المؤلفون: Jacob Horsager, Niels Okkels, Allan K. Hansen, Malene F. Damholdt, Katrine H. Andersen, Tatyana D. Fedorova, Ole Lajord Munk, Erik H. Danielsen, Nicola Pavese, David J. Brooks, Per Borghammer

المصدر: Horsager, J, Okkels, N, Hansen, A K, Damholdt, M F, Andersen, K H, Fedorova, T D, Munk, O L, Danielsen, E H, Pavese, N, Brooks, D J & Borghammer, P 2022, ' Mapping Cholinergic Synaptic Loss in Parkinson's Disease : An [18F]FEOBV PET Case-Control Study ', Journal of Parkinson's Disease, vol. 12, no. 8, pp. 2493-2506 . https://doi.org/10.3233/JPD-223489Test

مصطلحات موضوعية: Cellular and Molecular Neuroscience, positron emission tomography, vesicular acetylcholine transporter, Case-Control Studies, Positron-Emission Tomography, Parkinson’s disease, [18F]FEOBV, Cholinergic Agents, Disease Progression, Humans, Parkinson Disease, Neurology (clinical), Cholinergic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754f8a7539bb7452ec182e565da60e8bTest
https://doi.org/10.3233/jpd-223489Test

المؤلفون: Fangda Leng, Rainer Hinz, Steve Gentleman, Adam Hampshire, Melanie Dani, David J. Brooks, Paul Edison

المصدر: Leng, F, Hinz, R, Gentleman, S, Hampshire, A, Dani, M, Brooks, D J & Edison, P 2022, ' Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease ', Molecular psychiatry . https://doi.org/10.1038/s41380-022-01878-zTest
Leng, F, Hinz, R, Gentleman, S, Hampshire, A, Dani, M, Brooks, D J & Edison, P 2023, ' Neuroinflammation is independently associated with brain network dysfunction in Alzheimer's disease ', Molecular Psychiatry, vol. 28, no. 3 . https://doi.org/10.1038/s41380-022-01878-zTest

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Psychiatry and Mental health, Cross-Sectional Studies, Neuroinflammatory Diseases, Brain/metabolism, Humans, Alzheimer Disease/metabolism, Cognitive Dysfunction/metabolism, Amyloid beta-Peptides/metabolism, Positron-Emission Tomography/methods, Molecular Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945c69de6b909d9cb4585070a99b192aTest
https://doi.org/10.1038/s41380-022-01878-zTest

المؤلفون: Casper Skjærbæk, Eva Schaeffer, Per Borghammer, Nathalie Van Den Berge, Tatyana D. Fedorova, Katrine B. Andersen, Jacob Horsager, Nicola Pavese, David J. Brooks, Daniela Berg, Karoline Knudsen

المصدر: Knudsen, K, Fedorova, T D, Horsager, J, Andersen, K B, Skjærbæk, C, Berg, D, Schaeffer, E, Brooks, D J, Pavese, N, Van Den Berge, N & Borghammer, P 2021, ' Asymmetric Dopaminergic Dysfunction in Brain-First versus Body-First Parkinson's Disease Subtypes ', Journal of Parkinson's Disease, vol. 11, no. 4, pp. 1677-1687 . https://doi.org/10.3233/JPD-212761Test

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Parkinson's disease, Dopamine, PROGRESSION, REM Sleep Behavior Disorder, Binding ratio, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Internal medicine, medicine, Humans, dopaminergic dysfunction, In patient, SCREENING QUESTIONNAIRE, Nigrostriatal degeneration, Tomography, Emission-Computed, Single-Photon, Dopamine Plasma Membrane Transport Proteins, business.industry, Putamen, Dopaminergic, Brain, Parkinson Disease, medicine.disease, PATHOLOGY, 030104 developmental biology, Endocrinology, SLEEP BEHAVIOR DISORDER, alpha-Synuclein, Sleep behavior, Neurology (clinical), Brainstem, business, brain- and body-first, asymmetry, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ab5bb40bc7fad9531656be8be43eb7Test
https://doi.org/10.3233/jpd-212761Test

المؤلفون: Olav M. Andersen, Nikolaj Bøgh, Anne M. Landau, Gro G. Pløen, Anne Mette G. Jensen, Giulia Monti, Benedicte P. Ulhøi, Jens R. Nyengaard, Kirsten R. Jacobsen, Margarita M. Jørgensen, Ida E. Holm, Marianne L. Kristensen, Aage Kristian O. Alstrup, Esben S.S. Hansen, Charlotte E. Teunissen, Laura Breidenbach, Mathias Droescher, Ying Liu, Hanne S. Pedersen, Henrik Callesen, Yonglun Luo, Lars Bolund, David J. Brooks, Christoffer Laustsen, Scott A. Small, Lars F. Mikkelsen, Charlotte B. Sørensen

المساهمون: Clinical chemistry, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Neuroinfection & -inflammation

المصدر: Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell reports. Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016Test/j.xcrm.2022.100740
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell Reports Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016Test/j.xcrm.2022.100740
Cell Reports Medicine, 3(9):100740. Cell Press

مصطلحات موضوعية: Alzheimer Disease/genetics, Haploinsufficiency/genetics, Amyloid beta-Peptides, Swine, SORLA, Membrane Transport Proteins, large animal model, Haploinsufficiency, Alzheimer's disease, General Biochemistry, Genetics and Molecular Biology, Swine, Miniature/metabolism, Alzheimer Disease, retromer-dependent endosomal recycling, SORL1, Amyloid beta-Peptides/genetics, Swine, Miniature, genome editing, Humans, Animals, Membrane Transport Proteins/genetics, LDL-Receptor Related Proteins/genetics, CRISPR-Cas9, LDL-Receptor Related Proteins, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692217e27d26c70f47e5caa412c77719Test
https://vbn.aau.dk/da/publications/871f36d7-57e4-414a-9919-50f1b6541ce5Test

المؤلفون: Ashwin V. Venkataraman, Ayla Mansur, Gaia Rizzo, Courtney Bishop, Yvonne Lewis, Ece Kocagoncu, Anne Lingford-Hughes, Mickael Huiban, Jan Passchier, James B. Rowe, Hideo Tsukada, David J. Brooks, Laurent Martarello, Robert A. Comley, Laigao Chen, Adam J. Schwarz, Richard Hargreaves, Roger N. Gunn, Eugenii A. Rabiner, Paul M. Matthews

المساهمون: National Institute for Health Research, UK DRI Ltd

المصدر: Venkataraman, A V, Mansur, A, Rizzo, G, Bishop, C, Lewis, Y, Kocagoncu, E, Lingford-Hughes, A, Huiban, M, Passchier, J, Rowe, J B, Tsukada, H, Brooks, D J, Martarello, L, Comley, R A, Chen, L, Schwarz, A J, Hargreaves, R, Gunn, R N, Rabiner, E A & Matthews, P M 2022, ' Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease ', Science Translational Medicine, vol. 14, no. 658, eabk1051 . https://doi.org/10.1126/scitranslmed.abk1051Test

مصطلحات موضوعية: IN-VIVO EVALUATION, Science & Technology, Brain, Cell Biology, General Medicine, Research & Experimental Medicine, 06 Biological Sciences, Magnetic Resonance Imaging, ATROPHY, Mitochondria, POSITRON-EMISSION-TOMOGRAPHY, Medicine, Research & Experimental, Alzheimer Disease, Cerebrovascular Circulation, Positron-Emission Tomography, SIGMA(1), Humans, OXIDATIVE STRESS, LIGAND, Life Sciences & Biomedicine, RECEPTOR-BINDING, SA4503, Biomarkers, 11 Medical and Health Sciences, AMYLOID DEPOSITION

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f1dff4aaab7fcdad74b5dfc66d7a81Test
https://doi.org/10.1126/scitranslmed.abk1051Test

المؤلفون: Anthony E, Lang, Andrew D, Siderowf, Eric A, Macklin, Werner, Poewe, David J, Brooks, Hubert H, Fernandez, Olivier, Rascol, Nir, Giladi, Fabrizio, Stocchi, Caroline M, Tanner, Ronald B, Postuma, David K, Simon, Eduardo, Tolosa, Brit, Mollenhauer, Jesse M, Cedarbaum, Kyle, Fraser, James, Xiao, Karleyton C, Evans, Danielle L, Graham, Inbal, Sapir, Jennifer, Inra, R Matthew, Hutchison, Minhua, Yang, Tara, Fox, Samantha, Budd Haeberlein, Tien, Dam, Laurice, Yang

المصدر: Lang, A E, Siderowf, A D, Macklin, E A, Poewe, W, Brooks, D J, Fernandez, H H, Rascol, O, Giladi, N, Stocchi, F, Tanner, C M, Postuma, R B, Simon, D K, Tolosa, E, Mollenhauer, B, Cedarbaum, J M, Fraser, K, Xiao, J, Evans, K C, Graham, D L, Sapir, I, Inra, J, Hutchison, R M, Yang, M, Fox, T, Budd Haeberlein, S, Dam, T & SPARK Investigators 2022, ' Trial of Cinpanemab in Early Parkinson's Disease ', The New England Journal of Medicine, vol. 387, no. 5, pp. 408-420 . https://doi.org/10.1056/NEJMoa2203395Test

مصطلحات موضوعية: Antiparkinson Agents, Treatment Outcome, Double-Blind Method, Monoclonal, alpha-Synuclein, Antibodies, Monoclonal, Humans, Parkinson Disease, General Medicine, Antibodies, Monoclonal, Humanized, Humanized, Antibodies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b50a6abc4d9ecccdef2d7c021fbbee6Test
https://pubmed.ncbi.nlm.nih.gov/35921450Test

المؤلفون: Katrine B, Andersen, Allan K, Hansen, Karoline, Knudsen, Anna Christina, Schacht, Malene F, Damholdt, David J, Brooks, Per, Borghammer

المصدر: Nuclear medicine and biology.

مصطلحات موضوعية: Healthy Aging, Glucose, Fluorodeoxyglucose F18, Positron-Emission Tomography, Brain, Humans, Aged, Glycoproteins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::e6f732fc3dfa3864adc944d2d9ce17b5Test
https://pubmed.ncbi.nlm.nih.gov/35820300Test

المؤلفون: Hilmar P. Sigurdsson, Alison J. Yarnall, Brook Galna, Sue Lord, Lisa Alcock, Rachael A. Lawson, Sean J. Colloby, Michael J. Firbank, John‐Paul Taylor, Nicola Pavese, David J. Brooks, John T. O'Brien, David J. Burn, Lynn Rochester

المساهمون: Sigurdsson, Hilmar P [0000-0002-0624-065X], Yarnall, Alison J [0000-0002-3126-9163], Galna, Brook [0000-0002-5890-1894], Alcock, Lisa [0000-0002-8364-9803], Lawson, Rachael A [0000-0003-2608-8285], Firbank, Michael J [0000-0002-9536-0185], Taylor, John-Paul [0000-0001-7958-6558], Pavese, Nicola [0000-0002-6801-6194], Brooks, David J [0000-0003-2602-2518], O'Brien, John T [0000-0002-0837-5080], Rochester, Lynn [0000-0001-5774-9272], Apollo - University of Cambridge Repository

المصدر: Sigurdsson, H P, Yarnall, A J, Galna, B, Lord, S, Alcock, L, Lawson, R A, Colloby, S J, Firbank, M J, Taylor, J-P, Pavese, N, Brooks, D J, O'Brien, J T, Burn, D J & Rochester, L 2022, ' Gait-Related Metabolic Covariance Networks at Rest in Parkinson's Disease ', Movement Disorders, vol. 37, no. 6, pp. 1222-1234 . https://doi.org/10.1002/mds.28977Test

مصطلحات موضوعية: Parkinson's disease, Parkinson Disease, gait, multivariate covariance networks, Magnetic Resonance Imaging, nervous system diseases, Levodopa, PET, Glucose, Neurology, [18F]-2-fluoro-2-deoxyglucose, Quality of Life, Humans, Neurology (clinical), [ F]-2-fluoro-2-deoxyglucose, health care economics and organizations

وصف الملف: application/pdf; text/xml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8a94c7e440dd621e5ed1c11aa30587Test

المؤلفون: Kristina Bacher Svendsen, Alex Iranzo, Nicola Pavese, Dolores Vilas, David J. Brooks, Eduardo Tolosa, Alicia Garrido, Morten Gersel Stokholm, Marit Otto, Arne Møller, Kristian Stær, Mónica Serradell, Per Borghammer, Joan Santamaria, Karen Østergaard, Carles Gaig

المصدر: Stær, K, Iranzo, A, Stokholm, M G, Østergaard, K, Serradell, M, Otto, M, Svendsen, K B, Garrido, A, Vilas, D, Santamaria, J, Møller, A, Gaig, C, Brooks, D J, Borghammer, P, Tolosa, E & Pavese, N 2020, ' Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder ', Parkinsonism & Related Disorders, vol. 81, pp. 89-93 . https://doi.org/10.1016Test/j.parkreldis.2020.10.014

مصطلحات موضوعية: Male, 0301 basic medicine, Parkinson's disease, Substantia nigra, REM Sleep Behavior Disorder, REM sleep behavior disorder, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Substantia Innominata, medicine, Humans, Cognitive Dysfunction, Donepezil, Carbon Radioisotopes, Neuroinflammation, Aged, Cerebral Cortex, Inflammation, business.industry, Substantia innominata, Middle Aged, Isoquinolines, Mental Status and Dementia Tests, medicine.disease, Acetylcholinesterase, Cortex (botany), 030104 developmental biology, Neurology, chemistry, Positron-Emission Tomography, Cholinergic, Female, Cholinesterase Inhibitors, Microglia, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a4ee8ab93f9a2856d261984fb1f930Test
https://doi.org/10.1016Test/j.parkreldis.2020.10.014

المؤلفون: Rachael A Lawson, Seyed Ehsan Saffari, David J. Brooks, Zheyu Xu, Kirstie N. Anderson, Nicola Pavese, K. Ray Chaudhuri

المصدر: Xu, Z, Anderson, K N, Saffari, S E, Lawson, R A, Chaudhuri, K R, Brooks, D & Pavese, N 2021, ' Progression of sleep disturbances in Parkinson's disease : a 5-year longitudinal study ', Journal of Neurology, vol. 268, no. 1, pp. 312-320 . https://doi.org/10.1007/s00415-020-10140-xTest
Journal of Neurology

مصطلحات موضوعية: Sleep Wake Disorders, Pediatrics, medicine.medical_specialty, Insomnia, Neurology, Parkinson's disease, Excessive daytime sleepiness, REM Sleep Behavior Disorder, REM sleep behavior disorder, RBD, EDS, 03 medical and health sciences, PPMI, 0302 clinical medicine, DISORDER SCREENING QUESTIONNAIRE, QUALITY-OF-LIFE, Humans, BEHAVIOR DISORDER, Medicine, Longitudinal Studies, 030212 general & internal medicine, Sleep disorder, Original Communication, business.industry, Epworth Sleepiness Scale, Parkinson Disease, medicine.disease, Sleep in non-human animals, DYSFUNCTION, EVOLUTION, PREVALENCE, EXCESSIVE DAYTIME SLEEPINESS, Parkinson’s disease, EARLY-STAGE, Neurology (clinical), medicine.symptom, Sleep, NONMOTOR SYMPTOMS, business, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34b78919ca0a5379e48b273c65b102aTest
https://doi.org/10.1007/s00415-020-10140-xTest