دورية أكاديمية
Autoimmune and inflammatory diseases associated with chronic myelomonocytic leukemia: A series of 26 cases and literature review
| العنوان: | Autoimmune and inflammatory diseases associated with chronic myelomonocytic leukemia: A series of 26 cases and literature review |
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| المؤلفون: | Grignano, Eric, Mekinian, Arsene, Braun, Thorsten, Liozon, Eric, Hamidou, Mohamed, Decaux, Olivier, Puechal, Xavier, Kahn, Jean-Emmanuel, Schoindre, Yoland, Rossignol, Julien, Lortholary, Olivier, Lioger, Bertrand, Hermine, Olivier, Park, Sophie, Ades, Lionel, Montestruc, François, Ricard, Laure, Gardin, Claude, Fenaux, Pierre, Fain, Olivier |
| المساهمون: | CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Avicenne AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Médecine interne A et polyclinique médicale CHU Limoges, CHU Limoges, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Hôpital Cochin AP-HP, Hôpital Foch Suresnes, Hôpital Necker - Enfants Malades AP-HP, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service d'immuno-hématologie pédiatrique CHU Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP, Centre Hospitalier Universitaire CHU Grenoble (CHUGA), CHU Saint Louis, eXYSTAT Malakoff, Service greffe de moelle osseuse, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, We thank the French National Society of Internal Medicine, the Club Rhumatismes et Inflammation and the Groupe Francophone des Myélodysplasies for their help in the organization of this study. We thank Catherine Henry (Service de cytogénétique, CHU de Rennes, Rennes) for help in characterizing bone-marrow karyotypes for some cases. |
| المصدر: | ISSN: 0145-2126. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Chronic myelomonocytic leukemia, Autoimmune diseases, Vasculitis, Immunosuppressive agents, Hypomethylating agents, Outcome, [SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | International audience ; We wanted to describe the characteristics, treatment and outcome of autoimmune and inflammatory diseases (SAIDs) associated with chronic myelomonocytic leukemia (CMML), and conducted a French multicenter retrospective study and a literature review. We included 26 cases of CMML (median age 75 years, 54% female), 80% with CMML-1. CPSS score was low (0 or 1) in 75% of cases. SAIDS was systemic vasculitis in 54%. Diagnosis of the 2 diseases was concomitant in 31% cases, and CMML was diagnosed before SAIDs in 12 cases (46%). First line treatment for SAIDs consisted mostly of steroid, with 85% of response. Second-line treatment was needed in 40% cases. Six patients received hypomethylating agents, with 66% response on SAIDs. A literature review found 49 cases of CMML-associated SAIDs, in whom SAIDs was systemic vasculitis in 29% cases.Hence, vasculitis is the most frequent SAIDs associated with CMML. After initial response to steroids, recurrence and steroid-dependence were frequent. Hypomethylating agents may be interesting in this context. © 2016 Elsevier Ltd. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27337291; hal-01388084; https://hal.science/hal-01388084Test; https://hal.science/hal-01388084/documentTest; https://hal.science/hal-01388084/file/Autoimmune%20and%20inflammatory%20diseases.pdfTest; PUBMED: 27337291 |
| DOI: | 10.1016/j.leukres.2016.05.013 |
| الإتاحة: | https://doi.org/10.1016/j.leukres.2016.05.013Test https://hal.science/hal-01388084Test https://hal.science/hal-01388084/documentTest https://hal.science/hal-01388084/file/Autoimmune%20and%20inflammatory%20diseases.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.78ABFB0A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.leukres.2016.05.013 |
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