التفاصيل البيبلوغرافية
| العنوان: |
Genetically determined telomere length and multiple myeloma risk and outcome |
| المؤلفون: |
Giaccherini, Matteo, Macauda, Angelica, Orciuolo, Enrico, Rymko, Marcin, Gruenpeter, Karolina, Dumontet, Charles, Raźny, Malgorzata, Moreno, Victor, Buda, Gabriele, Beider, Katia, Varkonyi, Judit, Avet-Loiseau, Hervé, Martinez-Lopez, Joaquin, Marques, Herlander, Watek, Marzena, Sarasquete, Maria Eugenia, Andersen, Vibeke, Karlin, Lionel, Suska, Anna, Kruszewski, Marcin, Abildgaard, Niels, Dudziński, Marek, Butrym, Aleksandra, Nagler, Arnold, Vangsted, Annette Juul, Kadar, Katalin, Tomczak, Waldemar, Jamroziak, Krzysztof, Jacobsen, Svend Erik Hove, Ebbesen, Lene Hyldahl, Taszner, Michał, Mazur, Grzegorz, Lesueur, Fabienne, Pelosini, Matteo, Garcia-Sanz, Ramon, Jurczyszyn, Artur, Demangel, Delphine, Reis, Rui Manuel, Iskierka-Jażdżewska, Elżbieta, Markiewicz, Miroslaw, Gemignani, Federica, Subocz, Edyta, Zawirska, Daria, Druzd-Sitek, Agnieszka, Stępień, Anna, Alonso, M. Henar, SAINZ, JUAN, Canzian, Federico, Campa, Daniele |
| المصدر: |
http://lobid.org/resources/99370674244606441Test#!, 11(4):74. |
| سنة النشر: |
2021 |
| المجموعة: |
Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: |
Genetic Predisposition to Disease [MeSH], Female [MeSH], Aged [MeSH], Polymorphism, Single Nucleotide [MeSH], Adult [MeSH], Humans [MeSH], Prospective Studies [MeSH], Telomere Homeostasis [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Multiple Myeloma/genetics [MeSH], Risk factors, Genome-Wide Association Study [MeSH], Article, Male [MeSH], Prognosis [MeSH], Myeloma, Telomere/genetics [MeSH], Multiple Myeloma/diagnosis [MeSH] |
| الوصف: |
Telomeres are involved in processes like cellular growth, chromosomal stability, and proper segregation to daughter cells. Telomere length measured in leukocytes (LTL) has been investigated in different cancer types, including multiple myeloma (MM). However, LTL measurement is prone to heterogeneity due to sample handling and study design (retrospective vs. prospective). LTL is genetically determined; genome-wide association studies identified 11 SNPs that, combined in a score, can be used as a genetic instrument to measure LTL and evaluate its association with MM risk. This approach has been already successfully attempted in various cancer types but never in MM. We tested the 'teloscore' in 2407 MM patients and 1741 controls from the International Multiple Myeloma rESEarch (IMMeNSE) consortium. We observed an increased risk for longer genetically determined telomere length (gdTL) (OR = 1.69; 95% CI 1.36-2.11; P = 2.97 × 10 |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://repository.publisso.de/resource/frl:6443590Test; https://doi.org/10.1038/s41408-021-00462-yTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046773Test/ |
| DOI: |
10.1038/s41408-021-00462-y |
| الإتاحة: |
https://doi.org/10.1038/s41408-021-00462-yTest
https://repository.publisso.de/resource/frl:6443590Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046773Test/ |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.8BFD956D |
| قاعدة البيانات: |
BASE |
