نتائج البحث - "Peter J. Mullen"

1

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

المصدر: Nature cancer, vol 3, iss 11
Nature Cancer

مصطلحات موضوعية: Cancer Research, Adenocarcinoma, Pancreatic Neoplasms, Pancreatic Cancer, Mice, Rare Diseases, Oncology, Tumor Microenvironment, 2.1 Biological and endogenous factors, Animals, Humans, Aetiology, Asparagine, Digestive Diseases, Symbiosis, Nutrition, Cancer

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d1d8ab8d7e4958d9992ca11db28b89Test
https://doi.org/10.1038/s43018-022-00463-1Test

2

Methionine restriction forces Epstein-Barr virus out of latency

المؤلفون: Sriraksha Bharadwaj Kashyap, Racheal Mulondo, Peter J. Mullen

المصدر: Cell metabolism. 34(9)

مصطلحات موضوعية: Epstein-Barr Virus Infections, Herpesvirus 4, Human, Methionine, Physiology, Humans, Cell Biology, Molecular Biology, Virus Latency

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf751375f4bf59a3174c75f30514b5ebTest
https://pubmed.ncbi.nlm.nih.gov/36070681Test

3

A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer

المؤلفون: Najia Khurram, Peter J. Mullen, Robert J. Hamilton, Sangeet Ghai, Mohamad Elbaz, Joseph Longo, Theodorus van der Kwast, Emily Branchard, Neil Fleshner, Mehdi Masoomian, Linda Z. Penn, Eric Chen, Karen Hersey, Dianne Chadwick, David W. Andrews

المصدر: Prostate Cancer and Prostatic Diseases

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Cancer therapy, Urology, medicine.medical_treatment, Apoptosis, Pilot Projects, Article, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Prostate, Preoperative Care, Biopsy, Biomarkers, Tumor, medicine, Humans, Fluvastatin, Aged, Prostatectomy, medicine.diagnostic_test, Caspase 3, business.industry, Prostatic Neoplasms, Middle Aged, medicine.disease, Neoadjuvant Therapy, 3. Good health, Ki-67 Antigen, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Disease Progression, Immunohistochemistry, Hydroxymethylglutaryl CoA Reductases, business, medicine.drug, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928230d134347a4cfd7a1d049f2ee4c2Test
https://doi.org/10.1038/s41391-020-0221-7Test

4

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

المؤلفون: Nedas Matulionis, Peter J. Mullen, Arunachalam Ramaiah, Chandani Sen, Samuel W. French, Vaithilingaraja Arumugaswami, Ernst W. Schmid, Robert Damoiseaux, Kathrin Plath, Milica Momcilovic, Brigitte N. Gomperts, David B. Shackelford, Arunima Purkayastha, Gustavo Garcia, Justin Langerman, Heather R. Christofk

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature communications, vol 12, iss 1

مصطلحات موضوعية: 0301 basic medicine, viruses, Glutamine, General Physics and Astronomy, mTORC1, Virus Replication, 0302 clinical medicine, Chlorocebus aethiops, 2.1 Biological and endogenous factors, Aetiology, skin and connective tissue diseases, Lung, Multidisciplinary, respiratory system, Pyruvate carboxylase, Cell biology, Infectious Diseases, Mechanisms of disease, 5.1 Pharmaceuticals, TOR signalling, Benzamides, Respiratory, Mucosal immunology, Development of treatments and therapeutic interventions, Infection, Science, Morpholines, Citric Acid Cycle, Biology, Mechanistic Target of Rapamycin Complex 1, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, Animals, Humans, Naphthyridines, Protein Kinase Inhibitors, Vero Cells, Pyruvate Carboxylase, SARS-CoV-2, HEK 293 cells, COVID-19, Pneumonia, General Chemistry, Metabolism, biochemical phenomena, metabolism, and nutrition, respiratory tract diseases, 030104 developmental biology, Glucose, HEK293 Cells, Pyrimidines, Viral replication, Cell culture, Viral infection, Vero cell, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac75753ea6cfdc1e6711e570eefe016eTest
https://pubmed.ncbi.nlm.nih.gov/33767183Test

5

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins

المؤلفون: Peter J. Mullen, Rosemary Yu, Jenna E. van Leeuwen, Wail Ba-alawi, Joseph Longo, Linda Z. Penn, Benjamin Haibe-Kains

المصدر: Cancer Research. 78:1347-1357

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Epithelial-Mesenchymal Transition, Statin, medicine.drug_class, Protein Prenylation, Farnesyl pyrophosphate, Mevalonic Acid, Apoptosis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Polyisoprenyl Phosphates, Prenylation, Neoplasms, Biomarkers, Tumor, Tumor Cells, Cultured, medicine, Humans, HRAS, Fluvastatin, Cell Proliferation, Zinc Finger E-box-Binding Homeobox 1, 3. Good health, 030104 developmental biology, Oncology, chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer cell, ras Proteins, Cancer research, Protein prenylation, lipids (amino acids, peptides, and proteins), Ras superfamily, Sesquiterpenes, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172d0af6f57cd0142de641e82bd842fdTest
https://doi.org/10.1158/0008-5472.can-17-1231Test

6

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

المؤلفون: David B. Shackelford, Steven D. Mittelman, Ernst W. Schmid, Peter J. Mullen, Milica Momcilovic, Simon R.V. Knott, Abigail S. Krall, Apisadaporn Thambundit, Heather R. Christofk, Felicia Surjono, Costas A. Lyssiotis, Christopher J. Halbrook

المصدر: Cell metabolism, vol 33, iss 5

مصطلحات موضوعية: 0301 basic medicine, Physiology, cancer metabolism, mTORC1, Medical Biochemistry and Metabolomics, Mice, chemistry.chemical_compound, 0302 clinical medicine, Mice, Inbred NOD, Neoplasms, Asparagine, Cancer, Tumor, Nucleotides, Chemistry, asparagine, Metformin, Mitochondria, Survival Rate, Biochemistry, Intracellular, Asparaginase, Context (language use), Mechanistic Target of Rapamycin Complex 1, cancer treatment, Cell Line, Endocrinology & Metabolism, 03 medical and health sciences, Cell Line, Tumor, Respiration, Animals, Humans, Molecular Biology, Cell Proliferation, Aspartic Acid, Cell growth, ATF4, dietary restriction, Cell Biology, asparaginase, Activating Transcription Factor 4, Diet, 030104 developmental biology, Electron Transport Chain Complex Proteins, Inbred NOD, Biochemistry and Cell Biology, respiration, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ff698e1ed01342f983891c97c95357Test
https://doi.org/10.1016Test/j.cmet.2021.02.001

7

The interplay between cell signalling and the mevalonate pathway in cancer

المؤلفون: Peter J. Mullen, Rosemary Yu, Michael C. Archer, Joseph Longo, Linda Z. Penn

المصدر: Nature Reviews Cancer. 16:718-731

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44579fb2e893e634174ba9ab66ffe337Test
https://doi.org/10.1038/nrc.2016.76Test

8

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

المؤلفون: William J. Sullivan, Milica Momcilovic, Daniel Braas, Utpal Banerjee, Andrew E. Whiteley, Ernst W. Schmid, David Jelinek, William E. Lowry, Peter J. Mullen, Matthew B. Maxwell, Mark S. Sharpley, Hilary A. Coller, Donald E. Ayer, David B. Shackelford, Thomas Q. de Aguiar Vallim, Blake R. Wilde, Aimee Flores, Heather R. Christofk

المصدر: Cell, vol 175, iss 1

مصطلحات موضوعية: 0301 basic medicine, cell migration, extracellular matrix, glucose metabolism, 1.1 Normal biological development and functioning, Hyaluronoglucosaminidase, hyaluronidase, Biology, Medical and Health Sciences, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, receptor tyrosine kinase signaling, Extracellular matrix, 03 medical and health sciences, Tristetraprolin, Underpinning research, Cell Line, Tumor, cell biology, Humans, Glycolysis, Hyaluronic Acid, ZFP36, Cancer, Glucose Transporter Type 1, Tumor, Glucose transporter, Cell migration, Biological Sciences, Cell biology, Extracellular Matrix, 030104 developmental biology, Glucose, GLUT1 trafficking, mRNA degradation, biology.protein, Intercellular Signaling Peptides and Proteins, Carbohydrate Metabolism, GLUT1, Signal transduction, Carrier Proteins, TXNIP, Signal Transduction, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c96199e1b89ffdcbcc9314a9aa530bTest
https://escholarship.org/uc/item/3x99h8gqTest

9

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

المؤلفون: Karl S. Lang, Janice T. Pong, Peter J. Mullen, Elke Ericson, Jason Moffat, Corey Nislow, Kevin R. Brown, Rosemary Yu, Traver Hart, Aleksandra A. Pandyra, Piyush Sharma, Marinella Gebbia, Manpreet Kalkat, Guri Giaever, Carolyn A. Goard, Linda Z. Penn

المصدر: Oncotarget

مصطلحات موضوعية: Hydroxymethylglutaryl-CoA Synthase, Indoles, Lung Neoplasms, Medizin, Mevalonic Acid, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Mevalonic acid, Biology, Real-Time Polymerase Chain Reaction, statins, Small hairpin RNA, Fatty Acids, Monounsaturated, chemistry.chemical_compound, feedback inhibition, RNA interference, Cell Line, Tumor, Neoplasms, Farnesyltranstransferase, Humans, RNA, Small Interfering, Fluvastatin, Transcription factor, Cell Proliferation, Gene knockdown, mevalonate pathway, Geranyltranstransferase, Dimethylallyltranstransferase, Molecular biology, Gene Expression Regulation, Neoplastic, Oncology, chemistry, Cancer research, lipids (amino acids, peptides, and proteins), tumor metabolism, Female, Hydroxymethylglutaryl CoA Reductases, RNA Interference, GGPS1, Mevalonate pathway, SREBP2, Research Paper, Sterol Regulatory Element Binding Protein 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461f085c99e7d15a9c40fd98cab6e0ccTest
http://europepmc.org/articles/PMC4694962Test

10

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

المؤلفون: Peter J. Mullen, Ahmed Aman, Linda Z. Penn, Benjamin Haibe-Kains, Aaliya Tamachi, Wail Ba-alawi, Rima Al-awar, David W. Cescon, Cornelia Redel, Cheryl H. Arrowsmith, Yu-Jia Shiah, Dharmendra Dingar, Brian Raught, William B. Tu, Corey Lourenco, Paul C. Boutros

المصدر: Cancer cell. 34(4)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f0fd34332be5f88813a6d939006c6aTest
https://pubmed.ncbi.nlm.nih.gov/30367118Test

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