المؤلفون: Funnell, Jonathan P., Craven, Claudia L., Thompson, Simon D., D’Antona, Linda, Chari, Aswin, Thorne, Lewis, Watkins, Laurence D., Toma, Ahmed K.

المصدر: Acta Neurochirurgica; Oct2018, Vol. 160 Issue 10, p2025-2029, 5p, 1 Chart, 2 Graphs

مصطلحات موضوعية: INTRACRANIAL hypertension, PULSATILE flow, CEREBROSPINAL fluid, TINNITUS, MAGNETIC resonance imaging

مستخلص: Introduction: Tinnitus is a symptom commonly associated with idiopathic intracranial hypertension (IIH) that can have a profound effect on quality of life. We aim to determine tinnitus symptom response after dural venous sinus stenting (DVSS) or CSF diversion with a shunt, in patients with both pulsatile (PT) and non-pulsatile tinnitus (NPT).Methods: Single-centre cohort of IIH patients (2006-2016) who underwent 24-h ICP monitoring (ICPM). An un-paired t test compared ICP and pulse amplitude (PA) values in IIH patients with PT vs. NPT.Results: We identified 59 patients with IIH (56 F:3 M), mean age 32.5 ± 9.49 years, 14 of whom suffered from tinnitus. Of these 14, seven reported PT and seven reported NPT. Patients with tinnitus had a mean 24-h ICP and PA of 9.09 ± 5.25 mmHg and 6.05 ± 1.07 mmHg respectively. All 7 patients with PT showed symptom improvement or resolution after DVSS (n = 4), secondary DVSS (n = 2) or shunting (n = 1). In contrast, of the 7 with NPT, only 1 improved post intervention (DVSS), despite 2 patients having shunts and 5 having DVSS.Conclusions: NPT and PT were equally as common in our group of IIH patients. DVSS appears to be an effective management option for IIH patients with a clear history of pulsatile tinnitus. However, non-pulsatile tinnitus was more persistent and did not respond well to either DVSS or CSF diversion. [ABSTRACT FROM AUTHOR]

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المؤلفون: Thompson, Simon D.

المصدر: British Journal of Neuroscience Nursing; Apr/May2017, Vol. 13 Issue 2, p76-81, 6p, 6 Diagrams

مستخلص: Hydrocephalus is one of the most common neurosurgical conditions or complications. This is the second paper in the hydrocephalus series. Here, idiopathic normal pressure hydrocephalus (iNPH) will be discussed, focusing on the presenting symptoms, treatment options, risks, effects on care needs and gaps in the current literature. [ABSTRACT FROM AUTHOR]

: Copyright of British Journal of Neuroscience Nursing is the property of Mark Allen Holdings Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Thompson, Simon D¹ simon.thompson3@nhs.net, Richens, Yana²

المصدر: British Journal of Midwifery. Mar2017, Vol. 25 Issue 3, p156-159. 4p. 6 Color Photographs.

مصطلحات موضوعية: *MIDWIFERY, *CEREBROSPINAL fluid, *CEREBROSPINAL fluid shunts, *HIGH-risk pregnancy, *HYDROCEPHALUS, *PREGNANCY complications, *PREGNANT women, *PRENATAL care

مستخلص: Advances in medicine mean there are more women with complex medical histories giving birth. This may include women with conditions such as hydrocephalus requiring a cerebrospinal fluid shunt. Midwives should understand the principles of care for such women and work with the multidisciplinary team to provide indiviulaised care throughout the pregnancy and intrapartum period. [ABSTRACT FROM AUTHOR]

المؤلفون: Thompson, Simon D.

المصدر: British Journal of Neuroscience Nursing; Fev/Mar2017, Vol. 13 Issue 1, p36-40, 5p, 1 Chart

مستخلص: Hydrocephalus is one of the most common neurosurgical conditions or complications. Common treatment options have not changed in decades. However, recent technological advances and improvement in infection rates and outcomes have caused clinicians to rethink attitudes and understanding towards hydrocephalus and patient management. This article is the introduction to a series in which different types of hydrocephalus will be discussed, including various treatment options and recent technological advances that are improving outcomes and diagnostic techniques. [ABSTRACT FROM AUTHOR]

: Copyright of British Journal of Neuroscience Nursing is the property of Mark Allen Holdings Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Craven, Claudia Louise, Chapman, Miles D., D'Antona, Linda, Thompson, Simon D., Lakdawala, Neghat, Zetterberg, Henrik, Watkins, Laurence D., Toma, Ahmed K.

المصدر: Journal of Clinical Pathology; Jan2019, Vol. 72 Issue 1, p91-92, 2p

مصطلحات موضوعية: CEREBROSPINAL fluid, TAU proteins, AMYLOID beta-protein, BIOMARKERS, AMYLOID plaque, HYDROCEPHALUS, ALZHEIMER'S disease diagnosis, NEURODEGENERATION

المؤلفون: Craven, Claudia L.¹ claudia.craven@gmail.com, Baudracco, Irene¹, Thompson, Simon D.¹, Thorne, Lewis¹, Watkins, Laurence D.¹, Toma, Ahmed K.¹

المصدر: World Neurosurgery. Feb2018, Vol. 110, pe514-e519. 1p.

مصطلحات موضوعية: *HYDROCEPHALUS, *TRAUMATIC tentorial herniation, *BRAIN injuries, *BRAIN diseases, *CEREBRAL ventricles, *THERAPEUTICS

مستخلص: Background Complex hydrocephalus affecting lateral and fourth ventricles separately is occasionally managed with cerebrospinal fluid diversion via supratentorial and infratentorial ventricular catheters. The optimal configuration to reduce complications is currently unknown in adults. We describe a consistently similar clinical presentation of patients with complex hydrocephalus and a fourth ventricle separately drained by infratentorial shunt insertion. Methods This was a retrospective single-center case series. Medical notes were reviewed for clinical presentation, brain imaging, and neurophysiologic tests results. All patients underwent intracranial pressure monitoring (ICPM). Outcomes were determined by ventricular appearance on brain imaging computed tomography and symptomatic improvements postoperatively. Results Five adult patients referred to the hydrocephalus service had separate infratentorial and supratentorial shunt systems. A common clinical presentation was observed, including lower motor neuron facial palsy (confirmed with electrophysiology), ophthalmoplegia, dysarthria, impaired gait headache, and nausea. We refer to this as transtentorial distortion syndrome. Twenty-four-hour ICPM demonstrated clear low pressures. All patients underwent shunt revision connecting the transtentorial shunts via a Y-connector and the addition of a distal valve. All subjects had improved ventricular appearance on computed tomography scans post revision, and normalization of ICPM was observed. In the follow-up period of 6 months, no patient required further shunt revision. Conclusion To prevent transtentorial distortion syndrome, supratentorial and infratentorial shunt constructs in adults with encysted fourth ventricles should be similar to the shunt systems widely known in the pediatric population with Dandy-Walker syndrome (i.e., joint output to a single valve distal to the connection of the 2 proximal drainage catheters). [ABSTRACT FROM AUTHOR]