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المؤلفون: Yvan Varisco, Anne Hamel, Nampally Sreenivasachary, Wolfgang Froestl, Valérie Giriens, Heiko Kroth, Pascal Benderitter, Andreas Muhs, Andrea Pfeifer, Paolo Paganetti
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3330-3335
مصطلحات موضوعية: 0301 basic medicine, Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Protein Aggregates, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, β amyloid, Drug Discovery, Pyridine, Humans, Structure–activity relationship, Moiety, Molecular Biology, Amyloid beta-Peptides, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Hydrogen bond, Organic Chemistry, 0104 chemical sciences, 030104 developmental biology, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9312584d8d514d20c50ae6f46c639fTest
https://doi.org/10.1016/j.bmcl.2016.05.040Test -
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المؤلفون: Nampally Sreenivasachary, Paolo Paganetti, Valérie Giriens, Luitgard Nagel-Steger, Markus Zweckstetter, Oskar Adolfsson, Andreas Muhs, Heiko Kroth, Maria Pihlgren, Andrea Pfeifer, Thomas Schrader, Sophie Lohmann, Yvan Varisco, Asad Jan, Nasrollah Rezaei-Ghaleh, María Pilar López-Deber, Annalisa Ansaloni, Hilal A. Lashuel, Wolfgang Froestl, Dieter Willbold
المصدر: Journal of Biological Chemistry
The journal of biological chemistry 287(41), 34786-34800 (2012). doi:10.1074/jbc.M112.357665
Kroth, H, Ansaloni, A, Varisco, Y, Jan, A, Sreenivasachary, N, Rezaei-Ghaleh, N, Giriens, V, Lohmann, S, López-Deber, M P, Adolfsson, O, Pihlgren, M, Paganetti, P, Froestl, W, Nagel-Steger, L, Willbold, D, Schrader, T, Zweckstetter, M, Pfeifer, A, Lashuel, H A & Muhs, A 2012, ' Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation ', The Journal of biological chemistry, vol. 287, no. 41, pp. 34786-800 . https://doi.org/10.1074/jbc.M112.357665Testمصطلحات موضوعية: 3-aminopyrazole, antagonists & inhibitors [Amyloid beta-Peptides], antagonists & inhibitors [Cytotoxins], antagonists & inhibitors [Peptide Fragments], Chemie, chemistry [Cytotoxins], Protein aggregation, Biochemistry, Protein Structure, Secondary, Hydrophobic effect, Structure-Activity Relationship, Protein structure, Cell Line, Tumor, mental disorders, Journal Article, Humans, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Cytotoxins, Chemistry, Research Support, Non-U.S. Gov't, In vitro toxicology, Molecular Bases of Disease, Hydrogen Bonding, Cell Biology, amyloid beta-protein (1-42), Small molecule, Peptide Fragments, Amino acid, chemistry [Peptide Fragments], ddc:540, chemistry [Pyrazoles], Pyrazoles, chemistry [Amyloid beta-Peptides], Hydrophobic and Hydrophilic Interactions, Linker
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f1d6b8bb6eb1e9cd8d68fd89416ac0Test
https://hdl.handle.net/11858/00-001M-0000-000E-7305-311858/00-001M-0000-000E-7304-511858/00-001M-0000-000E-7300-DTest -
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المؤلفون: Maria Pihlgren, Andrea Pfeifer, Dorin Mlaki Ndao, Claude Nicolau, Marc Baldus, Deepak Nand, Rime Madani, David T. Hickman, María Pilar López-Deber, Luitgard Nagel-Steger, Andreas Muhs, Valérie Giriens, Annie St-Pierre, Dieter Willbold, Detlev Riesner, Alberto B. Silva, Hristina Karastaneva
المصدر: Journal of Biological Chemistry, 286(16), 13966. American Society for Biochemistry and Molecular Biology Inc.
مصطلحات موضوعية: Amyloid, Protein Folding, Magnetic Resonance Spectroscopy, Protein Conformation, Lipid-anchored protein, Peptide, Biology, Biochemistry, Epitope, Protein Structure, Secondary, chemistry.chemical_compound, Mice, Protein structure, Alzheimer Disease, Animals, Humans, Benzothiazoles, Neurodegeneration, Proteostasis Deficiencies, Molecular Biology, chemistry.chemical_classification, Vaccines, Circular Dichroism, Lipopeptide, Peptide Conformation, Cell Biology, Small molecule, Protein Structure, Tertiary, Mice, Inbred C57BL, Protein Misfolding, Thiazoles, chemistry, Immunoglobulin G, Liposomes, Protein Structure and Folding, Protein folding, Female, Peptides
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a337f57da46a893e698aab99ff2d80ecTest
https://pubmed.ncbi.nlm.nih.gov/21343310Test