التفاصيل البيبلوغرافية
| العنوان: |
Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis. |
| المؤلفون: |
Zheng, J.-N., Pei, D.-S., Mao, L.-J., Liu, X.-Y., Sun, F.-H., Zhang, B.-F., Liu, Y.-Q., Liu, J.-J., Li, W., Han, D. |
| المصدر: |
Cancer Gene Therapy; Jan2010, Vol. 17 Issue 1, p28-36, 9p, 1 Black and White Photograph, 1 Diagram, 4 Graphs |
| مصطلحات موضوعية: |
ADENOVIRUSES, INTERLEUKINS, NEOVASCULARIZATION, MELANOMA, GENETIC transformation |
| مستخلص: |
It has been shown that interleukin 18 (IL-18) exerts antitumor activity. In this study, we investigated whether oncolytic adenovirus-mediated gene transfer of IL-18 could induce strong antitumor activity. A tumor-selective replicating adenovirus expressing IL-18 (ZD55-IL-18) was constructed by insertion of an IL-18 expression cassette into the ZD55 vector, which is based on deletion of the adenoviral E1B 55-kDa gene. It has been shown that ZD55-IL-18 exerted a strong cytopathic effect and significant apoptosis in tumor cells. ZD55-IL-18 significantly decreased vascular endothelial growth factor and CD34 expression in the melanoma cells. Treatment of established tumors with ZD55-IL-18 showed much stronger antitumor activity than that induced by ZD55-EGFP (enhanced green fluorescent protein) or Ad-IL-18. These data indicated that oncolytic adenovirus expressing IL-18 could exert potential antitumor activity through inhibition of angiogenesis and offer a novel approach to melanoma therapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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