المؤلفون: Nataliia Petruk, Malin Åkerfelt, Gennady G. Yegutkin, Jesse Mattsson, Sanni Tuominen, Arja Jukkola, Johanna Tuomela, Jouko Sandholm, Katri S. Selander, Matthias Nees

المساهمون: Tampere University, Department of Oncology, Clinical Medicine

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

مصطلحات موضوعية: Adenosine monophosphate, Epithelial-Mesenchymal Transition, Lung Neoplasms, Science, Cell, 3122 Cancers, Mammary Neoplasms, Animal, Triple Negative Breast Neoplasms, GPI-Linked Proteins, Article, Small hairpin RNA, chemistry.chemical_compound, Mice, Breast cancer, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Cell migration, Epithelial–mesenchymal transition, Neoplasm Metastasis, 5'-Nucleotidase, Mice, Inbred BALB C, Multidisciplinary, Adenosine, Neoplasm Proteins, medicine.anatomical_structure, chemistry, Tumor progression, Cancer cell, Cancer research, Medicine, Female, medicine.drug

وصف الملف: fulltext

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adec61e67ea321b05fbc366bc9163aaTest
http://europepmc.org/articles/PMC7966763Test

المؤلفون: Ulf-Håkan Stenman, Jouni Jokela, Hannu Koistinen, Kaarina Sivonen, Antti Poso, Matti Wahlsten, Perttu Permi, David P. Fewer, Tomas Strandin, Danillo O. Alvarenga, Matthias Nees, Mikko Metsä-Ketelä, Muhammad N. Ahmed

المساهمون: Department of Microbiology, Faculty of Agriculture and Forestry, Department of Food and Nutrition, Cyanobacteria research, Department of Clinical Chemistry and Hematology, Department of Virology, Medicum, Viral Zoonosis Research Unit, Helsinki Institute of Sustainability Science (HELSUS), Chemistry Teacher Education Unit (Department of Chemistry) (-2009), Institute of Biotechnology, HUS Abdominal Center, Faculty Common Matters (Faculty of Biology and Environmental Sciences), Microbial Natural Products

المصدر: ACS Chemical Biology
Ahmed, M N, Wahlsten, M, Jokela, J, Nees, M, Stenman, U-H, Alvarenga, D O, Strandin, T, Sivonen, K, Poso, A, Permi, P, Metsä-Ketelä, M, Koistinen, H & Fewer, D P 2021, ' Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products ', ACS chemical biology, vol. 16, no. 11, pp. 2537–2546 . https://doi.org/10.1021/acschembio.1c00611Test

مصطلحات موضوعية: Proteases, serine proteases, 116 Chemical sciences, proteaasi, luonnontuotteet, 01 natural sciences, Biochemistry, Genome, proteomiikka, Serine, 03 medical and health sciences, Cell Line, Tumor, Gene cluster, inhibitors, Humans, IC50, Gene, trypsiinit, 030304 developmental biology, Cell Proliferation, inhibiittorit, Serine protease, 0303 health sciences, Biological Products, biology, biokemia, 010405 organic chemistry, Cell growth, Chemistry, bioinformatiikka, General Medicine, Articles, seriiniproteaasi, 0104 chemical sciences, 3. Good health, syöpäsolut, Genes, Bacterial, biology.protein, Molecular Medicine, proteases, syöpätaudit, proteiinit, Trypsin Inhibitors, Azabicyclo Compounds, Nodularia, Aeruginosins

وصف الملف: application/pdf; fulltext

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dab7b1e75d58c8c8668582248387f2Test
http://urn.fi/URN:NBN:fi:jyu-202110205299Test

المؤلفون: Mervi Toriseva, Kaisa K. Ivaska, Ilkka Koskivuo, Tiina E. Kähkönen, Peter J. Boström, A. Maher, J. Kaivola, A.-R. Virta, Johanna Tuomela, Matthias Nees, Natalija Eigeliene, Nataliia Petruk, Pirkko Härkönen

المصدر: Cellular Oncology (Dordrecht)

مصطلحات موضوعية: Cancer Research, Cell Survival, Radio-sensitization, Caspase 3, Breast Neoplasms, Biology, Quinolones, FGFR Gene Amplification, Piperazines, Tissue Culture Techniques, Breast cancer, Cell Movement, Cell Line, Tumor, Humans, Explant culture, Neoplasm Invasiveness, Protein Kinase Inhibitors, Cell Proliferation, Original Paper, Cell Death, Fibroblast growth factor receptor 1, Phenylurea Compounds, Receptor Protein-Tyrosine Kinases, General Medicine, Fibroblast growth factor receptor inhibitor, 2D/3D cell culture, Fibroblast growth factor receptor, Blot, Organoids, Pyrimidines, Oncology, Apoptosis, Cell culture, Benzamides, Cancer research, Molecular Medicine, Pyrazoles, Benzimidazoles, Female, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a69c35b46d32af6aee5ac4deada735Test
https://pubmed.ncbi.nlm.nih.gov/33119860Test

المؤلفون: Adolfo Rivero-Müller, Matthias Nees

المصدر: EMBO Reports

مصطلحات موضوعية: 0303 health sciences, 4. Education, S&S: History & Philosophy of Science, Radiation-Protective Agents, Methods & Resources, Empirical Research, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Empirical research, ComputingMilieux_COMPUTERSANDEDUCATION, Genetics, Humans, Engineering ethics, Amino Acid Sequence, Sociology, Students, Science & Society, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5147895e6789c89ccd28ec97af6d4aTest
https://doi.org/10.15252/embr.201949004Test

المؤلفون: Ciro Abbondanza, Mariarosaria Conte, Angela Nebbioso, Vincenzo Carafa, Lucia Altucci, Gabriella Lania, Valeria Belsito Petrizzi, Francesco Iovino, Francesco Paolo Tambaro, Hendrik G. Stunnenberg, Concetta Ingenito, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Guillermo Garcia-Manero, Joost H.A. Martens, Saverio Minucci

المساهمون: Nebbioso, Angela, Carafa, Vincenzo, Conte, Mariarosaria, Tambaro, Francesco Paolo, Abbondanza, Ciro, Martens, Joost H. A, Nees, Matthia, Benedetti, Rosaria, Pallavicini, Isabella, Minucci, Saverio, Garcia Manero, G, Iovino, Francesco, Lania, Gabriella, Ingenito, Concetta, Belsito Petrizzi, Valeria, Stunnenberg, Hendrik G, Altucci, Lucia

المصدر: Clinical cancer research
23 (2016): 2542–2555. doi:10.1158/1078-0432.CCR-15-2388
info:cnr-pdr/source/autori:Nebbioso A., Carafa V, Conte M, Tambaro FP, Abbondanza C, Martens JH, Nees M, Benedetti R, Pallavicini I, Minucci S, Garcia-Manero G, Iovino F, Lania G, Ingenito C, Belsito Petrizzi V, Stunnenberg HG, Altucci L./titolo:c-Myc modulation & acetylation is a key HDAC inhibitor target in cancer/doi:10.1158%2F1078-0432.CCR-15-2388/rivista:Clinical cancer research (Print)/anno:2016/pagina_da:2542/pagina_a:2555/intervallo_pagine:2542–2555/volume:23
Clinical Cancer Research, 23, 2542-2555
Clinical Cancer Research, 23, 10, pp. 2542-2555

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Sp1 Transcription Factor, Kruppel-Like Transcription Factors, Histone Deacetylase 1, Proto-Oncogene Proteins c-myc, TNF-Related Apoptosis-Inducing Ligand, 03 medical and health sciences, Cell Line, Tumor, Neoplasms, hemic and lymphatic diseases, medicine, Humans, Molecular Biology, Regulation of gene expression, Clinical Trials as Topic, Gene Expression Regulation, Leukemic, business.industry, Myeloid leukemia, Cancer, Acetylation, medicine.disease, c-Myc modulation, 3. Good health, Histone Deacetylase Inhibitors, Leukemia, 030104 developmental biology, Oncology, Apoptosis, Immunology, Cancer cell, Cancer research, Histone deacetylase, business, Ex vivo, Protein Binding, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9574b9aa831c211f48b337e4a785778Test
https://hdl.handle.net/2066/165880Test

المؤلفون: Assunta Sellitto, Valerio Gigantino, Malin Åkerfelt, Giorgio Giurato, Annamaria Salvati, Eugenio Morelli, Tuula A. Nyman, Domenico Memoli, Giovanni Nassa, Luciano Milanesi, Donatella Malanga, Elena Alexandrova, Sara Kangaspeska, Alessandro Weisz, Teresa Mirante, Matthias Nees, Francesca Rizzo, Roberta Tarallo

المصدر: Science Advances (2019). doi:10.1126/sciadv.aav5590
info:cnr-pdr/source/autori:Nassa G, Salvati A, Tarallo R, Gigantino V, Alexandrova E, Memoli D, Sellitto A, Rizzo F, Malanga D, Mirante T, Morelli E, Nees M, Åkerfelt M, Kangaspeska S, Nyman TA, Milanesi L, Giurato G, Weisz A./titolo:Inhibition of histone methyltransferase DOT1L silences ER? gene and blocks proliferation of antiestrogen-resistant breast cancer cells/doi:10.1126%2Fsciadv.aav5590/rivista:Science Advances/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume
Science Advances

مصطلحات موضوعية: Methyltransferase, Transcription, Genetic, Estrogen receptor, Mice, Breast cancer, 0302 clinical medicine, Estrogen Receptor Modulators, skin and connective tissue diseases, Research Articles, Cancer, 0303 health sciences, Multidisciplinary, SciAdv r-articles, breast cancer, epigenetics, targeted therapy, bioinformatics, targeted therapy, Chromatin, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Female, hormones, hormone substitutes, and hormone antagonists, Research Article, Protein Binding, Signal Transduction, Breast Neoplasms, Biology, ta3111, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Gene silencing, Gene Silencing, Epigenetics, Cell Proliferation, 030304 developmental biology, epigenetics, endocrine therapy, Estrogen Receptor alpha, Cell Cycle Checkpoints, Histone-Lysine N-Methyltransferase, DOT1L, ta3122, Antiestrogen, Xenograft Model Antitumor Assays, Disease Models, Animal, Drug Resistance, Neoplasm, Cancer research, FOXA1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12df41a9e947b7606ac2861f63f9f068Test
https://doi.org/10.1126/sciadv.aav5590Test

المؤلفون: Jenny Joutsen, Fang Cheng, Mikael C. Puustinen, Johanna K. Björk, Lea Sistonen, Malin Åkerfelt, Matthias Nees

المصدر: Björk, J K, Åkerfelt, M, Joutsen, J, Puustinen, M C, Cheng, F, Sistonen, L & Nees, M 2016, ' Heat-shock factor 2 is a suppressor of prostate cancer invasion ', Oncogene, vol. 35, no. 14, pp. 1770-84 . https://doi.org/10.1038/onc.2015.241Test
Oncogene

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Biology, medicine.disease_cause, ta3111, Metastasis, Mice, RHO signalling, 03 medical and health sciences, Prostate cancer, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Biomarkers, Tumor, Genetics, medicine, Animals, Humans, metastasis, Neoplasm Invasiveness, Neoplasm Metastasis, HSF1, Cell adhesion, Molecular Biology, Heat-Shock Proteins, Actin, ta1184, ta1182, Prostatic Neoplasms, Cancer, Cell Differentiation, prostate cancer, medicine.disease, Actin cytoskeleton, ta3122, Xenograft Model Antitumor Assays, Cell biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Tumor progression, Original Article, Neoplasm Grading, Carcinogenesis, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1086c344a0abcd5eeff393db512281fdTest
http://juuli.fi/Record/0006694915Test

المؤلفون: Hannu-Pekka Schukov, Matthias Nees, Janne Heikkilä, Malin Åkerfelt, Sean Robinson, Raija Sormunen, Neslihan Bayramoglu, Johannes Virtanen, Juho Kannala, Mika Kaakinen, Mervi Toriseva, Ville Härmä, Lauri Eklund

المساهمون: Turku Centre for Biotechnology, University of Turku-Åbo Academy University, University of Turku, Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), VTT Technical Research Centre of Finland (VTT), Machine Vision Group (MVG), University of Oulu, Center for Machine Vision Research (CMV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

المصدر: Oncotarget
Oncotarget, Impact journals, 2015, 6 (30), ⟨10.18632/oncotarget.5046⟩
Oncotarget, 2015, 6 (30), ⟨10.18632/oncotarget.5046⟩
Åkerfelt, M, Bayramoglu, N, Robinson, S, Toriseva, M, Schukov, H-P, Härmä, V, Virtanen, J, Sormunen, R, Kaakinen, M, Kannala, J, Eklund, L, Heikkilä, J & Nees, M 2015, ' Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention ', Oncotarget, vol. 6, no. 30, pp. 30035-30056 . https://doi.org/10.18632/oncotarget.5046Test

مصطلحات موضوعية: Male, [SDV]Life Sciences [q-bio], focal adhesion kinase (FAK), Cell Culture Techniques, Cell Communication, Prostate cancer, 0302 clinical medicine, Cell Movement, Tumor Microenvironment, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Microscopy, Confocal, 3D co-culture, invasion, University hospital, 3. Good health, Oncology, Cell Tracking, Research centre, 030220 oncology & carcinogenesis, Collagen, Algorithms, Research Paper, Cancer associated fibroblast, ta3111, Models, Biological, Time-Lapse Imaging, Cell Line, 03 medical and health sciences, Microscopy, Electron, Transmission, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Humans, Tumor growth, Tumor stroma, Protein Kinase Inhibitors, Cell Proliferation, 030304 developmental biology, ta113, Tumor histology, Tumor microenvironment, cancer associated fibroblast (CAF), business.industry, phenotypic screening, ta1182, Granulocyte-Macrophage Colony-Stimulating Factor, Prostatic Neoplasms, Fibroblasts, ta3122, medicine.disease, Coculture Techniques, Focal Adhesion Protein-Tyrosine Kinases, Cancer research, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93326a6d15c89889a4ac7e1d2f45097Test
https://doi.org/10.18632/oncotarget.5046Test

المؤلفون: Malin Åkerfelt, Matthias Nees, Jonathan Waxman, Irantzu Gorroño-Etxebarria, Virginia Murillo-Garzón, Mikael C. Puustinen, James Carton, Lea Sistonen, Robert M. Kypta

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Male, Frizzled, General Physics and Astronomy, Smad Proteins, Prostate cancer, Transforming Growth Factor beta, Neoplasm Metastasis, lcsh:Science, WNT/BETA-CATENIN, Multidisciplinary, Wnt signaling pathway, TGF-BETA, prostate cancer, CONVERGENT EXTENSION MOVEMENTS, Multidisciplinary Sciences, embryonic structures, Science & Technology - Other Topics, Signal transduction, Signal Transduction, Epithelial-Mesenchymal Transition, animal structures, Science, NONCANONICAL WNT, Receptors, Cell Surface, MAJOR ROLE, Biology, General Biochemistry, Genetics and Molecular Biology, Article, MECHANISMS, 03 medical and health sciences, Wnt, Cell Line, Tumor, TGF beta signaling pathway, MD Multidisciplinary, medicine, Humans, XENOPUS-LAEVIS, Neoplasm Invasiveness, Epithelial–mesenchymal transition, Gene Silencing, MESENCHYMAL TRANSITION, Science & Technology, Activating Transcription Factor 2, Cell growth, Prostatic Neoplasms, General Chemistry, Transforming growth factor beta, medicine.disease, Wnt Proteins, 030104 developmental biology, CELLS, biology.protein, Cancer research, lcsh:Q, sense organs, TRANSCRIPTIONAL ACTIVATION, Receptors, Transforming Growth Factor beta

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098e23af2a5c7228f627f020758dfaf0Test
http://hdl.handle.net/10044/1/57704Test

المؤلفون: Malin, Åkerfelt, Mervi, Toriseva, Matthias, Nees

المصدر: Methods in molecular biology (Clifton, N.J.). 1612

مصطلحات موضوعية: Organoids, Epithelial-Mesenchymal Transition, Phenotype, Cell Line, Tumor, Cell Culture Techniques, Image Processing, Computer-Assisted, Tumor Microenvironment, Humans, Epithelial Cells, Software, Cell Proliferation, Extracellular Matrix

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::4c4e36e1c7277dc0a6c4036728070ce3Test
https://pubmed.ncbi.nlm.nih.gov/28634961Test