafael Martín-Masot et al., 2023 ; Attribution 4.0 International ; info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.5775A5F7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726643 |
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| DOI: | 10.3390/nu15132871 |