دورية أكاديمية
Longitudinal study of echocardiography-derived tricuspid regurgitant jet velocity in sickle cell disease
| العنوان: | Longitudinal study of echocardiography-derived tricuspid regurgitant jet velocity in sickle cell disease |
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| المؤلفون: | Desai, Payal C., May, Ryan C., Jones, Susan K., Strayhorn, Dell, Caughey, Melissa, Hinderliter, Alan, Ataga, Kenneth I. |
| المصدر: | British Journal of Haematology, 162(6) |
| سنة النشر: | 2013 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Cancerology, Antineoplastic agent, Cancérologie, Genetic disease, Echocardiography, Sonography, hydroxycarbamide, Antimetabolic, Follow up study, Velocity, Sickle cell anemia, Hemolytic anemia, progression, Hypertension artérielle pulmonaire, Cardiovascular disease, pulmonary hypertension, Hematology, Sickle cell disease, Hemopathy, Hématologie, Respiratory disease, Hemoglobinopathy, tricuspid regurgitant jet velocity |
| الوصف: | Although echocardiography-derived tricuspid regurgitant jet velocity (TRV) is associated with increased mortality in sickle cell disease (SCD), its rate of increase and predictive markers of its progression are unknown. We evaluated 55 subjects (median age: 38 years, range: 20 – 65 years) with at least 2 measurable TRVs, followed for a median of 4.5 years (range: 1.0 – 10.5 years) in a single-centre, prospective study. Thirty-one subjects (56%) showed an increase in TRV, while 24 subjects (44%) showed no change or a decrease in TRV. A linear mixed effects model indicated an overall rate of increase in the TRV of 0.02 m/s per year (p = 0.023). The model showed that treatment with hydroxycarbamide was associated with an initial TRV that was 0.20 m/s lower than no such treatment (p = 0.033), while treatment with angiotensin converting enzyme inhibitors and inhibitors/ angiotensin receptor blockers was associated with an increase in the TRV (p = 0.006). In summary, although some patients have clinically meaningful increases, the overall rate of TRV increase is slow. Treatment with hydroxycarbamide may decrease the progression of TRV. Additional studies are required to determine the optimal frequency of screening echocardiography and the effect of therapeutic interventions on the progression of TRV in SCD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/wbeh-a020Test; https://cdr.lib.unc.edu/downloads/q237j000w?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/q237j000wTest |
| DOI: | 10.17615/wbeh-a020 |
| الإتاحة: | https://doi.org/10.17615/wbeh-a020Test https://cdr.lib.unc.edu/downloads/q237j000w?file=thumbnailTest https://cdr.lib.unc.edu/downloads/q237j000wTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.9F61A0CD |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/wbeh-a020 |
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