التفاصيل البيبلوغرافية
| العنوان: |
Membranous nephropathy in Japan: analysis of the Japan Renal Biopsy Registry (J-RBR). |
| المؤلفون: |
Yokoyama, Hitoshi1 h-yoko@kanazawa-med.ac.jp, Taguchi, Takashi2, Sugiyama, Hitoshi3, Sato, Hiroshi4 |
| المصدر: |
Clinical & Experimental Nephrology. Aug2012, Vol. 16 Issue 4, p557-563. 7p. |
| مصطلحات موضوعية: |
*KIDNEY diseases, *RENAL biopsy, *EPIDEMIOLOGY, *NEPHROTIC syndrome, *SYSTEMIC lupus erythematosus, *HYPERTENSION |
| مصطلحات جغرافية: |
JAPAN |
| مستخلص: |
Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults. The J-RBR/J-KDR registry developed by the Japanese Society of Nephrology provides nationwide cohort data for epidemiological studies of MN. MN was present in 36.8% of 1,203 primary nephrotic syndrome patients in Japan. In addition, 633 (77.9%) out of 813 MN patients were referred to as 'idiopathic,' whereas 22.1% were classified as 'secondary' and involved conditions such as systemic lupus erythematosus, drug exposure, infections, cancer, and various collagen diseases. The mean age of the MN patients was 62.2 (2-88) years old, their mean eGFR was 76.7 (7.6-154.6) ml/min/1.73 m, and 63.3% had hypertension at the time of renal biopsy. On the basis of these findings, half of Japanese idiopathic MN patients have risk factors (age >60, male, or lower eGFR) for end-stage renal failure, and 10% belong to the high-risk group (daily proteinuria of over 8.0 g). Further studies with high-grade evidence should resolve the natural history and therapeutic problems of idiopathic MN in elderly Japanese. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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