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المؤلفون: Shabih Shakeel, Christopher J. Russo, Gianluca Degliesposti, Pablo Alcón, Eeson Rajendra, J.M. Skehel, Ketan J. Patel, Sarah L. Maslen, Carol V. Robinson, Chris H. Hill, Dror S. Chorev, Francis J. O’Reilly, Juri Rappsilber, Shaoda He, Sjors H.W. Scheres, Lori A. Passmore
المصدر: Shakeel, S, Rajendral, E, Alcón, P, O’Reilly, F J, Chorev, D S, Maslen, S, Degliesposti, G, Russo, C J, He, S, Hill, C H, Skehel, J M, Scheres, S H W, Patel, K J, Rappsilber, J, Robinson, C V & Passmore, L A 2019, ' Structure of the fanconi anaemia monoubiquitin ligase complex ', Nature, vol. 575, pp. 234-237 . https://doi.org/10.1038/s41586-019-1703-4Test
Natureمصطلحات موضوعية: Models, Molecular, Protein subunit, Fanconi Anemia Complementation Group L Protein, medicine.disease_cause, Article, Mass Spectrometry, Ligases, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, FANCD2, Ring finger, medicine, Humans, Animals, FANCL, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, DNA ligase, Mutation, Multidisciplinary, biology, Fanconi Anemia Complementation Group D2 Protein, Cryoelectron Microscopy, Ubiquitination, Fanconi Anemia Complementation Group Proteins, Ubiquitin ligase, Cell biology, FANCB, Protein Subunits, Fanconi Anemia, medicine.anatomical_structure, chemistry, Multiprotein Complexes, biology.protein, Protein Multimerization, Chickens, 030217 neurology & neurosurgery
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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bffaa0a6d75638ea3668a8eca98bf3Test
https://doi.org/10.1038/s41586-019-1703-4Test -
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المؤلفون: Olga V. Kochenova, Justin L. Sparks, Meng Wang, Lin Deng, Johannes C. Walter, Michael R. G. Hodskinson, Daniel R. Semlow, Ravindra Amunugama, Gheorghe Chistol, Claudia A. Mimoso, Emily Low, R. Alex Wu, Ketan J. Patel, Ashley N. Kamimae-Lanning
المصدر: Nature
مصطلحات موضوعية: DNA Replication, DNA Repair, DNA repair, Ubiquitin-Protein Ligases, Xenopus, macromolecular substances, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Animals, Humans, N-Glycosyl Hydrolases, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, Ubiquitin, Chemistry, technology, industry, and agriculture, DNA Helicases, Ubiquitination, DNA replication, Helicase, DNA, Minichromosome Maintenance Complex Component 7, GINS, Ubiquitin ligase, Cell biology, DNA glycosylase, biology.protein, Replisome, Female, 030217 neurology & neurosurgery, Protein Binding
وصف الملف: application/pdf; image/jpeg
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7999320f7690bda56182d186dfb54b8Test
https://doi.org/10.1038/s41586-019-1002-0Test -
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المؤلفون: Andreas C. Joerger, Bradley Springett, Alan R. Fersht, Felix A. Dingler, Lorena Verduci, Matthias R. Bauer, Ketan J. Patel, Rhiannon N. Jones, John Spencer, Raysa Khan Tareque
المصدر: Future Medicinal Chemistry
Future Med Chemمصطلحات موضوعية: Transcriptional Activation, p53, Mutant, Cancer therapy, Carbazoles, protein stabilization, medicine.disease_cause, DNA-binding protein, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Tumor Cells, Cultured, Humans, RM0260, Cancer mutations, 030304 developmental biology, RM0300, Pharmacology, 0303 health sciences, Mutation, Transcriptional activity, Molecular Structure, cancer mutations, Chemistry, molecular chaperones, Cancer, medicine.disease, Cell biology, 030220 oncology & carcinogenesis, Molecular Medicine, cancer therapy, structure-based drug design, Protein stabilization, Tumor Suppressor Protein p53, Erratum, tumor suppression, CRISPR/Cas9 p53 knockout, Research Article
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6730cd1f62e5fc2066d75c60511b9fTest
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المؤلفون: D. Horil Roy, Alan R. Fersht, Matthias G. J. Baud, Andreas C. Joerger, Matthias R. Bauer, Ketan J. Patel, Felix A. Dingler, L. Verduci
المصدر: European Journal of Medicinal Chemistry
مصطلحات موضوعية: 0301 basic medicine, Cell cycle checkpoint, Cell Survival, Mutant, Antineoplastic Agents, Real-Time Polymerase Chain Reaction, Article, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Puma, Drug Discovery, Tumor Cells, Cultured, Humans, ddc:610, Benzothiazoles, Thermolabile, Cell Proliferation, Pharmacology, BTG2, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Anticancer therapy, General Medicine, biology.organism_classification, Small molecule, 3. Good health, Cell biology, Structure-based drug discovery, 030104 developmental biology, Apoptosis, Cell culture, Mutant p53, 030220 oncology & carcinogenesis, Drug Screening Assays, Antitumor, Tumor Suppressor Protein p53, Signal Transduction
وصف الملف: application/octet-stream; text
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9c94e4d5285fe5ab37566b73ee9eecTest
http://europepmc.org/articles/PMC5986712Test -
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المؤلفون: Etsuro Ito, Seiji Kojima, Kenichi Yoshida, Rui Yu, Camille Nadler, Paul S. Monks, Asuka Hira, Nicola K. Wilson, Motohiro Kato, Ashley N. Kamimae-Lanning, Satoru Miyano, Hiromasa Yabe, Tomoo Osumi, Minako Mori, Miharu Yabe, Michael R. G. Hodskinson, Minoru Takata, Hideki Muramatsu, Lucas B. Pontel, Seishi Ogawa, Toshinori Moriguchi, Christopher L. Millington, Yusuke Okamoto, Masayuki Kobayashi, Yuichi Shiraishi, Meng Wang, Ketan J. Patel, Frederic Langevin, Berthold Göttgens, Yusuke Okuno, Sam Watcham, Felix A. Dingler, Rebecca Cordell, Keitaro Matsuo, Nina Oberbeck, Anfeng Mu
المساهمون: Wilson, Nicola [0000-0003-0865-7333], Gottgens, Berthold [0000-0001-6302-5705], Apollo - University of Cambridge Repository
المصدر: Molecular Cell
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICETمصطلحات موضوعية: Male, DNA Repair, Somatic cell, medicine.disease_cause, Substrate Specificity, purl.org/becyt/ford/1 [https], DNA Adducts, Mice, 0302 clinical medicine, Child, IMMUNODEFICIENCY, 0303 health sciences, Mutation, Leukemia, Aldehyde Dehydrogenase, Mitochondrial, CANCER, Cell biology, Child, Preschool, Female, Stem cell, mutagenesis, Adolescent, DNA repair, DNA damage, AGEING, Biology, HEMATOPOIESIS, DNA DAMAGE, Article, 03 medical and health sciences, medicine, Animals, Humans, cancer, FORMALDEHYDE, HEMATOPOIETIC STEM CELLS, purl.org/becyt/ford/1.6 [https], Molecular Biology, 030304 developmental biology, ALDH2, Aldehydes, MUTAGENESIS, Mutagenesis, Alcohol Dehydrogenase, Infant, ONCOMETABOLITE, Cell Biology, medicine.disease, oncometabolite, hematopoiesis, hematopoietic stem cells, BONE MARROW FAILURE, ageing, formaldehyde, bone marrow failure, immunodeficiency, 030217 neurology & neurosurgery
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d65d6f96b03ddf58df2484332f40f7Test
http://hdl.handle.net/2433/255881Test -
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المؤلفون: Johannes Meiser, Lucas B. Pontel, Guillermo Burgos-Barragan, Felix A. Dingler, Christopher J. Chang, Ketan J. Patel, Alexei Vazquez, Matthias Pietzke, Niek Wit, Thomas F. Brewer, Lee Mulderrig, Paul S. Monks, Rebecca Cordell, Iván V. Rosado
المساهمون: CRUK Cambridge Centre, Wellcome Trust, Children With Cancer UK, European Commission, Ministerio de Economía y Competitividad (España), National Institutes of Health (US), Howard Hughes Medical Institute, Engineering and Physical Sciences Research Council (UK), German Research Foundation, Medical Research Council (UK)
المصدر: Nature, vol 548, iss 7669
Burgos-Barragan, G; Wit, N; Meiser, J; Dingler, FA; Pietzke, M; Mulderrig, L; et al.(2017). Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism. Nature, 548(7669), 549-554. doi: 10.1038/nature23481. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/3dg2v89sTest
Digital.CSIC. Repositorio Institucional del CSIC
instnameمصطلحات موضوعية: 0301 basic medicine, Genome instability, DNA Repair, Coenzymes, 01 natural sciences, Inactivation, Serine, Mice, health care economics and organizations, Tetrahydrofolates, chemistry.chemical_classification, Multidisciplinary, biology, Nucleotides, ADH5, Amino acid, Cross-Linking Reagents, Biochemistry, Inactivation, Metabolic, Oxidation-Reduction, CIENCIAS NATURALES Y EXACTAS, Metabolic Networks and Pathways, DNA repair, DNA damage, General Science & Technology, Otras Ciencias Biológicas, 010402 general chemistry, Article, Cell Line, Ciencias Biológicas, 03 medical and health sciences, Folic Acid, Complementary and Alternative Medicine, Formaldehyde, Complementary and Integrative Health, Genetics, Animals, Humans, Alcohol dehydrogenase, 1C CYCLE, Alcohol Dehydrogenase, Metabolism, DNA Crosslinking Agent, Carbon, 0104 chemical sciences, 030104 developmental biology, FANCONI ANEMIA, chemistry, biology.protein, Metabolic, Generic health relevance, Chickens, DNA Damage, Mutagens
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b6f34354fba3910da3c7fcb5849b92Test
https://escholarship.org/uc/item/3dg2v89sTest -
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المؤلفون: Ketan J. Patel, Lori A. Passmore, Juan I. Garaycoechea, Eeson Rajendra
المصدر: Nucleic Acids Research
مصطلحات موضوعية: Genome instability, DNA repair, Ataxia Telangiectasia Mutated Proteins, Biology, Genome Integrity, Repair and Replication, Cell Line, chemistry.chemical_compound, Fanconi anemia, Chromosome instability, Genetics, RUVBL2, medicine, Animals, Humans, Gene, Adenosine Triphosphatases, Mice, Knockout, DNA Helicases, Anemia, Aplastic, DNA Repair Pathway, medicine.disease, Hematopoietic Stem Cells, Molecular biology, Fanconi Anemia Complementation Group Proteins, Cross-Linking Reagents, chemistry, ATPases Associated with Diverse Cellular Activities, Carrier Proteins, Chickens, DNA, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56df4227f8207ef12c9891eba9152625Test
http://europepmc.org/articles/PMC4267650Test -
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المؤلفون: Lucas B. Pontel, Christopher J. Chang, Niek Wit, Thomas F. Brewer, Guillermo Burgos-Barragan, Ketan J. Patel, Kevin J. Bruemmer, Ryan R. Walvoord
المصدر: Bruemmer, KJ; Walvoord, RR; Brewer, TF; Burgos-Barragan, G; Wit, N; Pontel, LB; et al.(2017). Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells. Journal of the American Chemical Society, 139(15), 5338-5350. doi: 10.1021/jacs.6b12460. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/8tj5s7r7Test
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of the American Chemical Society, vol 139, iss 15
Journal of the American Chemical Societyمصطلحات موضوعية: Fluorescence-lifetime imaging microscopy, Fluorophore, Cell Survival, Otras Ciencias Biológicas, Context (language use), Computational biology, 010402 general chemistry, 01 natural sciences, Biochemistry, Article, Catalysis, purl.org/becyt/ford/1 [https], Biological pathway, Ciencias Biológicas, chemistry.chemical_compound, Colloid and Surface Chemistry, AZA-COPE REACTION, Formaldehyde, Humans, FORMALDEHYDE, Epigenetics, purl.org/becyt/ford/1.6 [https], Cope reaction, Aza Compounds, Molecular Structure, 010405 organic chemistry, Chemistry, Prevention, Optical Imaging, General Chemistry, Limiting, ENDOGENOUS, 0104 chemical sciences, HEK293 Cells, Chemical Sciences, CELLS, CIENCIAS NATURALES Y EXACTAS
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24371b4e75a3f7454d65fdbd7b34f50Test
https://pubs.acs.org/doi/abs/10.1021/jacs.6b12460Test -
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المؤلفون: Meng Wang, Gillian L. Dornan, Vibe H. Oestergaard, Ketan J. Patel, Eeson Rajendra, Lori A. Passmore, Frederic Langevin
المصدر: Molecular Cell
Rajendra, E, Østergaard, V H, Langevin, F, Wang, M, Dornan, G L, Patel, K J & Passmore, L A 2014, ' The genetic and biochemical basis of FANCD2 Monoubiquitination ', Molecular Cell, vol. 54, no. 5, pp. 858-869 . https://doi.org/10.1016Test/j.molcel.2014.05.001مصطلحات موضوعية: Protein subunit, Fanconi Anemia Complementation Group L Protein, macromolecular substances, Article, Cell Line, Avian Proteins, Ubiquitin, hemic and lymphatic diseases, FANCD2, Monoubiquitination, Animals, Humans, FANCL, Molecular Biology, biology, Fanconi Anemia Complementation Group D2 Protein, Ubiquitination, Cell Biology, DNA Repair Pathway, Fanconi Anemia Complementation Group Proteins, 3. Good health, Ubiquitin ligase, FANCB, Fanconi Anemia, Biochemistry, biology.protein, Ubiquitin-Specific Proteases, Chickens
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc897ac6045bb202e976d341868da36aTest
http://europepmc.org/articles/PMC4051986Test -
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المؤلفون: Lara G. Phillips, Peter Sarkies, Julian E. Sale, Shankar Balasubramanian, Ketan J. Patel, Pierre Murat
المصدر: Nucleic Acids Research
مصطلحات موضوعية: Transcription, Genetic, Receptors, Cell Surface, Gene Regulation, Chromatin and Epigenetics, Cell Line, Epigenesis, Genetic, chemistry.chemical_compound, Antigens, CD, Genetics, Animals, Humans, Epigenetics, Nucleotide Motifs, Gene, Polymerase, biology, DNA synthesis, RecQ Helicases, DNA Helicases, Helicase, Nuclear Proteins, DNA, Nucleotidyltransferases, Chromatin, Fanconi Anemia Complementation Group Proteins, Cell biology, G-Quadruplexes, Histone, chemistry, Mutation, biology.protein, REV1
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83a59dc4de25a0266ee78fae7074f46Test
http://europepmc.org/articles/PMC3287192Test
