التفاصيل البيبلوغرافية
| العنوان: |
Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation. |
| المؤلفون: |
Pagano, Cinzia, Marinozzi, Maura, Baiocchi, Claudio, Beccari, Tommaso, Calarco, Paola, Ceccarini, Maria Rachele, Chielli, Michela, Orabona, Ciriana, Orecchini, Elena, Ortenzi, Roberta, Ricci, Maurizio, Scuota, Stefania, Tiralti, Maria Cristina, Perioli, Luana, Capasso, Raffaele, Di Cesare Mannelli, Lorenzo |
| المصدر: |
Molecules; 1/15/2020, Vol. 25 Issue 2, p318, 1p, 1 Diagram, 3 Charts, 6 Graphs |
| مصطلحات موضوعية: |
SKIN injuries, BIOMEDICAL adhesives, POLYMER films, ONIONS, HYDROGELS, WASTE products, GRANULATION tissue, IN vitro studies |
| مستخلص: |
The onion non-edible outside layers represent a widely available waste material deriving from its processing and consumption. As onion is a vegetable showing many beneficial properties for human health, a study aiming to evaluate the use of extract deriving from the non-edible outside layers was planned. An eco-friendly extraction method was optimized using a hydroalcoholic solution as solvent. The obtained extract was deeply characterized by in vitro methods and then formulated in autoadhesive, biocompatible and pain-free hydrogel polymeric films. The extract, very soluble in water, showed antioxidant, radical scavenging, antibacterial and anti-inflammatory activities, suggesting a potential dermal application for wounds treatment. In vitro studies showed a sustained release of the extract from the hydrogel polymeric film suitable to reach concentrations necessary for both antibacterial and anti-inflammatory activities. Test performed on human keratinocytes showed that the formulation is safe suggesting that the projected formulation could be a valuable tool for wound treatment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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