دورية أكاديمية
IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα
| العنوان: | IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα |
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| المؤلفون: | Shekhar, Tanmay M., Miles, Mark A., Gupte, Ankita, Taylor, Scott, Tascone, Brianna, Walkley, Carl R., Hawkins, Christine J. |
| بيانات النشر: | Impact Journals LLC |
| سنة النشر: | 2016 |
| المجموعة: | Australian Catholic University: ACU Research Bank |
| مصطلحات موضوعية: | IAP, Smac, bone cancer, RIP1, osteosarcoma |
| الوصف: | Outcomes for patients diagnosed with the bone cancer osteosarcoma have not improved significantly in the last four decades. Only around 60% of patients and about a quarter of those with metastatic disease survive for more than five years. Although DNA-damaging chemotherapy drugs can be effective, they can provoke serious or fatal adverse effects including cardiotoxicity and therapy-related cancers. Better and safer treatments are therefore needed. We investigated the anti-osteosarcoma activity of IAP antagonists (also known as Smac mimetics) using cells from primary and metastatic osteosarcomas that arose spontaneously in mice engineered to lack p53 and Rb expression in osteoblast-derived cells. The IAP antagonists SM-164, GDC-0152 and LCL161, which efficiently target XIAP and cIAPs, sensitized cells from most osteosarcomas to killing by low levels of TNFα but not TRAIL. RIPK1 expression levels and activity correlated with sensitivity. RIPK3 levels varied considerably between tumors and RIPK3 was not required for IAP antagonism to sensitize osteosarcoma cells to TNFα. IAP antagonists, including SM-164, lacked mutagenic activity. These data suggest that drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFα, and would be unlikely to provoke therapy-induced cancers in osteosarcoma survivors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| تدمد: | 1949-2553 |
| العلاقة: | https://acuresearchbank.acu.edu.au/item/85zv4/iap-antagonists-sensitize-murine-osteosarcoma-cells-to-killing-by-tnfTest; https://acuresearchbank.acu.edu.au/download/7a626494e0bd2f3f85b85d0c3c763472ba95a5fe462bc0d813dbdb6f355ffa43/8721639/OA_Shekhar_2016_IAP_antagonists_sensitize_murine_osteosarcoma_cells.pdfTest; https://doi.org/10.18632/oncotarget.8980Test; Shekhar, Tanmay M., Miles, Mark A., Gupte, Ankita, Taylor, Scott, Tascone, Brianna, Walkley, Carl R. and Hawkins, Christine J. (2016). IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα. Oncotarget. 7(23), pp. 33866 - 33886. https://doi.org/10.18632/oncotarget.8980Test |
| DOI: | 10.18632/oncotarget.8980 |
| الإتاحة: | https://doi.org/10.18632/oncotarget.8980Test https://acuresearchbank.acu.edu.au/download/7a626494e0bd2f3f85b85d0c3c763472ba95a5fe462bc0d813dbdb6f355ffa43/8721639/OA_Shekhar_2016_IAP_antagonists_sensitize_murine_osteosarcoma_cells.pdfTest |
| رقم الانضمام: | edsbas.2899AB75 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19492553 |
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| DOI: | 10.18632/oncotarget.8980 |