نتائج البحث - "integrin-linked kinase"

1

دورية أكاديمية

Chronic kidney disease induced by an adenine rich diet upregulates integrin linked kinase (ILK) and its depletion prevents the disease progression.

المؤلفون: de Frutos, Sergio, Luengo, Alicia, García-Jérez, Andrea, Hatem-Vaquero, Marco, Griera, Mercedes, O'Valle, Francisco, Rodríguez-Puyol, Manuel, Rodríguez-Puyol, Diego, Calleros, Laura

العلاقة: http://hdl.handle.net/10668/13525Test; https://doi.org/10.1016/j.bbadis.2019.01.024Test

الإتاحة: https://doi.org/10.1016/j.bbadis.2019.01.024Test
http://hdl.handle.net/10668/13525Test

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النص الكامل

2

Insight into the mechanism of molecular recognition between human Integrin-Linked Kinase and Cpd22 and its implication at atomic level

المؤلفون: Javier García-Marín, Diego Rodríguez-Puyol, Juan J. Vaquero

المساهمون: Universidad de Alcalá. Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá. Departamento de Química Orgánica y Química Inorgánica, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Comunidad de Madrid, García-Marín, Javier, Rodríguez-Puyol, Diego, Vaquero, Juan J., García-Marín, Javier [0002-5883-4783], Rodríguez-Puyol, Diego [0000-0002-9125-9311], Vaquero, Juan J. [0000-0002-3820-9673]

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
e_Buah Biblioteca Digital Universidad de Alcalá

مصطلحات موضوعية: PELE, ILK, Cpd22, Pseudokinase, Química, Molecular dynamics, Protein Serine-Threonine Kinases, Computer Science Applications, Chemistry, Adenosine Triphosphate, Drug Discovery, Humans, Pyrazoles, Physical and Theoretical Chemistry, ILK, Integrin-linked kinase, Cpd22, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35353f8ffb6fa834dc84aa43e5e426e6Test
https://pubmed.ncbi.nlm.nih.gov/35869378Test

3

The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1

المؤلفون: Peter W. Krenn, Helena Block, Giulia Germena, Barbara Heitplatz, Andreas Margraf, Hermann Haller, Chang Liu, Nadine Ludwig, Dietmar Vestweber, Jan Rossaint, Wiebke Gottschlich, Marika Meyer zu Brickwedde, Barbara Prystaj, Alexander Zarbock, Sina Mersmann, Katharina Thomas, Markus Moser, Hannes C.A. Drexler

المصدر: Blood

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d058140d099e1c7e123926274e9778Test
https://doi.org/10.1182/blood.2020004948Test

4

Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors

المؤلفون: Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton

المصدر: Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373Test
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373Test

مصطلحات موضوعية: Cancer Research, Breast Neoplasms, Aniline Compounds/pharmacology, Kaplan-Meier Estimate, bosutinib, Protein Serine-Threonine Kinases, Breast Neoplasms/enzymology, Cell Proliferation/drug effects, Gene Knockout Techniques, Breast cancer, Cell Line, Tumor, Signal Transduction/drug effects, Nitriles, Animals, Humans, Integrin-linked kinase, Protein Kinase Inhibitors, Cell Proliferation, Mice, Knockout, Quinolines/pharmacology, Aniline Compounds, Gene Expression Profiling, Xenograft Model Antitumor Assays, synthetic lethality, Gene Expression Regulation, Neoplastic, src-Family Kinases, src-Family Kinases/antagonists & inhibitors, Xenograft Model Antitumor Assays/methods, Oncology, Protein Kinase Inhibitors/pharmacology, Nitriles/pharmacology, Quinolines, MCF-7 Cells, Female, Protein Serine-Threonine Kinases/genetics, Gene Expression Profiling/methods, Signal Transduction, SRC

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6Test
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdfTest

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Serum deprivation‐response protein regulates aldehyde dehydrogenase 1 through integrin‐linked kinase signaling in endometrioid carcinoma cells

المؤلفون: Masako Kurashige, Jun-ichiro Ikeda, Satoshi Nojima, Eiichi Morii, Daisuke Okuzaki, Yumiko Hori, Naoki Wada, Shinichiro Tahara, Kenji Ohshima, Yuichi Motoyama

المصدر: Cancer Science

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Cancer Research, Epithelial-Mesenchymal Transition, Aldehyde dehydrogenase, Biology, integrin‐linked kinase, Protein Serine-Threonine Kinases, Aldehyde Dehydrogenase 1 Family, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, Pathology, serum deprivation‐response protein, Humans, Integrin-linked kinase, Neoplasm Invasiveness, aldehyde dehydrogenase 1, Cell Proliferation, Kinase, microcystic, elongated and fragmented, Retinal Dehydrogenase, General Medicine, Original Articles, Aldehyde Dehydrogenase, Phosphate-Binding Proteins, Molecular biology, Endometrial Neoplasms, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, Tumor progression, 030220 oncology & carcinogenesis, biology.protein, Original Article, Female, Stem cell, SDPR, Carrier Proteins, Carcinoma, Endometrioid, Cavin, endometrioid carcinoma, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08bc10b6b0cd70b16a466deaeabf65fTest
http://europepmc.org/articles/PMC6500992Test

6

دورية أكاديمية

Loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling

المساهمون: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Moleküler Biyoloji ve Genetik Bölümü., orcid:0000-0002-1459-5485, Uz, Elif, 13807893000

مصطلحات موضوعية: Genetics & heredity, Integrin-linked kinase, Craniofacial region, Sequencing data, Cell-migration, Angiogenesis, Mechanism, Complex, Lesions, Growth, Bone, Adaptor proteins, signal transducing, Adult, Alleles, Animals, Bone and bones, Cell movement, Cytoskeletal proteins, Evolution, molecular, Female, Homozygote, Humans, Male, Mutation, Phenotype, Phylogeny, Rac GTP-binding proteins, Rac1 GTP-binding protein

وصف الملف: application/pdf

العلاقة: 108S420; K030-T439; 2011K120020; Makale - Uluslararası Hakemli Dergi; American Journal of Human Genetics; Yurt içi; Yurt dışı; Sanayi; Çetinkaya, A. vd. (2016). "Loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling". American Journal of Human Genetics, 99(2), 299-317.; https://doi.org/10.1016/j.ajhg.2016.06.008Test; https://www.sciencedirect.com/science/article/pii/S0002929716302105Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974086Test/; http://hdl.handle.net/11452/29550Test; 000381617200004; 2-s2.0-84979752469; 299; 317; 99

الإتاحة: https://doi.org/10.1016/j.ajhg.2016.06.008Test
http://hdl.handle.net/11452/29550Test
https://www.sciencedirect.com/science/article/pii/S0002929716302105Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974086Test/

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النص الكامل