المؤلفون: Zhao, Chunlong, Chen, Deng, Suo, Feng-zhi, Setroikromo, Rita, Quax, Wim J., Dekker, Frank

المصدر: Zhao , C , Chen , D , Suo , F , Setroikromo , R , Quax , W J & Dekker , F 2023 , ' Discovery of highly potent HDAC8 PROTACs with anti-tumor activity ' , Bioorganic Chemistry , vol. 136 , 106546 . https://doi.org/10.1016/j.bioorg.2023.106546Test

مصطلحات موضوعية: Humans, Repressor Proteins, Proteolysis Targeting Chimera, Cell Line, Tumor, Histone Deacetylases/metabolism, Jurkat Cells, Proteolysis, Histone Deacetylase Inhibitors/pharmacology

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/3d9675c4-ed9f-42b6-a5ce-db018f138559Test

الإتاحة: https://doi.org/10.1016/j.bioorg.2023.106546Test
https://hdl.handle.net/11370/3d9675c4-ed9f-42b6-a5ce-db018f138559Test
https://research.rug.nl/en/publications/3d9675c4-ed9f-42b6-a5ce-db018f138559Test
https://pure.rug.nl/ws/files/643992592/1_s2.0_S0045206823002067_main.pdfTest

المؤلفون: Pu, Jingjing, Liu, Ting, Sharma, Amit, Schmidt-Wolf, Ingo G H

المصدر: BMC medical genomics 16(1), 295 (2023). doi:10.1186/s12920-023-01724-3

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Humans, Histone Deacetylases: genetics, Histone Deacetylases: metabolism, Histone Deacetylase 6, Histone Deacetylase Inhibitors: pharmacology, Histone Deacetylase Inhibitors: therapeutic use, MicroRNAs: genetics, Multiple Myeloma: drug therapy, Multiple Myeloma: genetics, Histone Deacetylases, Cancer, Epigenetics, Non-coding genome, Histone Deacetylase Inhibitors, MicroRNAs

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:37978516; info:eu-repo/semantics/altIdentifier/issn/1755-8794; https://pub.dzne.de/record/266012Test; https://pub.dzne.de/search?p=id:%22DZNE-2023-01086%22Test

الإتاحة: https://doi.org/10.1186/s12920-023-01724-3Test
https://pub.dzne.de/record/266012Test
https://pub.dzne.de/search?p=id:%22DZNE-2023-01086%22Test

المؤلفون: Lo Cascio, Costanza, Margaryan, Tigran, Luna-Melendez, Ernesto, McNamara, James B, White, Connor I, Knight, William, Ganta, Saisrinidhi, Opachich, Zorana, Cantoni, Claudia, Yoo, Wonsuk, Sanai, Nader, Tovmasyan, Artak, Mehta, Shwetal

المصدر: Translational Neuroscience

مصطلحات موضوعية: Brain cancer, Drug therapy, Oncology, Radiation therapy, Therapeutics, Adult, Humans, Child, Histone Deacetylase Inhibitors (pharmacology, therapeutic use), Glioblastoma (drug therapy, radiotherapy), Hydroxamic Acids (pharmacology, Histone Deacetylases (metabolism), Brain Neoplasms (drug therapy, Protein Isoforms (metabolism), Brain (metabolism)

العلاقة: https://scholar.barrowneuro.org/neurobiology/2362Test; https://doi.org/10.1172/jci.insight.167081Test

الإتاحة: https://doi.org/10.1172/jci.insight.167081Test
https://scholar.barrowneuro.org/neurobiology/2362Test

المؤلفون: Andersen, Phillip Alexander Keller, Petrenko, Volodymyr, Rose, Peter Horskjær, Koomen, Melissa, Fischer, Nico, Ghiasi, Seyed Mojtaba, Dahlby, Tina, Dibner, Charna, Mandrup-Poulsen, Thomas

المصدر: ISSN: 1661-6596 ; International Journal of Molecular Sciences, vol. 22, no. 1 (2020) 83.

مصطلحات موضوعية: info:eu-repo/classification/ddc/612, info:eu-repo/classification/ddc/616, ARNTL Transcription Factors/genetics/metabolism, Animals, Cell Line, Tumor, Cells, Cultured, Circadian Rhythm, Female, HEK293 Cells, Histone Deacetylases/metabolism, Humans, Insulin/metabolism, Insulin-Secreting Cells/drug effects/metabolism, Interferon-gamma/metabolism/pharmacology, Male, Mice, Nitric Oxide/metabolism, Proteasome Endopeptidase Complex/metabolism, Reactive Oxygen Species/metabolism

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33374803; https://archive-ouverte.unige.ch/unige:154823Test; unige:154823

الإتاحة: https://doi.org/10.3390/ijms22010083Test
https://archive-ouverte.unige.ch/unige:154823Test

المؤلفون: Ana Katušić-Bojanac, Milvija Plazibat, Marta Himelreich-Perić, Katarina Eck-Raković, Jure Krasić, Nino Sinčić, Gordana Jurić-Lekić, Davor Ježek, Floriana Bulić-Jakuš

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8861

مصطلحات موضوعية: Placenta, Histone Deacetylases, Catalysis, Inorganic Chemistry, Pregnancy, Animals, Humans, Physical and Theoretical Chemistry, valproate, HDACi, neural tissue, ectoplacental cone, embryo, Molecular Biology, Spectroscopy, Placenta / metabolism, Mammals, Valproic Acid / pharmacology, Valproic Acid, Organic Chemistry, Gastrulation, Mammals / metabolism, Acetylation, General Medicine, Histone Deacetylase Inhibitors / pharmacology, Computer Science Applications, Rats, Histone Deacetylase Inhibitors, Histone Deacetylases / metabolism, Female

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94172e33185d6c105d2d22ab302ee8bTest

المؤلفون: Ronin, C, Costa, DM, Tavares, J, Faria, J, Ciesielski, F, Ciapetti, P, Smith, TK, MacDougall, J, Cordeiro-da-Silva, A, Pemberton, I

المساهمون: Instituto de Investigação e Inovação em Saúde

مصطلحات موضوعية: Binding Site, Crystallography, X-Ray, Drug Design, Group III Histone Deacetylases / chemistry, Group III Histone Deacetylases / metabolism, Humans, Leishmania infantum / metabolismo, Models, Molecular, Peptides / metabolism, Protein Binding, Protein Structure, Secondary, Protozoan Proteins / chemistry, Protozoan Proteins / metabolism

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/EC/FP7/602773/EU; PLoS ONE, vol.13(3):e0193602; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193602Test; https://hdl.handle.net/10216/127391Test

الإتاحة: https://doi.org/10.1371/journal.pone.0193602Test
https://hdl.handle.net/10216/127391Test

المساهمون: Others, Severance Hospital, Woo Sun Kwon, Sun Young Rha, Hei-Cheul Jeung, Tae Soo Kim, Hyun Cheol Chung, Kim, Tae Soo, Rha, Sun Young, Chung, Hyun Cheol, Jeung, Hei Cheul

مصطلحات موضوعية: Acetylation/drug effects, Amino Acid Substitution, Antineoplastic Agents, Phytogenic/pharmacology, Antineoplastic Combined Chemotherapy Protocols/pharmacology, BRCA2 Protein/genetics, BRCA2 Protein/metabolism, Breast Neoplasms/drug therapy, Breast Neoplasms/genetics, Breast Neoplasms/metabolism, Cell Line, Tumor, Cell Survival/drug effects, Drug Resistance, Neoplasm/drug effects, Female, Heterozygote, Histone Deacetylase Inhibitors/pharmacology, Histone Deacetylases/chemistry, Histone Deacetylases/metabolism, Humans, Mutation, Neoplasm Proteins/antagonists & inhibitors, Neoplasm Proteins/genetics, Neoplasm Proteins/metabolism, Paclitaxel/pharmacology, Polymorphism, Single Nucleotide, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/metabolism

العلاقة: BIOCHEMICAL PHARMACOLOGY; J00283; OAK-2017-03170; https://ir.ymlib.yonsei.ac.kr/handle/22282913/160319Test; https://www.sciencedirect.com/science/article/pii/S0006295217302320Test; T201702086; BIOCHEMICAL PHARMACOLOGY, Vol.138 : 163-173, 2017

الإتاحة: https://doi.org/10.1016/j.bcp.2017.04.015Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160319Test
https://www.sciencedirect.com/science/article/pii/S0006295217302320Test

المساهمون: College of Medicine, Dept. of Surgery, Hyun-Wook Ryu, Dong-Hee Shin, Dong Hoon Lee, Junjeong Choi, Gyoonhee Han, Kang Young Lee, So Hee Kwon, Lee, Kang Young

مصطلحات موضوعية: Apoptosis, HSP90 Heat-Shock Proteins/metabolism, Histone Deacetylase Inhibitors/pharmacology, Histone Deacetylase Inhibitors/therapeutic use, Histone Deacetylases/metabolism, Humans, Lysine, Tumor Suppressor Protein p53/metabolism, HDAC6-selective inhibitor, Histone deacetylase 6, Hsp90, p53

العلاقة: CANCER LETTERS; J00448; OAK-2017-00833; https://ir.ymlib.yonsei.ac.kr/handle/22282913/154678Test; http://www.sciencedirect.com/science/article/pii/S0304383517300757Test; T201700423; CANCER LETTERS, Vol.391 : 162-171, 2017

الإتاحة: https://doi.org/10.1016/j.canlet.2017.01.033Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154678Test
http://www.sciencedirect.com/science/article/pii/S0304383517300757Test

المساهمون: College of Medicine, Dept. of Internal Medicine, Jin-Hua Chi, Geom Seog Seo, Jae Hee Cheon, Sung Hee Lee, Cheon, Jae Hee

مصطلحات موضوعية: Acetylation/drug effects, Chalcones/pharmacology, Enzyme Activation/drug effects, HMGB1 Protein/secretion, HT29 Cells, Histone Deacetylases/metabolism, Humans, Inflammation Mediators/metabolism, Intestinal Mucosa/drug effects, Intestinal Mucosa/pathology, Intestinal Mucosa/secretion, NF-kappa B/metabolism, Tumor Necrosis Factor-alpha/pharmacology, High-mobility group box 1, Histone deacetylase, Inflammatory bowel disease, Intestinal epithelial cell, Isoliquiritigenin, Isoliquiritigenin (PubChem CID: 638278), Scriptaid (PubChem CID: 5186)

العلاقة: EUROPEAN JOURNAL OF PHARMACOLOGY; J00842; OAK-2017-01275; https://ir.ymlib.yonsei.ac.kr/handle/22282913/154547Test; http://www.sciencedirect.com/science/article/pii/S001429991630810XTest; T201700685; EUROPEAN JOURNAL OF PHARMACOLOGY, Vol.796 : 101-109, 2017

الإتاحة: https://doi.org/10.1016/j.ejphar.2016.12.026Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154547Test
http://www.sciencedirect.com/science/article/pii/S001429991630810XTest

المساهمون: College of Medicine, Dept. of Biochemistry & Molecular Biology, Mi-Hyeon Jeong, Hyeonseok Ko, Hyelin Jeon, Gi-Jun Sung, Soo-Yeon Park, Woo Jin Jun, Yoo-Hyun Lee, Jeongmin Lee, Sang-wook Lee, Ho-Geun Yoon, Kyung-Chul Choi, Park, Soo Yeon, Yoon, Ho Geun

مصطلحات موضوعية: Acetylation, Anthocyanins/pharmacology, Antineoplastic Agents, Phytogenic/pharmacology, Apoptosis, Caspase 3/metabolism, Caspase 7/metabolism, Caspase 8/metabolism, Cell Line, Tumor, Cell Survival, Epigenesis, Genetic, Gene Expression Regulation, Enzymologic, Neoplastic, Histone Deacetylases/genetics, Histone Deacetylases/metabolism, Humans, Male, Plant Extracts/pharmacology, Prostatic Neoplasms/drug therapy, Prostatic Neoplasms/genetics, Prostatic Neoplasms/metabolism, RNA Interference, Tumor Suppressor Protein p53/genetics, Tumor Suppressor Protein p53/metabolism, HDAC3, apoptosis, delphinidin

العلاقة: ONCOTARGET; J02421; OAK-2016-05304; https://ir.ymlib.yonsei.ac.kr/handle/22282913/152049Test; T201603562; ONCOTARGET , Vol.7(35) : 56767-56780, 2016; 46829

الإتاحة: https://doi.org/10.18632/oncotarget.10790Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152049Test