التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of FLT-PET-CT as an imaging biomarker of proliferation in primary breast cancer. |
| المؤلفون: |
Woolf, D K, Beresford, M, Li, S P, Dowsett, M, Sanghera, B, Wong, W L, Sonoda, L, Detre, S, Amin, V, Ah-See, M-L, Miles, D, Makris, A |
| المصدر: |
British Journal of Cancer; 6/10/2014, Vol. 110 Issue 12, p2847-2854, 8p |
| مصطلحات موضوعية: |
IMAGING of cancer, BIOMARKERS, CANCER cell proliferation, EARLY detection of cancer, BREAST cancer research, CANCER chemotherapy |
| مستخلص: |
Background:[18F]fluorothymidine (FLT) has been proposed as a positron emission tomography (PET)-imaging biomarker of proliferation for breast cancer. The aim of this prospective study was to assess the feasibility of FLT-PET-CT as a technique for predicting the response to neoadjuvant chemotherapy (NAC) in primary breast cancer and to compare baseline FLT with Ki-67.Methods:Twenty women with primary breast cancer had a baseline FLT-PET-CT scan that was repeated before the second cycle of chemotherapy. Expression of Ki-67 in the diagnostic biopsy was quantified. From the FLT-PET-CT scans lesion maximum and mean standardised uptake values (SUVmax, SUVmean) were calculated.Results:Mean baseline SUVmax was 7.3, and 4.62 post one cycle of NAC, representing a drop of 2.68 (36.3%). There was no significant association between baseline, post chemotherapy, or change in SUVmax and pathological response to NAC. There was a significant correlation between pre-chemotherapy Ki-67 and SUVmax of 0.604 (P=0.006).Conclusions:Baseline SUVmax measurements of FLT-PET-CT were significantly related to Ki-67 suggesting that it is a proliferation biomarker. However, in this series neither the baseline value nor the change in SUVmax after one cycle of NAC were able to predict response as most patients had a sizeable SUVmax reduction. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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