دورية أكاديمية
Investigation of metal-binding metallothioneins in the tissues of rats after oral intake of cinnabar
| العنوان: | Investigation of metal-binding metallothioneins in the tissues of rats after oral intake of cinnabar |
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| المؤلفون: | Zhuang,ZX, Lee,FSC, Shen,JC, Huang,ZY, Wang,XR, 庄峙厦 |
| المصدر: | http://dx.doi.org/10.1007/s00216-004-2624-zTest. |
| سنة النشر: | 2004 |
| المجموعة: | Xiamen University Institutional Repository |
| مصطلحات موضوعية: | HPLC-ICP-MS, HYPHENATED TECHNIQUES, MERCURY, METABOLISM, EXPOSURE, LIVER, MICE |
| الوصف: | The multi-metal-binding MT fractions in rat tissues after oral intake of cinnabar were characterized by hyphenated size-exclusion chromatography (SEC) and inductively coupled plasma mass spectrometry (ICP-MS). With the increase of both the feeding time and dosage of cinnabar the amounts of Hg-binding MT fractions in rat kidney of groups fed cinnabar increased significantly compared with the control group. Meanwhile, more Cu-binding MT were synthesized in the rat kidney, which confirmed the manipulating effect of MT in the homeostasis of Cu for detoxification of nephritic mercury. Although the Hg-binding MT fractions in rat liver of all cinnabar groups were almost independent of cinnabar dosage (2.5-5.0 g kg(-1) bw) and feeding time (2-4 weeks), the amount was much higher than that of the control group. The amounts of Hg-MT in other rat tissues of the cinnabar groups and the control group were compared and their significance is discussed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1618-2642 |
| العلاقة: | Analytical and Bioanalytical Chemistry, 2004,379(3):427-432; WOS:000221674100022; http://dspace.xmu.edu.cn/handle/2288/61809Test |
| الإتاحة: | https://doi.org/10.1007/s00216-004-2624-zTest http://dspace.xmu.edu.cn/handle/2288/61809Test |
| رقم الانضمام: | edsbas.8C7BBE83 |
| قاعدة البيانات: | BASE |
| تدمد: | 16182642 |
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