دورية أكاديمية
胎儿轻度侧脑室增宽的产前诊断及预后 ; Prenatal diagnosis and prognosis of fetuses with mild ventriculomegaly
| العنوان: | 胎儿轻度侧脑室增宽的产前诊断及预后 ; Prenatal diagnosis and prognosis of fetuses with mild ventriculomegaly |
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| المؤلفون: | 李奎, 王爽, 陈静, 孙瑜, 杨慧霞 |
| المساهمون: | 100034,北京大学第一医院妇产科, 10003北京大学第一医院妇产科, 07560河北省张家口市涿鹿县医院妇产科 |
| المصدر: | 万方 ; CSCD ; http://d.g.wanfangdata.com.cn/Periodical_zhwcyxzz201606006.aspxTest |
| بيانات النشر: | 中华围产医学杂志 |
| سنة النشر: | 2016 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | 脑积水, 产前诊断, 预后, Hydrocephalus, Prenatal diagnosis, Prognosis |
| الوصف: | 目的 探讨胎儿轻度侧脑室增宽的产前诊断及预后状况,为临床咨询及处理提供依据. 方法 回顾性分析2013年1月1日至201 5年5月31日于北京大学第一医院妇产科超声筛查提示胎儿侧脑室增宽,且经超声会诊确诊为胎儿侧脑室轻度增宽并成功进行结局追踪的病例共116例.统计胎儿头颅MRi检查及有创产前诊断的情况,并根据Gesell发育量表电话随访新生儿出生后生长发育情况.对数据资料采用描述性统计分析. 结果 88例孤立性轻度侧脑室增宽的病例中,48例(54.5％)接受了染色体检查或筛查,仅有1例染色体异常,为不平衡易位;随访到83例顺利分娩的孕妇,仅有l例婴幼儿(1.2％)出现生长发育迟缓、智力及运动发育均落后.28例非孤立性轻度侧脑室增宽病例中,17例(60.7％)接受染色体检查或筛查,均未见异常;在顺利分娩的1 8例中,1例染色体正常,但胎儿头颅MRi提示大脑发育不良,分娩后证实诊断,且婴儿生长发育迟缓;其余17例未发现异常. 结论 孤立性轻度侧脑室增宽者染色体异常概率较低.若孕期情况稳定,其新生儿预后良好.是否应该对于所有轻度侧脑室增宽的患者进行有创产前诊断,有待商榷. ; Objective To investigate the prenatal diagnosis and prognosis of fetuses with mild ventriculomegaly in order to provide evidence for clinical consultation and treatment.Methods The data of 116 mothers with fetal ventriculomegaly who received prenatal care in Peking University First Hospital between January 1,2013 and May 31,2015 were retrospectively analyzed.All cases of fetal ventriculomegaly were found by ultrasound screening,and were subsequently diagnosed by ultrasound consultation as mild ventriculomegaly.The results of fetal cerebral MRI and invasive prenatal diagnosis were analyzed and the growth and development of babies were followed up by telephone using the Gesell developmental scale.All data was analyzed by descriptive statistics.Results Of the 88 cases of solitary ventriculomegaly,48 (54.5％) received karyotype analysis or screening,and only one case was found to be abnormal,which was an unbalanced translocation.Of the 83 mothers with normal delivery,only one infant (1.2％) showed retardation of intelligence and motor development.Of the 28 cases of non-solitary ventriculomegaly,17 (60.7％) received karyotype analysis or screening,and no abnormalities were found.Of the 18 mothers with normal delivery,only one infant showed retardation of growth and development,and was found to have brain hypoplasia before delivery by MRI with normal karyotype.Conclusions The rate of abnormal karyotype in mild vetriculomegaly is very low in this study.The width of the lateral ventricles is stable during pregnancy and the prognosis of ... |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | Chinese |
| تدمد: | 1007-9408 |
| العلاقة: | 中华围产医学杂志.2016,19(6),418-421.; 1444235; http://hdl.handle.net/20.500.11897/493880Test |
| DOI: | 10.3760/cma.j.issn.1007-9408.2016.06.005 |
| الإتاحة: | https://doi.org/20.500.11897/493880Test https://doi.org/10.3760/cma.j.issn.1007-9408.2016.06.005Test https://hdl.handle.net/20.500.11897/493880Test |
| رقم الانضمام: | edsbas.351E56C4 |
| قاعدة البيانات: | BASE |
| تدمد: | 10079408 |
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| DOI: | 10.3760/cma.j.issn.1007-9408.2016.06.005 |