المؤلفون: Celine Posseme, Alba Llibre, Bruno Charbit, Vincent Bondet, Vincent Rouilly, Violaine Saint-André, Jeremy Boussier, Jacob Bergstedt, Nikaïa Smith, Liam Townsend, Jamie A. Sugrue, Clíona Ní Cheallaigh, Niall Conlon, Maxime Rotival, Michael S. Kobor, Estelle Mottez, Stanislas Pol, Etienne Patin, Matthew L. Albert, Lluis Quintana-Murci, Darragh Duffy, Laurent Abel, Andres Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf-Bensussan, Ana Cumano, Caroline Demangel, null Christophe d’Enfert, Ludovic Deriano, Marie-Agnès Dillies, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Magnus Fontes, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A. Ingersoll, Rose Anne Kenny, Olivier Lantz, Mickael Ménager, Frédérique Michel, Hugo Mouquet, Cliona O'Farrelly, Sandra Pellegrini, Antonio Rausell, Frédéric Rieux-Laucat, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Christophe Zimmer

المساهمون: Immunologie Translationnelle - Translational Immunology lab, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Ecole Doctorale Frontiere de l’Innovation en Recherche et Education (ED 474 FIRE), Université Paris Cité (UPCité)-Université Paris sciences et lettres (PSL), Cytometrie et Biomarqueurs – Cytometry and Biomarkers (UTechS CB), Datactix, Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), St James’s Hospital [Dublin, Ireland], Trinity College Dublin, University of British Columbia [Vancouver], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), HIBIO [South San Francisco], Collège de France - Chaire Génomique humaine et évolution, Collège de France (CdF (institution)), This study was funded with support from the French Governments Investissement dAvenir Program, Laboratoire Excellence Milieu Interieur Grant ANR-10-LABX-69-01 and by an Agence National de Recherche foundation grant (CE17001002)., The Milieu Intérieur Consortium is composed of the following team leaders: Laurent Abel (Hôpital Necker), Andres Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke (Trinity College Dublin), Petter Brodin (Karolinska Institutet), Pierre Bruhns, Nadine Cerf-Bensussan (INSERM UMR 1163 – Institut Imagine), Ana Cumano, Caroline Demangel, Christophe d’Enfert, Ludovic Deriano, Marie-Agnès Dillies, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay (EPFL, Lausanne), Ivo Gomperts-Boneca, Milena Hasan, Magnus Fontes (Institut Roche), Gunilla Karlsson Hedestam (Karolinska Institutet), Serge Hercberg (Université Paris 13), Molly Ingersoll, Rose Anne Kenny (Trinity College Dublin), Olivier Lantz (Institut Curie), Frédérique Michel, Hugo Mouquet, Cliona O'Farrelly (Trinity College Dublin), Etienne Patin, Sandra Pellegrini, Stanislas Pol (Hôpital Côchin), Antonio Rausell (INSERM UMR 1163 – Institut Imagine), Frédéric Rieux-Laucat (INSERM UMR 1163 – Institut Imagine), Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert (Hôpital Saint-Louis), Mathilde Touvier (Université Paris 13), Marie-Noëlle Ungeheuer, Christophe Zimmer, Matthew L. Albert (In Sitro), Darragh Duffy, Lluis Quintana-Murci, ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), ANR-20-CE17-0010,ELECTRO,Inhibition de l'Exchange Protein directly activated by cAMP -1 pour traiter la Fibrillation Atrial(2020), Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute-University of British Columbia (UBC), University of Cape Town, Département d'hépatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Insitro [San Francisco], St James's University Hospital, Leeds Teaching Hospitals NHS Trust, University of British Columbia (UBC), This study was funded with support from the French Government’s Investissement d’Avenir Program, Laboratoire d’Excellence 'Milieu Intérieur' grant ANR-10-LABX-69-01, and by an Agence National de Recherche Foundation grant (CE17001002). We thank the UTechS CB of the Center for Translational Research, Institut Pasteur for supporting data generation, Pierre-Henri Commere for help with flow cytometry sorting, Aurelie Bisiaux for flow cytometry advice, and Dr. Molly Ingersoll for scientific advice and critical reading of the manuscript. D.D. thanks Immunoqure for provision of the mAbs under an MTA for the Simoa IFNα assay. We thank the STTAR-Bioresource of TCD-SJH-TUH COVID-19 bioresource, which supported collection of COVID-19 patient samples, and the 'URGENCE COVID-19' fundraising campaign of the Institut Pasteur (CoVarImm and Steroid Response) for supporting data generation of COVID-19 samples. N.S. is a recipient of the Pasteur-Roux-Cantarini Fellowship. N.C. and C.N.C. are part funded by a Science Foundation Ireland (SFI) grant, grant code 20/SPP/3685. L.T. is supported by the Irish Clinical Academic Training (ICAT) Program, supported by the Wellcome Trust and the Health Research Board (grant number 203930/B/16/Z), the Health Service Executive, National Doctors Training and Planning, and the Health and Social Care, Research and Development Division, Northern Ireland., Milieu Intérieur Consortium: Laurent Abel, Andres Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf-Bensussan, Ana Cumano, Caroline Demangel, Christophe d'Enfert, Ludovic Deriano, Marie-Agnès Dillies, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Magnus Fontes, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A Ingersoll, Rose Anne Kenny, Olivier Lantz, Mickael Ménager, Frédérique Michel, Hugo Mouquet, Cliona O'Farrelly, Etienne Patin, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Frédéric Rieux-Laucat, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Christophe Zimmer, Matthew L Albert, Darragh Duffy, Lluis Quintana-Murci, ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010)

المصدر: Cell Reports
Cell Reports, 2022, 39 (13), pp.110989. ⟨10.1016/j.celrep.2022.110989⟩
Cell Reports, 2022, ⟨10.1016/j.celrep.2022.110989⟩

مصطلحات موضوعية: Lipopolysaccharides, Proteomics, History, Polymers and Plastics, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Disease, systems immunology, Biology, General Biochemistry, Genetics and Molecular Biology, Industrial and Manufacturing Engineering, Immune system, medicine, Humans, Secretion, Epigenetics, Business and International Management, Epigenomics, TLR4 immune responses, Systems immunology, SARS-CoV-2, COVID-19, CP: Immunology, Interferon-beta, Interleukin-12, Toll-Like Receptor 4, Cytokine, IL-12p70, type I interferons, Immunology, TLR4, Cytokine variability, [SDV.IMM]Life Sciences [q-bio]/Immunology, Cytokines

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b042088ef7d350f52ea9e615b9035d6fTest
https://pubmed.ncbi.nlm.nih.gov/35767946Test

المؤلفون: Lluis Quintana-Murci, Bruno Charbit, Antonio Rausell, Darragh Duffy, Caron B, Matthew L. Albert, Etienne Patin, Maxime Rotival

المساهمون: The Clinical Bioinformatics laboratory (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Cytometrie et Biomarqueurs – Cytometry and Biomarkers (UTechS CB), Institut Pasteur [Paris], Insitro [San Francisco], Chaire Génomique humaine et évolution, Collège de France (CdF (institution)), Immunologie Translationnelle - Translational Immunology lab, Service de génétique moléculaire [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This work benefited from support of the French government's Invest in the Future programme. This programme is managed by the Agence Nationale de la Recherche, reference ANR-10-LABX-69-01. The Clinical Bioinformatics Laboratory of the Imagine Institute was partly supported by the French National Research Agency (ANR) 'Investissements d’Avenir' Program (Grant ANR-10-IAHU-01)., ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), ANR-10-IAHU-0001,Imagine,Institut Hospitalo-Universitaire Imagine(2010), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), HIBIO [South San Francisco], Collège de France - Chaire Génomique humaine et évolution, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), The study is sponsored by Institut Pasteur (Pasteur ID-RCB Number: 2012-A00238-35) and was conducted as a single-center interventional study without an investigational product. This work benefited from support of the French government’s Invest in the Future program. This program is managed by the Agence Nationale de la Recherche, reference ANR-10-LABX-69-01. The Clinical Bioinformatics Laboratory of the Imagine Institute was partly supported by the French National Research Agency (ANR) 'Investissements d’Avenir' Program (Grant ANR-10-IAHU-01)., The Milieu Intérieur Consortium is composed of the following team leaders: Laurent Abel (Hôpital Necker), Andres Alcover (Institut Pasteur), Hugues Aschard (Institut Pasteur), Philippe Bousso (Institut Pasteur), Nollaig Bourke (Trinity College Dublin), Petter Brodin (Karolinska Institutet), Pierre Bruhns (Institut Pasteur), Nadine Cerf-Bensussan (INSERM UMR 1163 – Institut Imagine), Ana Cumano (Institut Pasteur), Caroline Demangel (Institut Pasteur), Christophe d’Enfert (Institut Pasteur), Ludovic Deriano (Institut Pasteur), Marie-Agnès Dillies (Institut Pasteur), James Di Santo (Institut Pasteur), Françoise Dromer (Institut Pasteur), Gérard Eberl (Institut Pasteur), Jost Enninga (Institut Pasteur), Jacques Fellay (EPFL, Lausanne), Ivo Gomperts-Boneca (Institut Pasteur), Milena Hasan (Institut Pasteur), Magnus Fontes (Institut Roche), Gunilla Karlsson Hedestam (Karolinska Institutet), Serge Hercberg (Université Paris 13), Molly A Ingersoll (Institut Pasteur), Rose Anne Kenny (Trinity College Dublin), Olivier Lantz (Institut Curie), Frédérique Michel (Institut Pasteur), Hugo Mouquet (Institut Pasteur), Cliona O'Farrelly (Trinity College Dublin), Etienne Patin (Institut Pasteur), Sandra Pellegrini (Institut Pasteur), Stanislas Pol (Hôpital Côchin), Antonio Rausell (INSERM UMR 1163 – Institut Imagine), Frédéric Rieux-Laucat (INSERM UMR 1163 – Institut Imagine), Lars Rogge (Institut Pasteur), Anavaj Sakuntabhai (Institut Pasteur), Olivier Schwartz (Institut Pasteur), Benno Schwikowski (Institut Pasteur), Spencer Shorte (Institut Pasteur), Frédéric Tangy (Institut Pasteur), Antoine Toubert (Hôpital Saint-Louis), Mathilde Touvier (Université Paris 13), Marie-Noëlle Ungeheuer (Institut Pasteur), Christophe Zimmer (Institut Pasteur), Matthew L. Albert (Insitro)§, Darragh Duffy (Institut Pasteur)§, Lluis Quintana-Murci (Institut Pasteur)§. § co-coordinators of the Milieu Intérieur Consortium., PATIN, Etienne, Laboratoires d'excellence - GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE - - MILIEU INTERIEUR2010 - ANR-10-LABX-0069 - LABX - VALID, Instituts Hospitalo-Universitaires - Institut Hospitalo-Universitaire Imagine - - Imagine2010 - ANR-10-IAHU-0001 - IAHU - VALID, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)

المصدر: Genome Medicine
Genome Medicine, 2022, 14 (1), pp.28. ⟨10.1186/s13073-022-01032-y⟩

مصطلحات موضوعية: medicine.medical_treatment, Health Status, Primary Immunodeficiency Diseases, Quantitative Trait Loci, immune variability, Quantitative trait locus, Biology, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, Polymorphism, Single Nucleotide, Blood cell, 03 medical and health sciences, 0302 clinical medicine, Immune system, immune cells, Genetics, medicine, Humans, Receptor, Molecular Biology, Genetics (clinical), 030304 developmental biology, Genetic association, 2. Zero hunger, 0303 health sciences, pQTL, Blood Proteins, medicine.disease, Blood proteins, 3. Good health, Cytokine, medicine.anatomical_structure, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, 030220 oncology & carcinogenesis, Immunology, Primary immunodeficiency, Molecular Medicine, [SDV.IMM]Life Sciences [q-bio]/Immunology, plasma proteins, Genome-Wide Association Study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1723e6d253b7b5ce9a43d2762feae6Test
https://pubmed.ncbi.nlm.nih.gov/35264221Test

المؤلفون: Françoise Dromer, Antonio Rausell, Elizabeth Filander, Bruno Charbit, Odile Gelpi, Kalla Astrom, Stanislas Pol, Elisa Nemes, Vincent Rouilly, Mark Hatherill, Hadn Africa, Humphrey Mulenga, Ana Cumano, Hugo Mouquet, Etienne Patin, Lluis Quintana-Murci, Lungisa Jaxa, Laurent Abel, Milena Hasan, James P. Di Santo, Claude Leclerc, Spencer L. Shorte, Vassili Soumelis, Stéphanie Thomas, Caroline Demangel, Mathilde Touvier, Andrés Alcover, Thomas J. Scriba, Matthew L. Albert, Anavaj Sakuntabhai, Hugues Aschard, Nikaïa Smith, Serge Hercberg, Darragh Duffy, Jost Enninga, Olivier Schwartz, Ivo Gomperts-Boneca, Marie-Noëlle Ungeheuer, Simbarashe Mabwe, Ludovic Deriano, Frédéric Tangy, Gérard Eberl, Sandra Pellegrini, Antoine Toubert, Lars Rogge, Stephanus T. Malherbe, Gerhard Walzl, Michele Tameris, Munyaradzi Musvosvi, Alba Llibre, Benno Schwikowski, Olivier Lantz, Nicole Bilek, Philippe Bousso, Pierre Bruhns, Jacques Fellay, Eric Tartour

المصدر: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), Tuberculosis, Enzyme-Linked Immunosorbent Assay, Disease, Asymptomatic, QuantiFERON, Mycobacterium tuberculosis, Interferon-gamma, 03 medical and health sciences, 0302 clinical medicine, Antigen, Latent Tuberculosis, medicine, Humans, 030212 general & internal medicine, Online only Articles, Whole blood, biology, business.industry, immune profiling, biomarkers, patient stratification, bacterial infections and mycoses, medicine.disease, biology.organism_classification, cytokines, 3. Good health, AcademicSubjects/MED00290, 030104 developmental biology, Infectious Diseases, Cohort, Immunology, medicine.symptom, business, Interferon-gamma Release Tests

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973c9681e36288da04877fa23cf1cb9cTest
https://doi.org/10.1093/cid/ciaa1562Test

المؤلفون: Christian Hammer, Lluis Quintana-Murci, Allyson L. Byrd, Jacques Fellay, Cécile Alanio, Petar Scepanovic, Valentin Partula, Mathilde Touvier, Olivier Lantz, Stanislas Mondot, Jacob Bergstedt, Etienne Patin, Darragh Duffy, Matthew L. Albert, Flavia Hodel

المساهمون: Ecole Polytechnique Fédérale de Lausanne (EPFL), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Genentech, Inc. [San Francisco], Perelman School of Medicine, University of Pennsylvania [Philadelphia], Lund University [Lund], Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunobiologie des Cellules dendritiques, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Swiss Institute of Bioinformatics [Genève] (SIB), Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), This work benefited from the support of the French government’s Invest in the Future Program, managed by the Agence Nationale de la Recherche (ANR, reference 10-LABX-69-01). It was also supported by a grant from the Swiss National Science Foundation (31003A_175603 to JF)., We would like to thank to all the donors for their contribution to the study. The Milieu Intérieur Consortium is composed of the following team leaders: Laurent Abel (Hôpital Necker, Paris, France), Andres Alcover (Institut Pasteur, Paris, France), Hugues Aschard (Institut Pasteur, Paris, France), Kalla Astrom (Lund University, Lund, Sweden), Philippe Bousso (Institut Pasteur, Paris, France), Pierre Bruhns (Institut Pasteur, Paris, France), Ana Cumano (Institut Pasteur, Paris, France), Caroline Demangel (Institut Pasteur, Paris, France), Ludovic Deriano (Institut Pasteur, Paris, France), James Di Santo (Institut Pasteur, Paris, France), Françoise Dromer (Institut Pasteur, Paris, France), Darragh Duffy (Institut Pasteur, Paris, France), Gérard Eberl (Institut Pasteur, Paris, France), Jost Enninga (Institut Pasteur, Paris, France), Jacques Fellay (EPFL, Lausanne, Switzerland), Odile Gelpi (Institut Pasteur, Paris, France), Ivo Gomperts-Boneca (Institut Pasteur, Paris, France), Milena Hasan (Institut Pasteur, Paris, France), Serge Hercberg (Université Paris 13, Paris, France), Olivier Lantz (Institut Curie, Paris, France), Claude Leclerc (Institut Pasteur, Paris, France), Hugo Mouquet (Institut Pasteur, Paris, France), Sandra Pellegrini (Institut Pasteur, Paris, France), Stanislas Pol (Hôpital Côchin, Paris, France), Antonio Rausell (INSERM UMR 1163 – Institut Imagine, Paris, France), Lars Rogge (Institut Pasteur, Paris, France), Anavaj Sakuntabhai (Institut Pasteur, Paris, France), Olivier Schwartz (Institut Pasteur, Paris, France), Benno Schwikowski (Institut Pasteur, Paris, France), Spencer Shorte (Institut Pasteur, Paris, France), Vassili Soumelis (Institut Curie, Paris, France), Frédéric Tangy (Institut Pasteur, Paris, France), Eric Tartour (Hôpital Européen George Pompidou, Paris, France), Antoine Toubert (Hôpital Saint-Louis, Paris, France), Mathilde Touvier (Université Paris 13, Paris, France), Marie-Noëlle Ungeheuer (Institut Pasteur, Paris, France), Matthew L. Albert (Roche Genentech, South San Francisco, CA, USA), and Lluis Quintana-Murci (Institut Pasteur, Paris, France). Matthew L. Albert and Lluis Quintana-Murci are the co-coordinators of the consortium. Additional information can be found at http://www.milieuinterieur.fr/enTest., ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Vougny, Marie-Christine, Laboratoires d'excellence - GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE - - MILIEU INTERIEUR2010 - ANR-10-LABX-0069 - LABX - VALID, Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Pennsylvania, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Collège de France - Chaire Génomique humaine et évolution, Collège de France (CdF (institution)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Institut Curie-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR: 10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Fellay, Jacques [0000-0002-8240-939X], Apollo - University of Cambridge Repository, Fellay, Jacques

المصدر: Microbiome
Microbiome, BioMed Central, 2019, 7 (1), pp.130. ⟨10.1186/s40168-019-0747-x⟩
Microbiome, Vol 7, Iss 1, Pp 1-15 (2019)
Microbiome, 2019, 7 (1), pp.130. ⟨10.1186/s40168-019-0747-x⟩
Microbiome 1 (7), . (2019)

مصطلحات موضوعية: Male, population-structure, imputation, Genome-wide association study, dna, Cohort Studies, Feces, 0302 clinical medicine, GWAS, Gut, 16S rRNA gene sequencing, media_common, milieu-interieur, 0303 health sciences, dynamics, Genomics, Middle Aged, Healthy Volunteers, 3. Good health, 030220 oncology & carcinogenesis, Cohort, Medical genetics, lcsh:QR100-130, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Demographics, Sex ratio, Human, Adult, Microbiology (medical), medicine.medical_specialty, [SDV.IMM] Life Sciences [q-bio]/Immunology, media_common.quotation_subject, Single-nucleotide polymorphism, Biology, Environment, Microbiology, lcsh:Microbial ecology, Young Adult, 03 medical and health sciences, Genetic variation, medicine, Humans, Microbiome, genome, Life Style, Aged, Demography, 030304 developmental biology, inference, Healthy, Bacteria, Host (biology), Research, Gastrointestinal Microbiome, extraction, 030217 neurology & neurosurgery, Imputation (genetics), Diversity (politics)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190ce190808b5871ffb4a155b85d25a5Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-02307232/file/document.pdfTest

المؤلفون: Elisa Desmetz, Lluis Quintana-Murci, Mathilde Touvier, Léopold Fezeu, Serge Hercberg, Nathalie Druesne-Pecollo, Chantal Julia, Darragh Duffy, Pilar Galan, Mélanie Deschasaux, Paule Latino-Martel, Valentin Partula, Olivier Lantz, Bernard Srour, Stanislas Mondot, Emmanuelle Kesse-Guyot, Eloi Chazelas, Matthew L. Albert

المساهمون: Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris Cité (UPCité), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Immunité et cancer (U932), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC1428 IGR-CURIE, Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Chaire Génomique humaine et évolution, Collège de France (CdF (institution)), Department of Immunology and Infectious Diseases, Insitro [San Francisco], Immunobiologie des Cellules dendritiques, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), NutriNet-Santé study was supported by the following French public institutions: Ministère de la Santé, Santé Publique France, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA), Conservatoire National des Arts et Métiers (CNAM) and Université Paris-XIII Nord. The Milieu Intérieur Consortium was supported by French Government’s Investissement d’Avenir Program, Laboratoire d’Excellence 'Milieu Intérieur' Grant ANR-10-LABX-69-01. Valentin Partula was funded by Ph.D. a grant from the Labex Milieu Interieur, and is provided financial support from École doctorale 474 Frontières de l’Innovation en Recherche et Education – Programme Bettencourt., Milieu intérieur, ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Collège de France - Chaire Génomique humaine et évolution, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Curie [Paris]

المصدر: The American Journal of Clinical Nutrition
The American Journal of Clinical Nutrition, Oxford University Press, 2020, ⟨10.1093/ajcn/nqaa063⟩
The American Journal of Clinical Nutrition, 2020, ⟨10.1093/ajcn/nqaa063⟩
American Journal of Clinical Nutrition
American Journal of Clinical Nutrition, American Society for Nutrition, 2020, ⟨10.1093/ajcn/nqaa063⟩

مصطلحات موضوعية: Adult, Dietary Fiber, Male, medicine.medical_specialty, Colorectal cancer, prospective cohort, Medicine (miscellaneous), 030209 endocrinology & metabolism, Type 2 diabetes, dietary fibers, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Neoplasms, Internal medicine, Vegetables, cancers, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, 2. Zero hunger, Nutrition and Dietetics, Proportional hazards model, business.industry, Public health, Cancer, Middle Aged, medicine.disease, mortality, cardiovascular diseases, 3. Good health, Diabetes Mellitus, Type 2, Fruit, Cohort, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, type 2 diabetes, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b5ab88d73b3767ca0ca25219a88c18Test
https://doi.org/10.1093/ajcn/nqaa063Test

المؤلفون: Christian Hammer, Sergio Ley Acosta, Matthew L. Albert, Julie Hunkapiller, J. D. Carroll, Chandler Gs, Tushar Bhangale, Ira Mellman, Di Nucci F, Zia Khan, Mark I McCarthy, Maiya

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, endocrine system, endocrine system diseases, Science, General Physics and Astronomy, Genome-wide association study, Autoimmunity, Triple Negative Breast Neoplasms, Kaplan-Meier Estimate, Lower risk, Antibodies, Monoclonal, Humanized, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Immune system, Hypothyroidism, Meta-Analysis as Topic, Atezolizumab, Internal medicine, Genetic variation, medicine, Genetics, Humans, Adverse effect, Cancer genetics, Immune Checkpoint Inhibitors, Triple-negative breast cancer, Retrospective Studies, Multidisciplinary, business.industry, Cancer, Genetic Variation, General Chemistry, medicine.disease, Thyroid Diseases, Blockade, 030104 developmental biology, Risk factors, 030220 oncology & carcinogenesis, Immunology, Thyroid autoimmunity, Female, Immunotherapy, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f68077b105fa838ab15c65a5b902caaTest
http://europepmc.org/articles/PMC8184890Test

المؤلفون: Oliver J. Harrison, Lluis Quintana-Murci, Allyson L. Byrd, Darragh Duffy, Deepti R. Nagarkar, Jacob Bergstedt, Etienne Patin, Menghan Liu, Matthew L. Albert, Bruno Charbit, Kei E. Fujimura, Ira Mellman, Svetlana Lyalina

المساهمون: Genentech, Inc. [San Francisco], New York University School of Medicine, NYU System (NYU), Cytometrie et Biomarqueurs – Cytometry and Biomarkers (UTechS CB), Institut Pasteur [Paris], Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Benaroya Research Institute [Seattle] (BRI), Chaire Génomique humaine et évolution, Collège de France (CdF (institution)), Immunologie Translationnelle - Translational Immunology lab, Insitro [San Francisco], This work benefited from support of the French government’s Invest in the Future program. This program is managed by the Agence Nationale de la Recherche, reference ANR-10-LABX-69-01., We thank all the donors for their participation in the study. We thank J. Segre and F. Tamburini for critical reading of the manuscript and helpful comments. We also thank J. Paulson and O. Mayba for expert statistical support., The Milieu Intérieur Consortium is composed of the following team leaders: Laurent Abel, Andres Alcover, Hugues Aschard, Kalla Astrom, Philippe Bousso, Pierre Bruhns, Ana Cumano, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Serge Hercberg, Olivier Lantz, Hugo Mouquet, Etienne Patin, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Darragh Duffy, Matthew L. Albert, and Lluis Quintana-Murci., ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Collège de France - Chaire Génomique humaine et évolution

المصدر: The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 218 (1), ⟨10.1084/jem.20200606⟩
Journal of Experimental Medicine, 2020, 218 (1), ⟨10.1084/jem.20200606⟩

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Immunology, Host factors, Disease, Technical Advances and Resources, Infectious Disease and Host Defense, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Immunology and Allergy, Humans, Microbiome, Bifidobacterium, Aged, biology, Mucosal Immunology, Middle Aged, biology.organism_classification, Biological sex, Gut microbiome, 3. Good health, Gastrointestinal Microbiome, 030104 developmental biology, Community composition, Cohort, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde688bac0c2638c883890db8f9b2b3bTest
https://pubmed.ncbi.nlm.nih.gov/33175106Test

المؤلفون: Audrey Chansard, Nelly Dubrulle, Mathilde Poujol de Molliens, Pierre B. Falanga, Tharshana Stephen, Milena Hasan, Ger van Zandbergen, Nathalie Aulner, Spencer L. Shorte, Brigitte David-Watine, the Milieu Intérieur Consortium, Laurent Abel, Andres Alcover, Hugues Aschard, Kalla Astrom, Philippe Bousso, Pierre Bruhns, Ana Cumano, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Serge Hercberg, Olivier Lantz, Hugo Mouquet, Etienne Patin, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Trouvier, Marie-Noëlle Ungeheuer, Darragh Duffy, Matthew L. Albert, Lluis Quintana-Murci

المساهمون: BioImagerie Photonique – Photonic BioImaging (UTechS PBI), Institut Pasteur [Paris], Cytometrie et Biomarqueurs – Cytometry and Biomarkers (UTechS CB), Paul-Ehrlich-Institute - Federal Institute for Vaccines and Biomedicines (EPI), Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Frontiers in Immunology, Vol 11 (2021)
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in immunology, 12:685768
Frontiers in Immunology, Frontiers, 2021, 12, pp.685768. ⟨10.3389/fimmu.2021.685768⟩
Frontiers in immunology, 11:569331
Frontiers in Immunology, 2021, 12, pp.685768. ⟨10.3389/fimmu.2021.685768⟩

مصطلحات موضوعية: Lipopolysaccharides, 0301 basic medicine, Cell, Gene Expression, Herpesvirus 1, Human, immortalization, NF-κB, 0302 clinical medicine, TLR (Toll like receptors), FACS, innate immunity, human primary cells, HSV-1, cytokines, Angeborene Immunität, Genes, Reporter, Immunology and Allergy, Polylysine, NF-kB, ComputingMilieux_MISCELLANEOUS, Cells, Cultured, Original Research, education.field_of_study, Middle Aged, Flow Cytometry, medicine.anatomical_structure, Host-Pathogen Interactions, [SDV.IMM]Life Sciences [q-bio]/Immunology, Biological Assay, Female, Cell activation, Population, Immunology, Context (language use), Computational biology, Biology, Cell Line, 03 medical and health sciences, Immune system, medicine, Humans, education, Fibroblast, Innate immune system, Correction, Fibroblasts, RC581-607, Immunity, Innate, Toll-Like Receptor 3, Toll-Like Receptor 4, Poly I-C, 030104 developmental biology, Biological Variation, Population, TLR3, Immunologic diseases. Allergy, 030217 neurology & neurosurgery, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de994326dc93ea27817eb42fd1ab1d1cTest

المؤلفون: Armanda Casrouge, Alessandro Aiuti, Silvia Sánchez-Ramón, A V Sauer, Matthew L. Albert, Marta Tejera-Alhambra, R Barreira da Silva, ICAReB, Molly A. Ingersoll, C Cancrini

المساهمون: Immunobiologie des Cellules dendritiques, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], IRCCS San Raffaele Scientific Institute [Milan, Italie], Genentech, Inc. [San Francisco], Hospital General Universitario 'Gregorio Marañón' [Madrid], Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources (ICAReB), Institut Pasteur [Paris], IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Università degli Studi di Roma Tor Vergata [Roma], Funding was provided by the Institut Pasteur (Pasteur‐Roux post‐doctoral fellowship to R. B. S.), the Ligue Contre le Cancer (M. L. A.), the Fondation ARC pour la recherche sur le cancer (M. L. A.), the Italian Ministero della Salute (GR‐2011‐02346985 to A. V. S.), the European Union Seventh Framework Programme Marie Curie Action (PCIG11‐GA‐2012‐3221170 to M. A. I.) and the French government's Invest in the Future Program, managed by the Agence Nationale de la Recherche (LabEx Immuno‐Onco to A. C., R. B. d. S., M. A. I. and M. L. A.)., The authors thank the numerous patients and healthy volunteers who kindly donated peripheral blood for these experiments. We thank Immacolata Brigida for data management and H. Saklani for providing tetramers. We thank James Di Santo and Darragh Duffy for critical reading of the manuscript. We would like to acknowledge Marie‐Noelle Unheheuer for her role in leadership of the Clinical Investigation and Access to BioResources platform (ICAReB)., ANR-11-IDEX-0005,USPC,Université Sorbonne Paris Cité(2011), European Project: 3221170,European Union Seventh Framework Programme Marie Curie Action, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)

المصدر: Clinical & Experimental Immunology
Clinical and Experimental Immunology
Clinical and Experimental Immunology, Wiley, 2018, 194 (2), pp.166-179. ⟨10.1111/cei.13163⟩
Clinical and Experimental Immunology, 2018, 194 (2), pp.166-179. ⟨10.1111/cei.13163⟩

مصطلحات موضوعية: 0301 basic medicine, Chemokine, Bodily Secretions, Lymphocyte, T cell, Dipeptidyl Peptidase 4, T-Lymphocytes, Immunology, T cells, chemokines, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, Orthomyxoviridae Infections, medicine, Immunology and Allergy, Animals, Humans, Dipeptidyl peptidase-4, Mice, Knockout, Transplantation Chimera, biology, Chemistry, Membrane Proteins, Original Articles, 3. Good health, Hematopoiesis, Mice, Inbred C57BL, immunodeficiency diseases, Haematopoiesis, Disease Models, Animal, Settore MED/02, 030104 developmental biology, medicine.anatomical_structure, Solubility, Influenza A virus, 030220 oncology & carcinogenesis, biology.protein, [SDV.IMM]Life Sciences [q-bio]/Immunology, Severe Combined Immunodeficiency, Bone marrow, CD8, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fe8ed5c03675e8b96fc1b529021da2Test

المؤلفون: Valentin, Partula, Mélanie, Deschasaux-Tanguy, Stanislas, Mondot, Agnès, Victor-Bala, Nadia, Bouchemal, Lucie, Lécuyer, Christine, Bobin-Dubigeon, Marion J, Torres, Emmanuelle, Kesse-Guyot, Bruno, Charbit, Etienne, Patin, Karen E, Assmann, Paule, Latino-Martel, Chantal, Julia, Pilar, Galan, Serge, Hercberg, Lluis, Quintana-Murci, Matthew L, Albert, Darragh, Duffy, Olivier, Lantz, Philippe, Savarin, Mohamed Nawfal, Triba, Mathilde, Touvier

المصدر: The British journal of nutrition. 126(7)

مصطلحات موضوعية: Adult, Feces, Plasma, Creatinine, RNA, Ribosomal, 16S, Metabolome, Humans, Metabolomics, Gastrointestinal Microbiome

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::7ecaeb29195e068a2cd67e2b1f0f35c0Test
https://pubmed.ncbi.nlm.nih.gov/33298217Test