التفاصيل البيبلوغرافية
| العنوان: |
Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects |
| المؤلفون: |
Olivier Rouyer, Cyril Auger, Anne-Laure Charles, Samy Talha, Alain Meyer, Francois Piquard, Emmanuel Andres, Valerie Schini-Kerth, Bernard Geny |
| المصدر: |
Journal of Clinical Medicine; Volume 8; Issue 6; Pages: 859 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
high-fat meal, flow-mediated dilatation, endothelial function, hypertriglyceridemia, inflammation, oxidative stress, glycemia, polyphenols, juice, champagne |
| الوصف: |
Endothelial dysfunction (ED), often linked to hypertriglyceridemia, is an early step of atherosclerosis. We investigated, in a randomized cross-over study, whether high-fat meal (HFM)-induced ED might be reduced by fruit juice or champagne containing polyphenols. Flow-mediated dilatation (FMD) and biological parameters (lipid profile, glycemia, inflammation, and oxidative stress markers) were determined before and two and three hours after the HFM in 17 healthy young subjects (24.6 ± 0.9 years) drinking water, juice, or champagne. Considering the entire group, despite significant hypertriglyceridemia (from 0.77 ± 0.07 to 1.41 ± 0.18 mmol/L, p < 0.001) and a decrease in Low Density Lipoprotein (LDL), the FMD was not impaired. However, the FMD decreased in 10 subjects (from 10.73 ± 0.95 to 8.13 ± 0.86 and 8.07 ± 1.16%; p < 0.05 and p < 0.01; 2 and 3 h, respectively, after the HFM), without concomitant change in concentration reactive protein or reactive oxygen species, but with an increase in glycemia. In the same subjects, the FMD did not decrease when drinking juice or champagne. In conclusion, HFM can impair the endothelial function in healthy young subjects. Fruit juice, rich in anthocyanins and procyanidins, or champagne, rich in simple phenolic acids, might reduce such alterations, but further studies are needed to determine the underlying mechanisms, likely involving polyphenols. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Hematology; https://dx.doi.org/10.3390/jcm8060859Test |
| DOI: |
10.3390/jcm8060859 |
| الإتاحة: |
https://doi.org/10.3390/jcm8060859Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.654CA6BB |
| قاعدة البيانات: |
BASE |
