المؤلفون: Capoccia Giovannini, S., Petersson, Ulf, Rogmark, P., De Beaux, A., East, B.

المصدر: The British journal of surgery. 111(1)

مصطلحات موضوعية: Delphi Technique, Hernia, Ventral, Herniorrhaphy, Humans, Incisional Hernia, Postoperative Complications, Surgical Mesh, abdominal wall hernia, Delphi study, hernia, herniorrhaphy, human, incisional hernia, postoperative complication, procedures, Medicin och hälsovetenskap, Klinisk medicin, Kirurgi, Medical and Health Sciences, Clinical Medicine, Surgery

الوصول الحر: https://lup.lub.lu.se/record/e7b2ea7a-f618-4242-a1fb-203361a1c8beTest
http://dx.doi.org/10.1093/bjs/znad346Test

المؤلفون: Guglielmi V., Marra C., Picciotti P. M., Giovannini S., Quaranta D., Anzivino R., Paludetti G., Conti G.

المساهمون: Guglielmi, V., Marra, C., Picciotti, P. M., Masone Iacobucci, G., Giovannini, S., Quaranta, D., Anzivino, R., Paludetti, G., Conti, G.

مصطلحات موضوعية: cognition, hearing loss, memory, Aged, 80 and over, Attention, Cognition Disorders, Executive Function, Female, Humans, Male, Memory Disorders, Neuropsychological Tests, Social Behavior, Settore MED/26 - NEUROLOGIA

الوصف: Background: It is well known that age-related hearing loss (ARHL) is strongly associated with dementia. Different hypotheses have been considered to explain this link, including sensorial deprivation, the reduction in cognitive reserve, and the presence of shared pathological pathways (microvascular damage of the brain). Aims: We carried out a study of the audiological and neuropsychological characteristics of a sample of hearing impaired but cognitively healthy individuals (HIH). The aim of our study was to carefully outline the neuropsychological profile of the patients in order to verify whether hearing loss correlated with deficits in specific cognitive domains. Results: Episodic memory is affected by the presence of hearing loss, while semantic competences, syntactic, and grammar skills seem not to be affected. Furthermore, some audiological features linked to the intelligibility of spoken words can predict the presence of executive dysfunction; the same does not apply to memory impairment. Conclusion: In HIH, executive functions are widely employed in maintaining an acceptable level of comprehension of spoken language; consequently, other cognitive domains and instrumental abilities in HIH are not properly supported. Thus, it is arguable that programs of hearing rehabilitation for HIH could restore the allocation of attentional resources to the functioning of other cognitive domains.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31522629; info:eu-repo/semantics/altIdentifier/wos/WOS:000489458500001; volume:33; issue:4; firstpage:231; lastpage:240; numberofpages:10; issueyear:2020; journal:JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY; http://hdl.handle.net/10807/179170Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85073958552

الإتاحة: https://doi.org/10.1177/0891988719874117Test
http://hdl.handle.net/10807/179170Test

المؤلفون: GIOVANNINI S., LORETI C., CORACI D., PADUA L., CALIANDRO P., ZEGA M., TAFANI A., CAMBIERI A., RUSSO A., RICCIOTTI M. A., MACCAURO G., BERNABEI R., BARILLARO C.

المساهمون: Giovannini, Silvia, Tamburrano, A., Sganga, F., Serra, M. L., Loreti, Claudia, Coraci, Daniele, Padua, Luca, Caliandro, Pietro, Zega, Maurizio, Tafani, Alessia, Cambieri, Andrea, Acampora, N., Russo, Andrea, Ricciotti, Maria Adelaide, Maccauro, Giulio, Laudisio, A., Bernabei, Roberto, Biscotti, L., Barillaro, Christian

مصطلحات موضوعية: Continuity of care, Discharge planning, Palliative care, Personalized medicine, Aged, Cohort Studies, Female, Hospice Care, Hospital Mortality, Hospitalization, Humans, Inpatients, Length of Stay, Male, Patient Discharge, Prospective Studies, Frail Elderly, Models, Nursing, Settore MED/09 - MEDICINA INTERNA, Settore MED/34 - MEDICINA FISICA E RIABILITATIVA

الوصف: OBJECTIVE: Delays in patient discharge can adversely affect hospital and emergency room productivity and increase healthcare costs. The discharge should be structured from the hospital admission towards the most appropriate environment. This study aims to investigate the efficacy of the Unit, named "Continuity of Care Center" (CCC), to guarantee a safest and fastest hospital discharge in frail patients and to test the effect of our team-approach on hospital outcomes (length of stay and hospital mortality). MATERIALS AND METHODS: This is a prospective cohort study carried out in an acute care hospital with 1,558 beds and is equipped with 41 operating theaters. We collected data from October 2016 to June 2019. RESULTS: The time of patient discharge had an important reduction: 15.5±30.8 in the first 3 months vs. 11.0±20.1 in the last 3 months considered. The median of the time of discharge in all 12 months considered was 12 day. The length of stay presented an important reduction from 33.3±47.5 during the first 3 months vs. 28.8±39.5 in the last 3 months of activity of CCC; and a significant reduction of hospital deaths was recorded from 20% during the first 3 months to 14% in the last 3 months of activity of CCC. CONCLUSIONS: Results indicate a constant decrease in patient discharge time and length of hospital stay, with a consequent significant reduction of healthcare costs. According to the estimates of Italian Health Ministry concerning Latium region, every hospitalization day has a mean cost of € 674.00. Thus, the CCC activity has contributed to a reduction of approximately 12,832 days of hospitalization, in the considered period, with an estimated hospital saving of € 8,648,761.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33378052; info:eu-repo/semantics/altIdentifier/wos/WOS:000601364400066; volume:25; issue:24; firstpage:13009; lastpage:13014; numberofpages:6; issueyear:2020; journal:EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES; http://hdl.handle.net/10807/204682Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099325397

الإتاحة: https://doi.org/10.26355/eurrev_202012_24206Test
http://hdl.handle.net/10807/204682Test

المؤلفون: Castelli L., Loreti C., Coraci D., Fusco A., Giovannini S., Padua L.

المساهمون: Castelli, Letizia, Loreti, Claudia, Coraci, Daniele, Fusco, Augusto, Biscotti, L., Giovannini, Silvia, Padua, Luca

مصطلحات موضوعية: Deprescribing, Frailty, Personalized medicine, Polypharmacy, Aged, Humans, Inappropriate Prescribing, Pandemics, SARS-CoV-2, COVID-19, Deprescriptions, Settore MED/09 - MEDICINA INTERNA, Settore MED/34 - MEDICINA FISICA E RIABILITATIVA

الوصف: N/A

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33288419; info:eu-repo/semantics/altIdentifier/wos/WOS:000633997800025; volume:17; issue:5; firstpage:1024; lastpage:1025; numberofpages:2; issueyear:2020; journal:RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY; http://hdl.handle.net/10807/204726Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85097798655

الإتاحة: https://doi.org/10.1016/j.sapharm.2020.11.016Test
http://hdl.handle.net/10807/204726Test

المؤلفون: Giovannini S., Onder G., Russo A., Bernabei R., Landi F.

المساهمون: Giovannini, Silvia, Onder, Graziano, Lattanzio, F., Bustacchini, S., di Stefano, G., Moresi, R., Russo, Andrea, Bernabei, Roberto, Landi, Francesco

مصطلحات موضوعية: frail elderly, mortality, Selenium, Aged, 80 and over, Female, Humans, Independent Living, Inflammation, Italy, Longevity, Male, Prospective Studies, Settore MED/09 - MEDICINA INTERNA, Settore MED/34 - MEDICINA FISICA E RIABILITATIVA

الوصف: Background: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population. Objectives: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults. Design and Setting: Data are from the ‘Invecchiamento e Longevità nel Sirente’ (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up. Participants and measurements: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium. Results: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92). Conclusions: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29717761; info:eu-repo/semantics/altIdentifier/wos/WOS:000432630800009; volume:22; issue:5; firstpage:608; lastpage:612; numberofpages:5; issueyear:2018; journal:THE JOURNAL OF NUTRITION, HEALTH & AGING; http://hdl.handle.net/10807/206076Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85044218223

الإتاحة: https://doi.org/10.1007/s12603-018-1021-9Test
http://hdl.handle.net/10807/206076Test

المؤلفون: Federico Biscetti, Giovannini, S., Straface, G., Bertucci, F., Angelini, F., Porreca, C., Landolfi, R., Flex, A.

المصدر: Scopus-Elsevier
Europe PubMed Central

مصطلحات موضوعية: Male, history of ischemic stroke, RANK Ligand, Settore MED/09 - MEDICINA INTERNA, Osteoprotegerin, Polymorphism, Single Nucleotide, RANK/RANKL/OPG pathway, Stroke, Italy, Gene Polymorphism, Humans, Female, Genetic Association Studies, Retrospective Studies

الوصف: RANKL is a member of the TNF superfamily that stimulates chemokine release, monocyte/macrophage matrix migration and matrix metalloproteinase activity and plays an important role in atherosclerosis. In our study, we have evaluated whether RANKL gene polymorphisms are involved in ischemic stroke in Italian subjects.In a retrospective study we have included 487 patients (242 males, 245 females) with history of ischemic stroke and 543 control subjects without history of ischemic stroke (277 males, 276 females). The rs9533156, and rs2277438 gene polymorphisms of the RANKL gene were analyzed by PCR and restriction fragment length polymorphism.We found that the rs9533156 gene polymorphism of the RANKL gene was significantly (55.0% versus 36.5%, p0.0001) and independently (adjusted OR 6.28 [2.34-4.21]) associated with history of ischemic stroke. No statistically significant difference was found between the two groups in our population for the rs2277438 gene polymorphism (p = 439). Furthermore, we have confirmed that rs 3134069, rs 2073617 and rs 2073618 polymorphisms of the OPG gene were significantly and independently associated with cerebrovascular disorders.The present study identifies, for the first time, the genetic variant of RANKL as an independent risk factor for ischemic stroke.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9cc60b6423b3104d541a51d67d1489fcTest
http://hdl.handle.net/10807/92511Test

المؤلفون: Gobbi, G, Giovannini, S, Boni, A, Visconti, P, Beghi, M, CORNAGGIA, CESARE MARIA

المساهمون: Gobbi, G, Giovannini, S, Boni, A, Visconti, P, Beghi, M, Cornaggia, C

المصدر: Epileptic disorders : international epilepsy journal with videotape. 10(4)

مصطلحات موضوعية: Adolescent, Schizophrenia, Catatonic, epilepsy forced normalization, Infant, Electroencephalography, Epilepsies, Myoclonic, Child Behavior Disorders, Syndrome, Child Development Disorders, Pervasive, Seizures, Intellectual Disability, Humans, Anticonvulsants, Female

الوصف: It has been reported that the clinical presentation of forced normalization can vary from paranoid hallucinatory states to anxiety and conversion phenomena, and that it may occur in both generalised and focal epilepsies. On the basis of the evaluation of a video recording, we found that forced normalization was concomitant with catatonic psychosis in a patient with epilepsy, intellectual disability and pervasive developmental disorder. Catatonic psychosis accompanying forced normalization has not been previously reported. As the psychotic symptoms and quality of life worsen seizure control improves, we believe it may be better for the patient to tolerate some seizures, thus preserving their capacity to interact socially.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e1b26afd6e3fb095564a7f23e94cf59Test
https://pubmed.ncbi.nlm.nih.gov/19017576Test

المؤلفون: Landi, Francesco, Liperoti, Rosa, Giovannini, S, Tosato, Matteo, Bernabei, Roberto, Onder, Graziano

المساهمون: Landi, Francesco, Cruz Jentoft, Aj, Liperoti, Rosa, Russo, A, Giovannini, Silvia, Tosato, Matteo, Capoluongo, E, Bernabei, Roberto, Onder, Graziano

مصطلحات موضوعية: Aging, Frail Elderly, Age Factors, Aged, 80 and over, Analysis of Variance, Cause of Death, Female, Geriatric Assessment, Hand Strength, Humans, Independent Living, Italy, Kaplan-Meier Estimate, Male, Muscle, Skeletal, Prognosis, Proportional Hazards Models, Prospective Studies, Risk Assessment, Risk Factors, Sarcopenia, Time Factors, Settore MED/09 - MEDICINA INTERNA

الوصف: sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals. We evaluated the impact of sarcopenia on the risk of all-cause death in a population of frail older persons living in community.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23321202; info:eu-repo/semantics/altIdentifier/wos/WOS:000316157400013; volume:42; issue:2; firstpage:203; lastpage:209; numberofpages:7; issueyear:2013; journal:AGE AND AGEING; http://hdl.handle.net/10807/60523Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84874550714

الإتاحة: https://doi.org/10.1093/ageing/afs194Test
http://hdl.handle.net/10807/60523Test

المؤلفون: Landi, Francesco, Liperoti, Rosa, Giovannini, S, Bernabei, Roberto, Onder, Graziano

المساهمون: Landi, Francesco, Liperoti, Rosa, Russo, A, Giovannini, Silvia, Tosato, M, Barillaro, C, Capoluongo, E, Bernabei, Roberto, Onder, Graziano

مصطلحات موضوعية: Aging, Activities of Daily Living, Aged, 80 and over, Anorexia, Cohort Studies, Comorbidity, Cross-Sectional Studies, Female, Frail Elderly, Geriatric Assessment, Hand Strength, Humans, Italy, Male, Motor Activity, Practice Guidelines as Topic, Prospective Studies, Risk, Sarcopenia, Urinary Incontinence, Settore MED/09 - MEDICINA INTERNA

الوصف: There is increasing evidence that anorexia of aging can cause physical and mental impairment. The aim of the present study was to evaluate the relationship between anorexia and sarcopenia in elderly persons aged 80 years or older.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/22923016; info:eu-repo/semantics/altIdentifier/wos/WOS:000317078900040; volume:52; issue:3; firstpage:1261; lastpage:1268; numberofpages:8; issueyear:2013; journal:EUROPEAN JOURNAL OF NUTRITION; http://hdl.handle.net/10807/60525Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84879556337

الإتاحة: https://doi.org/10.1007/s00394-012-0437-yTest
http://hdl.handle.net/10807/60525Test

المؤلفون: Clerico, A, Zaninotto, M, Prontera, C, Giovannini, S, Ndreu, R, Franzini, M, Zucchelli, Gc, Plebani, Mario, Study Group on Cardiovascular Risk Biomarkers of the Italian Society of Clinical Biochemistry

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Cardiovascular biomarkers, Point-of-care testing, Clinical Biochemistry, Clinical biochemistry, Biochemistry, Natriuretic Peptide, Internal medicine, Natriuretic Peptide, Brain, medicine, Proficiency testing, Humans, ADVIA Centaur, cardiovascular diseases, Natriuretic peptides, Immunoassay, medicine.diagnostic_test, business.industry, Medicine (all), Biochemistry (medical), Quality control, Brain, Reproducibility of Results, General Medicine, NT-proBNP, BNP, business, BNP NT-proBNP Natriuretic peptides Immunoassay Quality control, hormones, hormone substitutes, and hormone antagonists

الوصف: article i nfo To evaluate differences in analytical performance and clinical results of BNP and NT-proBNP immunoassays, a proficiency testing program, called CardioOrmoCheck study, has been organized since 2005 under the patronage of the Study Group of the Cardiovascular Biomarkers of the Italian Society of Clinical Biochemistry (SIBIOC). On average more than 100 Italian laboratories were involved in the annual 2005-2011 cycles. In total, 72 study samples were distributed and measured by participant laboratoriesfor a total of 6706 results. A great difference in between-method variability was found between BNP (43.0 CV%) and NT-proBNP (8.7 CV%) immunoassays. However, with the only exception of the POCT method for BNP assay, all immunoassay methods showed an imprecision≤10 CV% at the cut-off levels (i.e. 100 ng/L for BNP and 400 ng/L for NT-proBNP assay, respectively). Furthermore, CardioOrmoCheck study demonstrated that the most popular BNP immunoassays are affected by large systematic differences (on average more than 2 folds between TRIAGE Beckman-Coulter and ADVIA Centaur Siemens methods), while the agreement between NT-proBNP methods was better. CardioOrmoCheck study demonstrates that there are marked differences in analytical performance and measured values in particular among commercial methods for BNP assay. These findings suggest that it may be not reasonable to recommend identical cut-off or decision values for all BNP immunoassays.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d6398ad61bee421f20b94e13e30505Test
http://hdl.handle.net/11577/2578503Test