دورية أكاديمية
Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero
| العنوان: | Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero |
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| المؤلفون: | Nilsen, Guro Ørndal, Simpson, Melanie Rae, Hanem, Liv Guro Engen, Løvvik, Tone Shetelig, Ødegård, Rønnaug, Stokkeland, Live Marie T, Andersen, Marianne Skovsager, Juliusson, Petur Benedikt, Vanky, Eszter |
| المصدر: | Nilsen , G Ø , Simpson , M R , Hanem , L G E , Løvvik , T S , Ødegård , R , Stokkeland , L M T , Andersen , M S , Juliusson , P B & Vanky , E 2024 , ' Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero ' , Acta Obstetricia et Gynecologica Scandinavica , vol. 103 , no. 1 , pp. 176-187 . https://doi.org/10.1111/aogs.14637Test |
| سنة النشر: | 2024 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | anthropometry, birth length, birthweight, head circumference, metformin, polycystic ovary syndrome, pregnancy, prenatal exposure, Humans, Androgens/therapeutic use, Randomized Controlled Trials as Topic, Birth Weight, Metformin/therapeutic use, Placenta, Female, Polycystic Ovary Syndrome/drug therapy, Infant, Newborn |
| الوصف: | INTRODUCTION: Fetal growth may be affected by both maternal polycystic ovary syndrome (PCOS) and metformin therapy. Here, we explore the effect of intrauterine metformin exposure on birth anthropometrics of infants born to women with PCOS. We also investigated whether the effect of metformin on birth anthropometrics is modified by maternal pre-pregnancy body mass index, PCOS hyperandrogenic phenotype, serum androgen levels, preconception use of metformin and offspring sex. Additionally, we assessed newborn anthropometrics in relation to a national reference population. MATERIAL AND METHODS: Individual data from three randomized controlled triasl were pooled. The randomized controlled trials investigated the effects of metformin in pregnant women with PCOS. In all, 397 and 403 were randomized to the metformin and placebo groups, respectively. A Scandinavian growth reference was used to calculate sex and gestational age adjusted z-scores. Linear regression models were used to estimate the effect of metformin on offspring z-scores of head circumference, birth length, birthweight, placental weight, body mass index, ponderal index and birthweight:placental weight ratio. S-testosterone, s-androstenedione, and s-sex-hormone binding globulin from four timepoints in pregnancy were analyzed. RESULTS: Compared with the PCOS-placebo group, newborns in the PCOS-metformin group had larger head circumference (head circumference z-score: mean difference = 0.25, 95% CI = 0.11- 0.40). This effect of metformin on head circumference z-score was particularly observed among offspring of overweight/obese mothers and mothers with hyperandrogenic PCOS-phenotype. We observed no difference in other anthropometric measures between the metformin and placebo groups or any clear interaction between maternal androgen levels and metformin. Newborns in the PCOS-placebo group were shorter than in the reference population (birth length z-score: mean = -0.04, 95% CI = -0.05 to -0.03), but head circumference and birthweight were similar. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/e242136b-6317-4794-822b-650f78433797Test |
| DOI: | 10.1111/aogs.14637 |
| الإتاحة: | https://doi.org/10.1111/aogs.14637Test https://portal.findresearcher.sdu.dk/da/publications/e242136b-6317-4794-822b-650f78433797Test https://findresearcher.sdu.dk/ws/files/252584588/Acta_Obstet_Gynecol_Scand_-_2023_-_Nilsen_-_Anthropometrics_of_neonates_born_to_mothers_with_PCOS_with_metformin_or_placebo.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.72C1D15B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/aogs.14637 |
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