التفاصيل البيبلوغرافية
| العنوان: |
Acute kidney injury in critically ill children and 5-year hypertension. |
| المؤلفون: |
Hessey, Erin, Perreault, Sylvie, Roy, Louise, Dorais, Marc, Samuel, Susan, Phan, Véronique, Lafrance, Jean-Philippe, Zappitelli, Michael |
| المصدر: |
Pediatric Nephrology; Jun2020, Vol. 35 Issue 6, p1097-1107, 11p, 2 Diagrams, 3 Charts, 1 Graph |
| مصطلحات موضوعية: |
ACUTE kidney failure, ALGORITHMS, CONFIDENCE intervals, CRITICALLY ill, HYPERTENSION, INTENSIVE care units, LONGITUDINAL method, PATIENTS, DISCHARGE planning, DISEASE prevalence, RETROSPECTIVE studies, DESCRIPTIVE statistics, CHILDREN |
| مصطلحات جغرافية: |
CANADA |
| مستخلص: |
Background: To develop a pediatric-specific hypertension algorithm using administrative data and use it to evaluate the association between acute kidney injury (AKI) in the intensive care unit (ICU) and hypertension diagnosis 5 years post-discharge. Methods: Two-center retrospective cohort study of children (≤ 18 years old) admitted to the pediatric ICU in Montreal, Canada, between 2003 and 2005 and followed until 2010. Patients with a valid healthcare number and without end-stage renal disease were included. Patients who could not be merged with the provincial database, did not survive admission, underwent cardiac surgery, had pre-existing renal disease associated with hypertension or a prior diagnosis of hypertension were excluded. AKI defined using the Kidney Disease: Improving Global Outcomes (KDIGO) definition. Using diagnostic codes and medications from administrative data, novel pediatric-specific hypertension definitions were designed. Both the evaluation of the prevalence of hypertension diagnosis and the association between AKI and hypertension occurred. Results: Nineteen hundred and seventy eight patients were included (median age at admission [interquartile range] 4.3 years [1.1–11.8], 44% female, 325 (16.4%) developed AKI). Of these patients, 130 (7%) had a hypertension diagnosis 5 years after discharge. Patients with AKI had a higher prevalence of hypertension diagnosis [non-AKI: 84/1653 (5.1%) vs. AKI: 46/325 (14.2%), p <.001]. Children with AKI had a higher adjusted risk of hypertension diagnosis (hazard ratio [95% confidence interval] 2.19 [1.47–3.26]). Conclusions: Children admitted to the ICU have a high prevalence of hypertension post-discharge and children with AKI have over two times higher risk of hypertension compared to those with no AKI. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
