المؤلفون: Coleman, Robert L, Oza, Amit M, Lorusso, Domenica, Aghajanian, Carol, Oaknin, Ana, Dean, Andrew, Colombo, Nicoletta, Weberpals, Johanne I, Clamp, Andrew, Scambia, Giovanni, Leary, Alexandra, Holloway, Robert W, Gancedo, Margarita Amenedo, Fong, Peter C, Goh, Jeffrey C, O'Malley, David M, Armstrong, Deborah K, Garcia-Donas, Jesus, Swisher, Elizabeth M, Floquet, Anne, Konecny, Gottfried E, McNeish, Iain A, Scott, Clare L, Cameron, Terri, Maloney, Lara, Isaacson, Jeff, Goble, Sandra, Grace, Caroline, Harding, Thomas C, Raponi, Mitch, Sun, James, Lin, Kevin K, Giordano, Heidi, Ledermann, Jonathan A, investigators, ARIEL3, Buck, M, Dean, A, Friedlander, ML, Goh, JC, Harnett, P, Kichenadasse, G, Scott, CL, Denys, H, Dirix, L, Vergote, I, Elit, L, Ghatage, P, Oza, AM, Plante, M, Provencher, D, Weberpals, JI, Welch, S, Floquet, A, Gladieff, L, Joly, F, Leary, A, Lortholary, A, Lotz, J, Medioni, J, Tredan, O, You, B, El-Balat, A, Hänle, C, Krabisch, P, Neunhöffer, T, Pölcher, M, Wimberger, P, Amit, A, Kovel, S, Leviov, M, Safra, T, Shapira-Frommer, R, Stemmer, S, Bologna, A, Colombo, N, Lorusso, D, Pignata, S, Sabbatini, RF, Scambia, G, Tamberi, S, Zamagni, C, Fong, PC, O'Donnell, A, Gancedo, M Amenedo, Herraez, A Casado, Garcia-Donas, J, Guerra, EM, Oaknin, A, Palacio, I, Romero, I, Sanchez, A, Banerjee, SN, Clamp, A, Drew, Y, Gabra, HG, Jackson, D, Ledermann, JA, McNeish, IA, Parkinson, C, Powell, M

المصدر: The Lancet. 390(10106)

مصطلحات موضوعية: Reproductive Medicine, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Orphan Drug, Clinical Research, Cancer, Genetics, Clinical Trials and Supportive Activities, Ovarian Cancer, Rare Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, 6.2 Cellular and gene therapies, Aged, Disease-Free Survival, Double-Blind Method, Female, Follow-Up Studies, Humans, Indoles, Internationality, Maintenance Chemotherapy, Middle Aged, Molecular Targeted Therapy, Neoplasm Recurrence, Local, Ovarian Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Risk Assessment, Survival Rate, Treatment Outcome, ARIEL3 investigators, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9xn4w6v7Test

المؤلفون: Grohmann, C, Walker, F, Devlin, M, Luo, MX, Chüeh, AC, Doherty, J, Vaillant, F, Ho, GY, Wakefield, MJ, Weeden, CE, Kamili, A, Murray, J, Po’uha, ST, Weinstock, J, Kane, SR, Faux, MC, Broekhuizen, E, Zheng, Y, Shield-Artin, K, Kershaw, NJ, Tan, CW, Witchard, HM, Ebert, G, Charman, SA, Street, I, Kavallaris, M, Haber, M, Fletcher, JI, Asselin-Labat, ML, Scott, CL, Visvader, JE, Lindeman, GJ, Watson, KG, Burgess, AW, Lessene, G

المصدر: urn:ISSN:2041-4889 ; Cell Death and Disease, 12, 3, 268

مصطلحات موضوعية: Rare Diseases, Biotechnology, Orphan Drug, Lung Cancer, Neurosciences, Ovarian Cancer, Neuroblastoma, Cancer, Breast Cancer, Genetics, Lung, 5 Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Antimitotic Agents, Apoptosis, Cell Proliferation, Drug Resistance, Neoplasm, Female, G2 Phase Cell Cycle Checkpoints, Hep G2 Cells, Humans, Mice, Inbred BALB C, Inbred C57BL, Nude, Mitosis, Neoplasms, PC-3 Cells

وصف الملف: application/pdf

العلاقة: http://purl.org/au-research/grants/nhmrc/APP1119152Test; http://hdl.handle.net/1959.4/unsworks_76233Test; https://unsworks.unsw.edu.au/bitstreams/8e5191f0-886b-4b2d-984c-dbe15394dcd8/downloadTest; https://doi.org/10.1038/s41419-020-03269-0Test

الإتاحة: https://doi.org/10.1038/s41419-020-03269-0Test
http://hdl.handle.net/1959.4/unsworks_76233Test
https://unsworks.unsw.edu.au/bitstreams/8e5191f0-886b-4b2d-984c-dbe15394dcd8/downloadTest

المؤلفون: Jung, M, Gao, J, Cheung, L, Bongers, A, Somers, K, Clifton, M, Ramsay, EE, Russell, AJ, Valli, E, Gifford, AJ, George, J, Kennedy, CJ, Wakefield, MJ, Topp, M, Ho, GY, Scott, CL, Bowtell, DD, deFazio, A, Norris, MD, Haber, M, Henderson, MJ

المصدر: urn:ISSN:0020-7136 ; urn:ISSN:1097-0215 ; International Journal of Cancer, 147, 8, 2225-2238

مصطلحات موضوعية: Cancer, Ovarian Cancer, Rare Diseases, Orphan Drug, 5.1 Pharmaceuticals, 5 Development of treatments and therapeutic interventions, Carcinoma, Endometrioid, Ovarian Epithelial, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cystadenocarcinoma, Serous, Drug Resistance, Neoplasm, Female, Gene Expression Regulation, Neoplastic, Genes, myc, Humans, Multidrug Resistance-Associated Proteins, Ovarian Neoplasms, Prognosis, RNA, Small Interfering, Survival Rate, ABCC4/MRP4

وصف الملف: application/pdf

العلاقة: http://purl.org/au-research/grants/nhmrc/APP1067110Test; http://hdl.handle.net/1959.4/unsworks_80419Test; https://unsworks.unsw.edu.au/bitstreams/cafa378b-e566-4efa-bf72-bbc3cca5523e/downloadTest; https://doi.org/10.1002/ijc.33005Test

الإتاحة: https://doi.org/10.1002/ijc.33005Test
http://hdl.handle.net/1959.4/unsworks_80419Test
https://unsworks.unsw.edu.au/bitstreams/cafa378b-e566-4efa-bf72-bbc3cca5523e/downloadTest

المؤلفون: McNeish, IA, Kondrashova, O, Topp, M, Nesic, K, Lieschke, E, Ho, G-Y, Harrell, MI, Zapparoli, GV, Hadley, A, Holian, R, Boehm, E, Heong, V, Sanij, E, Pearson, RB, Krais, JJ, Johnson, N, McNally, O, Ananda, S, Alsop, K, Hutt, KJ, Kaufmann, SH, Lin, KK, Harding, TC, Traficante, N, DeFazio, A, Bowtell, DD, Swisher, EM, Dobrovic, A, Wakefield, MJ, Scott, CL

المساهمون: Imperial College Healthcare NHS Trust- BRC Funding, Cancer Research UK

مصطلحات موضوعية: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, HOMOLOGOUS RECOMBINATION REPAIR, OLAPARIB MAINTENANCE THERAPY, SPORADIC BREAST-CANCER, POLYMERASE INHIBITORS, POLY(ADP-RIBOSE) POLYMERASE, PLATINUM RESPONSE, SOMATIC MUTATIONS, PROMOTER REGION, FALLOPIAN-TUBE, PHASE-2 TRIAL, Animals, Antineoplastic Agents, BRCA1 Protein, Cell Line, Tumor, Cisplatin, DNA Methylation, Female, Gene Dosage, Humans, Indoles, Kaplan-Meier Estimate, Mice, Inbred NOD, Knockout, SCID, Ovarian Neoplasms

العلاقة: Nature Communications; http://hdl.handle.net/10044/1/61797Test; https://dx.doi.org/10.1038/s41467-018-05564-zTest; RDB01; RG71079

الإتاحة: https://doi.org/10.1038/s41467-018-05564-zTest
http://hdl.handle.net/10044/1/61797Test

المؤلفون: Swisher, EM, Lin, KK, Oza, AM, Scott, CL, Giordano, H, Sun, J, Konecny, GE, Coleman, RL, Tinker, AV, O'Malley, DM, Kristeleit, RS, Ma, L, Bell-McGuinn, KM, Brenton, JD, Cragun, JM, Oaknin, A, Ray-Coquard, I, Harrell, MI, Mann, E, Kaufmann, SH, Floquet, A, Leary, A, Harding, TC, Goble, S, Maloney, L, Isaacson, J, Allen, AR, Rolfe, L, Yelensky, R, Raponi, M, McNeish, IA

المصدر: Lancet Oncology , 18 (1) pp. 75-87. (2017)

مصطلحات موضوعية: Aged, Antineoplastic Agents, BRCA1 Protein, BRCA2 Protein, Drug Resistance, Neoplasm, Fallopian Tube Neoplasms, Female, Follow-Up Studies, Germ-Line Mutation, Humans, Indoles, International Agencies, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Peritoneal Neoplasms, Platinum, Poly(ADP-ribose) Polymerase Inhibitors, Poly(ADP-ribose) Polymerases, Prognosis, Prospective Studies, Salvage Therapy, Survival Rate

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10049690/1/Kristeleit_ARIEL2_HRD_Manuscript_Lancet_Oncol_09Sep2016%28clean%29.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10049690Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10049690/1/Kristeleit_ARIEL2_HRD_Manuscript_Lancet_Oncol_09Sep2016%28clean%29.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10049690Test/

المؤلفون: Coleman, RL, Oza, AM, Lorusso, D, Aghajanian, C, Oaknin, A, Dean, A, Colombo, N, Weberpals, JI, Clamp, A, Scambia, G, Leary, A, Holloway, RW, Gancedo, MA, Fong, PC, Goh, JC, O'Malley, DM, Armstrong, DK, Garcia-Donas, J, Swisher, EM, Floquet, A, Konecny, GE, McNeish, IA, Scott, CL, Cameron, T, Maloney, L, Isaacson, J, Goble, S, Grace, C, Harding, TC, Raponi, M, Sun, J, Lin, KK, Giordano, H, Ledermann, JA, ARIEL3 investigators

المساهمون: Leidos Biomedical Research, Inc.

المصدر: 1961 ; 1949

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, EPITHELIAL OVARIAN, SOLID TUMORS, OPEN-LABEL, CANCER, CHEMOTHERAPY, HETEROZYGOSITY, MULTICENTER, BEVACIZUMAB, Aged, Disease-Free Survival, Double-Blind Method, Female, Follow-Up Studies, Humans, Indoles, Internationality, Maintenance Chemotherapy, Middle Aged, Molecular Targeted Therapy, Neoplasm Recurrence, Local, Ovarian Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Risk Assessment, Survival Rate

العلاقة: Lancet; http://hdl.handle.net/10044/1/53951Test; TCGA Pilot Program; 15Y011ST

الإتاحة: https://doi.org/10.1016/S0140-6736Test(17)32440-6
http://hdl.handle.net/10044/1/53951Test

المؤلفون: Swisher, EM, Lin, KK, Oza, AM, Scott, CL, Giordano, H, Sun, J, Konecny, GE, Coleman, RL, Tinker, AV, O'Malley, DM, Kristeleit, RS, Ma, L, Bell-McGuinn, KM, Brenton, JD, Cragun, JM, Oaknin, A, Ray-Coquard, I, Harrell, MI, Mann, E, Kaufmann, SH, Floquet, A, Leary, A, Harding, TC, Goble, S, Maloney, L, Isaacson, J, Allen, AR, Rolfe, L, Yelensky, R, Raponi, M, McNeish, IA

المصدر: 87 ; 75

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Oncology, HOMOLOGOUS RECOMBINATION DEFICIENCY, POLY(ADP-RIBOSE) POLYMERASE, GENOMIC LOSS, DNA-REPAIR, MUTANT-CELLS, CANCER, BREAST, HETEROZYGOSITY, OLAPARIB, TUMORS, Aged, Antineoplastic Agents, BRCA1 Protein, BRCA2 Protein, Carcinoma, Ovarian Epithelial, Drug Resistance, Neoplasm, Fallopian Tube Neoplasms, Female, Follow-Up Studies, Germ-Line Mutation, Humans, Indoles, International Agencies, Middle Aged, Neoplasm Recurrence

العلاقة: Lancet Oncology; http://hdl.handle.net/10044/1/54675Test

الإتاحة: https://doi.org/10.1016/s1470-2045Test(16)30559-9
http://hdl.handle.net/10044/1/54675Test

المؤلفون: Miller, RE, Leary, A, Scott, CL, Serra, V, Lord, CJ, Bowtell, D, Chang, DK, Garsed, DW, Jonkers, J, Ledermann, JA, Nik-Zainal, S, Ray-Coquard, I, Shah, SP, Matias-Guiu, X, Swisher, EM, Yates, LR

المساهمون: Nik-Zainal Abidin, Serena [0000-0001-5054-1727], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Ovarian Neoplasms, homologous recombination deficiency (HRD), genomic scar assays, poly-ADP ribose inhibitors (PARPi), BRCA, Humans, Female, Carcinoma, Ovarian Epithelial, Poly(ADP-ribose) Polymerase Inhibitors, Homologous Recombination, Biomarkers

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3a487d7dc9c28d291eaf3a50a39ad3Test

المؤلفون: Bowtell, DD, Boehm, S, Ahmed, AA, Aspuria, P-J, Bast, RC, Beral, V, Berek, JS, Birrer, MJ, Blagden, S, Bookman, MA, Brenton, JD, Chiappinelli, KB, Martins, FC, Coukos, G, Drapkin, R, Edmondson, R, Fotopoulou, C, Gabra, H, Galon, J, Gourley, C, Heong, V, Huntsman, DG, Iwanicki, M, Karlan, BY, Kaye, A, Lengyel, E, Levine, DA, Lu, KH, McNeish, IA, Menon, U, Narod, SA, Nelson, BH, Nephew, KP, Pharoah, P, Powell, DJ, Ramos, P, Romero, IL, Scott, CL, Sood, AK, Stronach, EA, Balkwill, FR

المصدر: 679 ; 668

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Oncology, BRCA MUTATION CARRIERS, TUBAL-INTRAEPITHELIAL-CARCINOMA, OLAPARIB MAINTENANCE THERAPY, SINGLE-THRESHOLD RULE, HUMAN BREAST-TUMORS, CELL LUNG-CANCER, FALLOPIAN-TUBE, T-CELLS, GERMLINE MUTATIONS, SOMATIC MUTATIONS, Cystadenocarcinoma, Serous, Female, Humans, Neoplasm Grading, Ovarian Neoplasms, Prognosis, Survival Rate, Oncology & Carcinogenesis, 11 Medical And Health Sciences

العلاقة: Nature Reviews Cancer; http://hdl.handle.net/10044/1/43637Test; https://dx.doi.org/10.1038/nrc4019Test

الإتاحة: https://doi.org/10.1038/nrc4019Test
http://hdl.handle.net/10044/1/43637Test