دورية أكاديمية
Time Spent in Hypoglycemia According to Age and Time of Day: Observations During Closed-Loop Insulin Delivery.
| العنوان: | Time Spent in Hypoglycemia According to Age and Time of Day: Observations During Closed-Loop Insulin Delivery. |
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| المؤلفون: | Alwan, Heba, Ware, Julia, Boughton, Charlotte K, Wilinska, Malgorzata E, Allen, Janet M, Lakshman, Rama, Nwokolo, Munachiso, Hartnell, Sara, Bally, Lia, de Beaufort, Carine, Besser, Rachel EJ, Campbell, Fiona M, Davis, Nikki, Denvir, Louise, Evans, Mark L, Fröhlich-Reiterer, Elke, Ghatak, Atrayee, Hofer, Sabine E, Kapellen, Thomas M, Leelarathna, Lalantha, Mader, Julia K, Narendran, Parth, Rami-Mehrar, Birgit, Tauschmann, Martin, Thabit, Hood, Thankamony, Ajay, Hovorka, Roman |
| بيانات النشر: | Mary Ann Liebert Inc Department of Paediatrics //dx.doi.org/10.1089/dia.2023.0061 Diabetes Technol Ther |
| سنة النشر: | 2023 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Artificial pancreas, Closed-loop insulin delivery, Insulin pump therapy, Randomized trial, Type 1 diabetes, Adolescent, Aged, Child, Preschool, Humans, Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 1, Hypoglycemia, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Regular, Human, Retrospective Studies, Treatment Outcome, Young Adult, Adult, Middle Aged |
| الوصف: | Objective: We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age group and time of day. Methods: We retrospectively analyzed data from hybrid closed-loop studies involving young children (2-7 years), children and adolescents (8-18 years), adults (19-59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia <3.9 mmol/L (<70 mg/dL). Eight weeks of data for 88 participants were analyzed. Results: Median time spent in hypoglycemia over the 24-h period was highest in children and adolescents (4.4% [interquartile range 2.4-5.0]) and very young children (4.0% [3.4-5.2]), followed by adults (2.7% [1.7-4.0]), and older adults (1.8% [1.2-2.2]); P < 0.001 for difference between age groups. Time spent in hypoglycemia during nighttime (midnight-05:59) was lower than during daytime (06:00-23:59) across all age groups. Conclusion: Time in hypoglycemia was highest in the pediatric age group during closed-loop insulin delivery. Hypoglycemia burden was lowest overnight across all age groups. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/msword |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/350613Test; https://doi.org/10.17863/CAM.97045Test |
| DOI: | 10.17863/CAM.97045 |
| الإتاحة: | https://doi.org/10.17863/CAM.97045Test https://www.repository.cam.ac.uk/handle/1810/350613Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.97462A50 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.97045 |
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