دورية أكاديمية
Metabolic changes in schizophrenia and human brain evolution
| العنوان: | Metabolic changes in schizophrenia and human brain evolution |
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| المؤلفون: | Khaitovich, P, Lockstone, HE, Wayland, MT, Tsang, TM, Jayatilaka, SD, Guo, AJ, Zhou, J, Somel, M, Harris, LW, Holmes, E, Paeaebo, S, Bahn, S |
| المصدر: | 11 ; 1 |
| بيانات النشر: | BMC |
| سنة النشر: | 2008 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Genetics & Heredity, MAGNETIC-RESONANCE-SPECTROSCOPY, FORMAL THOUGHT-DISORDER, GENE-EXPRESSION, HUMAN GENOME, POSITIVE SELECTION, NMR-SPECTROSCOPY, HOMO-SAPIENS, CORTEX, PROTON, DYSFUNCTION, Adult, Aged, Animals, Biological Evolution, Brain, Cognition, Energy Metabolism, Female, Gene Expression, Gene Expression Profiling, Humans, Macaca mulatta, Male, Middle Aged, Nuclear Magnetic Resonance, Biomolecular |
| الوصف: | Background Despite decades of research, the molecular changes responsible for the evolution of human cognitive abilities remain unknown. Comparative evolutionary studies provide detailed information about DNA sequence and mRNA expression differences between humans and other primates but, in the absence of other information, it has proved very difficult to identify molecular pathways relevant to human cognition. Results Here, we compare changes in gene expression and metabolite concentrations in the human brain and compare them to the changes seen in a disorder known to affect human cognitive abilities, schizophrenia. We find that both genes and metabolites relating to energy metabolism and energy-expensive brain functions are altered in schizophrenia and, at the same time, appear to have changed rapidly during recent human evolution, probably as a result of positive selection. Conclusion Our findings, along with several previous studies, suggest that the evolution of human cognitive abilities was accompanied by adaptive changes in brain metabolism, potentially pushing the human brain to the limit of its metabolic capabilities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1474-7596 |
| العلاقة: | Genome Biology; http://hdl.handle.net/10044/1/86624Test |
| DOI: | 10.1186/gb-2008-9-8-r124 |
| الإتاحة: | https://doi.org/10.1186/gb-2008-9-8-r124Test http://hdl.handle.net/10044/1/86624Test |
| حقوق: | © 2008 Khaitovich et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0Test), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited ; http://creativecommons.org/licenses/by/2.0Test |
| رقم الانضمام: | edsbas.3D5D8842 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14747596 |
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| DOI: | 10.1186/gb-2008-9-8-r124 |