التفاصيل البيبلوغرافية
| العنوان: |
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. |
| المؤلفون: |
Kilpeläinen, T.O., Zillikens, M.C., Stančákova, A., Finucane, F.M., Ried, J.S., Langenberg, C., Zhang, W., Beckmann, J.S., Luan, J., Vandenput, L., Styrkarsdottir, U., Zhou, Y., Smith, A.V., Zhao, J.H., Amin, N., Vedantam, S., Shin, S.Y., Haritunians, T., Fu, M., Feitosa, M.F., Kumari, M., Halldorsson, B.V., Tikkanen, E., Mangino, M., Hayward, C., Song, C., Arnold, A.M., Aulchenko, Y.S., Oostra, B.A., Campbell, H., Cupples, L.A., Davis, K.E., Döring, A., Eiriksdottir, G., Estrada, K., Fernández-Real, J.M., Garcia, M., Gieger, C., Glazer, N.L., Guiducci, C., Hofman, A., Humphries, S.E., Isomaa, B., Jacobs, L.C., Jula, A., Karasik, D., Karlsson, M.K., Khaw, K.T., Kim, L.J., Kivimäki, M., Klopp, N., Kühnel, B., Kuusisto, J., Liu, Y., Ljunggren, O., Lorentzon, M., Luben, R.N., McKnight, B., Mellström, D., Mitchell, B.D., Mooser, V., Moreno, J.M., Männistö, S., O'Connell, J.R., Pascoe, L., Peltonen, L., Peral, B., Perola, M., Psaty, B.M., Salomaa, V., Savage, D.B., Semple, R.K., Skaric-Juric, T., Sigurdsson, G., Song, K.S., Spector, T.D., Syvänen, A.C., Talmud, P.J., Thorleifsson, G., Thorsteinsdottir, U., Uitterlinden, A.G., van Duijn, C.M., Vidal-Puig, A., Wild, S.H., Wright, A.F., Clegg, D.J., Schadt, E., Wilson, J.F., Rudan, I., Ripatti, S., Borecki, I.B., Shuldiner, A.R., Ingelsson, E., Jansson, J.O., Kaplan, R.C., Gudnason, V., Harris, T.B., Groop, L., Kiel, D.P., Rivadeneira, F., Walker, M., Barroso, I., Vollenweider, P., Waeber, G., Chambers, J.C., Kooner, J.S., Soranzo, N., Hirschhorn, J.N., Stefansson, K., Wichmann, H.E., Ohlsson, C., O'Rahilly, S., Wareham, N.J., Speliotes, E.K., Fox, C.S., Laakso, M., Loos, R.J. |
| المصدر: |
Nature Genetics, vol. 43, no. 8, pp. 753-760 |
| سنة النشر: |
2011 |
| المجموعة: |
Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: |
Adiponectin/blood, Adiposity/genetics, Alleles, Body Fat Distribution, Body Mass Index, Body Weight, Female, Genetic Variation/genetics, Genome-Wide Association Study, Humans, Insulin Receptor Substrate Proteins/genetics, Intracellular Signaling Peptides and Proteins/genetics, Male, Meta-Analysis as Topic, Metabolome/genetics, Obesity/genetics, Polymorphism, Single Nucleotide/genetics, Subcutaneous Fat |
| الوصف: |
Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10(-6)) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10(-11)) and one near SPRY2 (P = 3 × 10(-8)). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
1061-4036 |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/21706003; info:eu-repo/semantics/altIdentifier/eissn/1546-1718; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_342B86FD2B660; https://serval.unil.ch/notice/serval:BIB_342B86FD2B66Test; urn:issn:1061-4036; https://serval.unil.ch/resource/serval:BIB_342B86FD2B66.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_342B86FD2B660Test |
| DOI: |
10.1038/ng.866 |
| الإتاحة: |
https://doi.org/10.1038/ng.866Test
https://serval.unil.ch/notice/serval:BIB_342B86FD2B66Test
https://serval.unil.ch/resource/serval:BIB_342B86FD2B66.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_342B86FD2B660Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimerTest |
| رقم الانضمام: |
edsbas.6094D7EC |
| قاعدة البيانات: |
BASE |
