نتائج البحث - "Veli-Matti Leppänen"

1

Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem–like Cells

المؤلفون: Diego Balboa, Zoltán Wiener, Kari Alitalo, Pauliina Kallio, Veli-Matti Leppänen, Jenny Högström, Marianne Lähde, Sarika Heino

المصدر: Cancer Research. 78:5820-5832

مصطلحات موضوعية: Adenoma, Male, 0301 basic medicine, Cancer Research, Notch signaling pathway, Mice, Transgenic, Biology, Mice, 03 medical and health sciences, Organ Culture Techniques, Cell Line, Tumor, medicine, Animals, Humans, Cell Lineage, Transcription factor, Crosses, Genetic, Cell Proliferation, Oligonucleotide Array Sequence Analysis, Homeodomain Proteins, Receptors, Notch, Sequence Analysis, RNA, Tumor Suppressor Proteins, HEK 293 cells, Genes, Homeobox, LGR5, Wnt signaling pathway, Cancer, medicine.disease, Nucleosomes, Intestines, HEK293 Cells, 030104 developmental biology, Oncology, Tumor progression, Neoplastic Stem Cells, Cancer research, Female, Stem cell, Colorectal Neoplasms

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10640588a0748557a0c5e1144cf7b12Test
https://doi.org/10.1158/0008-5472.can-18-0451Test

2

Investigation on the role of biallelic variants in VEGF-C found in a patient affected by Milroy-like lymphedema

المؤلفون: Sylvain Mukenge, Matteo Bertelli, Andrea Brendolan, Elisa Lenti, Michael Jeltsch, Luca Aldrighetti, Sawan Kumar Jha, Daniela Negrini, Elena Manara, Veli-Matti Leppänen, Marco Catena

المساهمون: CAN-PRO - Translational Cancer Medicine Program, Michael Jeltsch / Principal Investigator, Research Programs Unit, University of Helsinki, Kari Alitalo / Principal Investigator, Helsinki One Health (HOH), INDIVIDRUG - Individualized Drug Therapy, Mukenge, S., Jha, S. K., Catena, M., Manara, E., Leppanen, V. -M., Lenti, E., Negrini, D., Bertelli, M., Brendolan, A., Jeltsch, M., Aldrighetti, L.

المصدر: Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020)

مصطلحات موضوعية: 0301 basic medicine, Proband, Male, lymphatic system, Milroy disease, mutation, primary lymphedema, VEGF-C, VEGF‐C, Vascular Endothelial Growth Factor C, Disease, 030105 genetics & heredity, medicine.disease_cause, GROWTH FACTOR-C, Lymphedema, Child, Genetics (clinical), Genetics, Mutation, medicine.diagnostic_test, 1184 Genetics, developmental biology, physiology, Middle Aged, Pedigree, Phenotype, Original Article, Female, LYMPHANGIOGENESIS, Adult, lcsh:QH426-470, Mutation, Missense, MECHANISMS, 03 medical and health sciences, medicine, Humans, Primary lymphedema, Molecular Biology, Alleles, Genetic testing, business.industry, Original Articles, medicine.disease, FLT4, lcsh:Genetics, 030104 developmental biology, Etiology, 3111 Biomedicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8973a6bd940de425fc8833f07caa69b2Test
http://hdl.handle.net/10138/320997Test

3

High baseline Tie1 level predicts poor survival in metastatic breast cancer

المؤلفون: Emilia A. Korhonen, Mari Hämäläinen, Kari Alitalo, Leena Tiainen, Pirkko-Liisa Kellokumpu-Lehtinen, Arja Jukkola, Peeter Karihtala, Tiina Luukkaala, Minna Tanner, Pia Vihinen, Outi Lahdenperä, Sonja Aho, Veli-Matti Leppänen, Eeva Moilanen

المساهمون: CAN-PRO - Translational Cancer Medicine Program, Research Programs Unit, University of Helsinki, University Management, Kari Alitalo / Principal Investigator, HUSLAB, Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, Tampere University

المصدر: BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: BIOMARKER, 0301 basic medicine, Oncology, Cancer Research, SERUM ANGIOPOIETIN-2, Angiogenesis, PROGRESSION, RECEPTOR TYROSINE KINASE, Docetaxel, INHIBITS TUMOR-GROWTH, Prognostic marker, 0302 clinical medicine, Surgical oncology, Antineoplastic Combined Chemotherapy Protocols, 1ST-LINE BEVACIZUMAB, Breast, Prospective Studies, Combination chemotherapy, Receptor, TIE-1, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, Metastatic breast cancer, Progression-Free Survival, 3. Good health, Lymphangiogenesis, Bevacizumab, Tie1, 030220 oncology & carcinogenesis, Female, medicine.symptom, Research Article, Adult, medicine.medical_specialty, 3122 Cancers, Breast Neoplasms, Inflammation, lcsh:RC254-282, Drug Administration Schedule, Angiopoietin-2, Angiopoietin, 03 medical and health sciences, Breast cancer, Syöpätaudit - Cancers, Internal medicine, Biomarkers, Tumor, Genetics, medicine, Humans, ANTAGONIST, Aged, business.industry, medicine.disease, Survival Analysis, 030104 developmental biology, ANGIOPOIETIN-2 EXPRESSION, PLUS WEEKLY PACLITAXEL, 3111 Biomedicine, business

وصف الملف: fulltext; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373079abef2a28f9fd06335bd6a33b59Test
https://doi.org/10.1186/s12885-019-5959-8Test

4

Characterization of

المصدر: Science translational medicine. 12(560)

مصطلحات موضوعية: Angiopoietin-2, Pregnancy, Mutation, Angiopoietin-1, Endothelial Cells, Humans, Female, Lymphedema, Lymphangiogenesis, Receptor, TIE-2, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::a1aabc1ba7f8027ba2c4b96fc01f3534Test
https://pubmed.ncbi.nlm.nih.gov/32908006Test

5

Vascular endothelial growth factor signaling in development and disease

المؤلفون: Sinem Karaman, Kari Alitalo, Veli-Matti Leppänen

المساهمون: Translational Cancer Biology (TCB) Research Programme, Research Programs Unit, Kari Alitalo / Principal Investigator

المصدر: Development

مصطلحات موضوعية: Vascular Endothelial Growth Factor A, 0301 basic medicine, Receptor tyrosine kinase, VEGF receptors, VEGF-C, PRIMARY LYMPHEDEMA, Disease, PERMEABILITY FACTOR, TUMOR ANGIOGENESIS, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Lymphatic vessel, medicine, Animals, Humans, Molecular Biology, IN-VIVO, Lymphatic Vessels, biology, VEGF, PHOSPHORYLATION SITES, Vascular endothelial growth factor, Receptors, Vascular Endothelial Growth Factor, 030104 developmental biology, Lymphatic system, medicine.anatomical_structure, chemistry, HIGH-AFFINITY BINDING, biology.protein, Cancer research, Blood Vessels, Vessels, 3111 Biomedicine, Tyrosine kinase, INDUCED ANGIOGENESIS, Signal Transduction, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a72629e9526611dce0599976c717186Test
https://doi.org/10.1242/dev.151019Test

6

Genetic Variants of

المؤلفون: Daniel J, Crona, Andrew D, Skol, Veli-Matti, Leppänen, Dylan M, Glubb, Amy S, Etheridge, Eleanor, Hilliard, Carol E, Peña, Yuri K, Peterson, Nancy, Klauber-DeMore, Kari K, Alitalo, Federico, Innocenti

المصدر: Cancer research. 79(1)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::3d3d7b8db376498009038652d349b6b2Test
https://pubmed.ncbi.nlm.nih.gov/30385613Test

7

SnapShot: Angiopoietins and Their Functions

المؤلفون: Pipsa Saharinen, Veli-Matti Leppänen, Kari Alitalo

المصدر: Cell. 171(3)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0df4e967cf0ba5934c6a0516ac9fbd1Test
https://pubmed.ncbi.nlm.nih.gov/29053972Test

8

Functional Dissection of the CCBE1 Protein

المؤلفون: Stefan Schulte-Merker, Michael Jeltsch, Veli-Matti Leppänen, Yvonne Padberg, Kari Alitalo, Josi Peterson-Maduro, M. Guy Roukens, Frank L. Bos, Dörte Schulte

المصدر: Circulation Research, 116(10), 1660. Lippincott Williams and Wilkins

مصطلحات موضوعية: Physiology, Vascular Endothelial Growth Factor C, Mutant, Regulator, Craniofacial Abnormalities, Mice, 0302 clinical medicine, vascular, Gene Knock-In Techniques, Lymphedema, Lymphangiogenesis, Non-U.S. Gov't, Zebrafish, Medicine(all), 0303 health sciences, biology, Research Support, Non-U.S. Gov't, Gene Expression Regulation, Developmental, Cell biology, Phenotype, Vascular endothelial growth factor C, CCBE1 protein, 030220 oncology & carcinogenesis, Collagen, Genital Diseases, Male, Cardiology and Cardiovascular Medicine, Protein Binding, Signal Transduction, Endothelium, vascular, Genotype, Protein domain, Gestational Age, Mice, Transgenic, Research Support, Transfection, 03 medical and health sciences, Hennekam lymphangiectasia-lymphedema syndrome, In vivo, Journal Article, Animals, Humans, Protein Interaction Domains and Motifs, Endothelium, Lymphatic Vessels, 030304 developmental biology, Phenocopy, Binding Sites, Epidermal Growth Factor, Tumor Suppressor Proteins, Calcium-Binding Proteins, Endothelial Cells, Zebrafish Proteins, biology.organism_classification, HEK293 Cells, Mutation, Immunology, biology.protein, Vascular endothelial growth factor, Protein A, Lymphangiectasis, Intestinal

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfaa06a9ab3adc625b01b56e0fd6642Test
https://doi.org/10.1161/circresaha.116.304949Test

9

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

المؤلفون: Terhi Karpanen, Michael Jeltsch, Pascal Brouillard, Sawan Kumar Jha, Miikka Vikkula, Kari Alitalo, Veli-Matti Leppänen, Khushbu Rauniyar

المساهمون: UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/GEHU - Génétique, Research Programs Unit, Michael Jeltsch / Principal Investigator, Translational Cancer Biology (TCB) Research Programme, Kari Alitalo / Principal Investigator, University of Helsinki, Clinicum

المصدر: Scientific Reports
Scientific reports, Vol. 7, no. 1, p. 4916 [1-13] (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: 0301 basic medicine, Science, medicine.medical_treatment, education, Protein domain, Vascular Endothelial Growth Factor C, Mice, Transgenic, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Protein Domains, Chlorocebus aethiops, Disintegrin, medicine, Animals, Humans, Amino Acid Sequence, Lymphedema, Lymphangiogenesis, Protein Precursors, Lymphatic Vessels, Thrombospondin, Metalloproteinase, Multidisciplinary, biology, Growth factor, Tumor Suppressor Proteins, Calcium-Binding Proteins, Endothelial Cells, Vascular Endothelial Growth Factor Receptor-3, 030104 developmental biology, HEK293 Cells, Vascular endothelial growth factor C, Amino Acid Substitution, Gene Expression Regulation, 030220 oncology & carcinogenesis, COS Cells, Proteolysis, Cancer research, biology.protein, NIH 3T3 Cells, Medicine, 3111 Biomedicine, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a6c803b8c7228b4cd5510168cdcbbcTest
http://europepmc.org/articles/PMC5501841Test

10

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

المؤلفون: Veli-Matti Leppänen, Kurt Ballmer-Hofer, Saša Bjelić, Thomas Schleier, Kari Alitalo, Maurice S. Brozzo, Fritz K. Winkler, Kaisa Kisko

المصدر: Blood

مصطلحات موضوعية: Models, Molecular, Immunology, Allosteric regulation, Plasma protein binding, Spodoptera, Ligands, Biochemistry, Pichia, Receptor tyrosine kinase, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Allosteric Regulation, Animals, Humans, Protein Structure, Quaternary, Receptor, Cells, Cultured, 030304 developmental biology, 0303 health sciences, Vascular Endothelial Growth Factor Receptor-1, biology, Chemistry, Kinase, Isothermal titration calorimetry, Cell Biology, Hematology, Vascular Endothelial Growth Factor Receptor-3, Vascular Endothelial Growth Factor Receptor-2, 030220 oncology & carcinogenesis, biology.protein, Biophysics, Thermodynamics, Protein Multimerization, Function (biology), Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0327bd36dbce1e3904b2f29a310c6c5cTest

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