المؤلفون: Christopher J. Mungall, Matthias Haimel, Fabian Hauck, Marc Hanauer, Nicolas Matentzoglu, Ganna Balagura, Ingo Helbig, Julie A. McMurry, Avi Z. Rosenberg, Amy Brower, Johanna L. Est, Julia Pazmandi, Maximilian Hastreiter, Melissa A. Haendel, Peter D. Galer, Nomi L. Harris, Gerhard Kindle, Michael Hartnett, Daniel Danis, Hugh Kearney, Shiva Ganesan, Yongqun He, Michael A. Gargano, Rebecca L. Peters, Matthias Griese, Roland Krause, Damian Smedley, Shahmir A. Rind, Katrin Knoflach, Tim Jeske, Gareth Baynam, Peter N. Robinson, Michael M. Segal, Leigh C. Carmody, David Lagorce, Monica Munoz-Torres, Christopher G. Chute, Christoph Klein, Zafer Yüksel, Jillian A. Miller, Tomer Talmy, Christina K Rapp, Julie Xian, Tiffany J. Callahan, Samuel A. Wiafe, David Lewis-Smith, Ana Rath, Nicole Vasilevsky, Yarlalu Thomas, Markus G. Seidel, Sebastian Köhler

المصدر: Nucleic Acids Research, 2021, Vol. 49
Nucleic Acids Research

مصطلحات موضوعية: endocrine system, Databases, Factual, Genotype, AcademicSubjects/SCI00010, International Cooperation, Biology, 03 medical and health sciences, 0302 clinical medicine, Human disease, Neonatal Screening, Electronic health record, Terminology as Topic, Human Phenotype Ontology, Genetics, Database Issue, Animals, Humans, Disease, 030304 developmental biology, 0303 health sciences, Internet, Genome, Extramural, fungi, Infant, Newborn, Computational Biology, Biological Ontologies, equipment and supplies, Data science, body regions, Disease Models, Animal, Phenotype, Pharmacogenetics, Clinical validity, International league against epilepsy, 030217 neurology & neurosurgery, Software

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf63733a75073d0317ef693d3429b7cTest

المؤلفون: Céline M. Labbé, Mélaine A. Kuenemann, David Lagorce, Bruno O. Villoutreix, Maria A. Miteva, Olivier Sperandio

المصدر: Progress in Biophysics and Molecular Biology. 119:20-32

مصطلحات موضوعية: Virtual screening, Computer science, Drug discovery, In silico, Biophysics, food and beverages, Ligands, Bioinformatics, Molecular Weight, Small Molecule Libraries, Cheminformatics, Drug Design, Animals, Humans, Computer Simulation, Low molecular weight protein, Protein Interaction Maps, Molecular Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24de5503643d33b8e21c9847753d816Test
https://doi.org/10.1016/j.pbiomolbio.2015.02.006Test

المؤلفون: Naziha Bakouh, Dominique Eladari, Maxime Louet, Maria A. Miteva, Bruno O. Villoutreix, Yohan Bignon, Gabrielle Planelles, Jacques Teulon, Sara Bitam, David Lagorce

المساهمون: Molécules Thérapeutiques in silico (MTI), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR), Service d’Explorations Fonctionnelles Rénales, Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion], HAL UPMC, Gestionnaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Molécules Thérapeutique in silico, Recherche de molécules à visée thérapeutique par approches In Silico ( MTI ), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche des Cordeliers ( CRC ), Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Diabète athérothrombose et thérapies Réunion Océan Indien ( DéTROI ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de la Réunion ( UR ), CHU Félix Guyon, Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE)

المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.7249. ⟨10.1038/s41598-017-07794-5⟩
Scientific Reports, 2017, 7, pp.7249. ⟨10.1038/s41598-017-07794-5⟩
Scientific Reports, Nature Publishing Group, 2017, 7, pp.7249. 〈10.1038/s41598-017-07794-5〉
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Quantitative structure–activity relationship, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Protein Conformation, Science, [CHIM.THER] Chemical Sciences/Medicinal Chemistry, In silico, Drug Evaluation, Preclinical, Quantitative Structure-Activity Relationship, Computational biology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Pharmacology, Bartter syndrome, Article, Membrane Potentials, 03 medical and health sciences, Protein structure, Chlorides, Chloride Channels, medicine, Animals, Humans, Amino Acid Sequence, Membrane potential, Virtual screening, Multidisciplinary, Molecular Structure, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Chemistry, [ CHIM.THER ] Chemical Sciences/Medicinal Chemistry, medicine.disease, 3. Good health, Drug repositioning, 030104 developmental biology, Mutation, Chloride channel, Medicine, Cattle, Disease Susceptibility, Ion Channel Gating, [ SDV.BBM.BS ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc71b54f23fb0454d678dbf974777f4Test
https://hal.sorbonne-universite.fr/hal-01580157/file/s41598-017-07794-5.pdfTest

المؤلفون: Céline M. Labbé, Olivier Sperandio, David Lagorce, Bruno O. Villoutreix, Maria A. Miteva

المصدر: Drug Discovery Today. 18:1081-1089

مصطلحات موضوعية: Pharmacology, Internet, Databases, Factual, Drug discovery, business.industry, Process (engineering), Computer science, World Wide Web, Drug Design, Drug Discovery, Computer-Aided Design, Humans, Computer Simulation, The Internet, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b478ed4ca433caaf4c5c440c1b27fd6Test
https://doi.org/10.1016/j.drudis.2013.06.013Test

المؤلفون: Zhe Zhang, David Lagorce, Emil Alexov, Virginie Y. Martiny, Maria A. Miteva, Yoshihiko Ikeguchi

المصدر: PLoS ONE, Vol 9, Iss 10, p e110884 (2014)
PLoS ONE

مصطلحات موضوعية: Protein Conformation, Chemistry, Pharmaceutical, Spermine Synthase, Mutant, Biophysics, Mutation, Missense, lcsh:Medicine, Molecular Dynamics Simulation, Crystallography, X-Ray, Protein structure, Intellectual Disability, Protein Interaction Mapping, Humans, Binding site, lcsh:Science, Genetics, Virtual screening, Binding Sites, Multidisciplinary, biology, Chemistry, lcsh:R, Rational design, Biology and Life Sciences, Computational Biology, Small molecule, Spermine synthase, Drug Design, Mutation, Mental Retardation, X-Linked, biology.protein, Thermodynamics, lcsh:Q, Protein Multimerization, Small molecule binding, Research Article, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca27c4ced8eeedc3221e35f57cf57301Test
http://europepmc.org/articles/PMC4207787?pdf=renderTest

المؤلفون: David Lagorce, Christian Bréchot, Claude Mugnier, Tetsuro Urashima, Yoshiki Murakami, Patrizia Paterlini-Bréchot, Mounia Chami, Takeshi Okanoue, Kenichi Saigo, Devrim Gozuacik

المصدر: Oncogene. 20:6233-6240

مصطلحات موضوعية: Hepatitis B virus, Cancer Research, Carcinoma, Hepatocellular, DNA, Complementary, Molecular Sequence Data, medicine.disease_cause, Polymerase Chain Reaction, Genome, Insertional mutagenesis, Exon, Genetics, medicine, Humans, Molecular Biology, Gene, Repetitive Sequences, Nucleic Acid, Mutation, Base Sequence, Models, Genetic, biology, Cancer, DNA, Exons, Blotting, Northern, medicine.disease, biology.organism_classification, Virology, Molecular biology, Introns, digestive system diseases, Hepadnaviridae, Cell Division

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbb76b6a7e6b7778f89e7e62c4ec5d0Test
https://doi.org/10.1038/sj.onc.1204835Test

المؤلفون: Pablo Carbonell, Gautier Moroy, Bruno O. Villoutreix, Maria A. Miteva, David Lagorce, Virginie Y. Martiny

المصدر: PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e73587 (2013)

مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, In silico, Science, Quantitative Structure-Activity Relationship, Computational biology, Molecular Dynamics Simulation, Bioinformatics, Crystallography, X-Ray, Ligands, 01 natural sciences, Xenobiotics, Small Molecule Libraries, 03 medical and health sciences, 0103 physical sciences, Humans, Computer Simulation, Binding site, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Binding Sites, 010304 chemical physics, Molecular Structure, Chemistry, Ligand (biochemistry), Small molecule, Arylsulfotransferase, 3. Good health, Protein Structure, Tertiary, Docking (molecular), Medicine, Thermodynamics, Small molecule binding, Sulfotransferases, Research Article, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df34ff7e23334479f964e7ad71caccb9Test
http://europepmc.org/articles/PMC3765257Test

المؤلفون: Francesca De Giorgi, Naoual L Benali-Furet, François Ichas, Patrizia Paterlini-Bréchot, Rosario Rizzuto, Ludivine Houel, David Lagorce, Mounia Chami, Ralf Bartenschlager, Fabienne Vernejoul, Louis Buscail

المساهمون: CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Carcinogenèse Hépatique et Virologie Moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Ferrara (UniFE), Signalisation et Mecanismes Moleculaires de l'Apoptose, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie et Pathologie Digestive, IFR 31 Louis Bugnard (IFR 31), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Molecular Virology, Universität Heidelberg [Heidelberg]

المصدر: Oncogene
Oncogene, Nature Publishing Group, 2005, 24 (31), pp.4921-33

مصطلحات موضوعية: Cancer Research, [SDV]Life Sciences [q-bio], aequorin, Hepacivirus, Endoplasmic Reticulum, Membrane Potentials, Mice, 0302 clinical medicine, LIVER-CANCER, Promoter Regions, Genetic, Endoplasmic Reticulum Chaperone BiP, Calcium signaling, 0303 health sciences, 3. Good health, Cell biology, Mitochondria, APOPTOSIS, cell death, Liver, 030220 oncology & carcinogenesis, HCV, ER stress, Liver cancer, Programmed cell death, HVC Core, chemistry.chemical_element, Mice, Transgenic, Calcium, Biology, Transfection, Models, Biological, 03 medical and health sciences, HCV core, Cell Line, Tumor, Genetics, In Situ Nick-End Labeling, Animals, Humans, Molecular Biology, 030304 developmental biology, Calcium metabolism, Apoptosis, Calcium signalling, Endoplasmic reticulum, Intracellular Membranes, Virology, CALCIUM SIGNALLING, Calcium ATPase, Mice, Inbred C57BL, chemistry, Unfolded protein response, endoplasmic reticulum, mitochondria

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328c4f3d8796110062c44fe0770ef41eTest
https://hal.archives-ouvertes.fr/hal-01259965Test

المؤلفون: Yoshiki Murakami, Kenichi Saigo, David Lagorce, Patrizia Paterlini-Bréchot, Christian Bréchot, Claude Mugnier, Devrim Gozuacik, Mounia Chami

المصدر: Oncogene. 22(25)

مصطلحات موضوعية: Therapeutic gene modulation, Ribosomal Proteins, Cancer Research, Hepatitis B virus, Carcinoma, Hepatocellular, beta-Galactoside alpha-2,3-Sialyltransferase, Virus Integration, Receptors, Cytoplasmic and Nuclear, Calcium-Transporting ATPases, Biology, medicine.disease_cause, Polymerase Chain Reaction, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Insertional mutagenesis, Genetics, medicine, Humans, Inositol 1,4,5-Trisphosphate Receptors, Receptor, trkB, 5-HT5A receptor, Telomerase reverse transcriptase, Molecular Biology, Gene, Telomerase, Mitogen-Activated Protein Kinase 1, Liver cell, Liver Neoplasms, DNA, Neoplasm, Hepatitis B, IRAK2, Sialyltransferases, Neoplasm Proteins, DNA-Binding Proteins, Mutagenesis, Insertional, Interleukin-1 Receptor-Associated Kinases, DNA, Viral, Cancer research, Calcium Channels, Protein Kinases, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4729af07be1ccba2f2c4cac9a85d95Test
https://pubmed.ncbi.nlm.nih.gov/12813464Test

المؤلفون: Yoshiki Murakami, David Lagorce, Esther Biermann, Rolf Knippers, Mounia Chami, Jamila Faivre, Patrizia Paterlini-Bréchot, Devrim Gozuacik, Christian Bréchot, Olivier Poch

مصطلحات موضوعية: DNA, Complementary, Blotting, Western, Molecular Sequence Data, Gene Expression, Cell Cycle Proteins, Biology, Cell Line, S Phase, Evolution, Molecular, Minichromosome maintenance, Genetics, Tumor Cells, Cultured, Humans, RNA, Messenger, Nuclear protein, Cloning, Molecular, Conserved Sequence, Phylogeny, MCM8, Minichromosome Maintenance Proteins, DNA replication, G1 Phase, Nuclear Proteins, Articles, Sequence Analysis, DNA, Cell cycle, Molecular biology, MCM Protein, Chromatin, Multigene Family, Origin recognition complex, HeLa Cells, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6c9fe965873b17ae2b30ad87de6352Test
https://europepmc.org/articles/PMC140502Test/