التفاصيل البيبلوغرافية
| العنوان: |
Cost-Effectiveness of Sensor-Augmented Pump Therapy with Low Glucose Suspend Versus Standard Insulin Pump Therapy in Two Different Patient Populations with Type 1 Diabetes in France. |
| المؤلفون: |
Roze, Stéphane1, Smith-Palmer, Jayne2, Valentine, William2, Payet, Vincent3, de Portu, Simona4, Papo, Natalie4, Cucherat, Michel5, Hanaire, Helene6, Roze, Stéphane7 (AUTHOR) |
| المصدر: |
Diabetes Technology & Therapeutics. Feb2016, Vol. 18 Issue 2, p75-84. 10p. |
| مصطلحات موضوعية: |
*INSULIN pumps, *INSULIN therapy, *PEOPLE with diabetes, *TREATMENT of diabetes, *GLUCOSE, *BLOOD sugar analysis, *HYPOGLYCEMIC agents, *BLOOD sugar monitoring, *COMPARATIVE studies, *COST effectiveness, *GLYCOSYLATED hemoglobin, *HYPERGLYCEMIA, *HYPOGLYCEMIA, *TYPE 1 diabetes, *LIFE expectancy, *RESEARCH methodology, *MEDICAL cooperation, *QUALITY of life, *RESEARCH, *EVALUATION research, *QUALITY-adjusted life years, *ECONOMICS, *DIAGNOSIS |
| مصطلحات جغرافية: |
FRANCE |
| مستخلص: |
Background: Sensor-augmented pump therapy (SAP) provides a useful adjunct relative to continuous subcutaneous insulin infusion (CSII) alone. It can provide early warning of the onset of hyperglycemia and hypoglycemia and has the functionality to suspend insulin delivery if sensor glucose levels fall below a predefined threshold. The aim was to assess the cost-effectiveness of SAP with low glucose suspend (LGS) versus CSII alone in type 1 diabetes.Materials and Methods: Cost-effectiveness analysis was performed using the CORE Diabetes Model, using published clinical input data. The analysis was performed in two cohorts: one with uncontrolled glycated hemoglobin at baseline and one at elevated risk for hypoglycemic events. The analysis was conducted from a healthcare payer perspective over a lifetime time horizon; future costs and clinical outcomes were discounted at 4% per annum.Results: In patients with uncontrolled glycated hemoglobin at baseline, SAP + LGS resulted in improved discounted quality-adjusted life expectancy (QALE) versus CSII (10.55 quality-adjusted life-years [QALYs] vs. 9.36 QALYs) but higher mean lifetime direct costs (€84,972 vs. €49,171) resulting in an incremental cost-effectiveness ratio (ICER) of €30,163 per QALY gained. In patients at elevated risk for hypoglycemia, the ICER was €22,005 per QALY gained for SAP + LGS versus CSII as lifetime costs were higher (€88,680 vs. €57,097), but QALE was also higher (18.46 QALYs vs. 18.30 QALYs).Conclusions: In France, projected improvements in outcomes with SAP + LGS versus CSII translated into an ICER generally considered as good value for money, particularly in patients who experience frequent and/or problematic hypoglycemic events. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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