المؤلفون: Katharina Domschke, Mirnesa Muminovic Umihanic, Alma Bravo Mehmedbasic, N. Kravić, Caroline M. Nievergelt, Miro Jakovljević, Elma Feric Bojic, Osman Sinanović, Sabina Kucukalic, Shpend Haxhibeqiri, Angelika Erhardt, Bodo Warrings, Blerina Hoxha, Aferdita Goci Uka, Emina Sabic Dzananovic, Valdete Haxhibeqiri, Jürgen Deckert, Ferid Agani, Nenad Jakšić, Alma Dzubur-Kulenovic, Branka Aukst-Margetić, Romana Babić, Damir Marjanović, Nada Bozina, Esmina Avdibegović, Ana Cima Franc, Heike Weber, Abdulah Kucukalic, Marko Pavlović, Dragan Babić, Adam X. Maihofer

المصدر: Journal of Neural Transmission. 129:661-674

مصطلحات موضوعية: Coping (psychology), medicine.medical_specialty, Neurology, Emotions, Genome-wide association study, Logistic regression, behavioral disciplines and activities, Stress Disorders, Post-Traumatic, Risk Factors, Adaptation, Psychological, mental disorders, Humans, Medicine, ddc:610, Europe, Eastern, Association (psychology), Biological Psychiatry, business.industry, Hypervigilance, CAPS, Coping style, Life events, PTSD, Polygenic risk score, Psychiatry and Mental health, Cohort, Neurology (clinical), medicine.symptom, business, Psychopathology, Clinical psychology

الوصف: Objectives Posttraumatic stress disorder (PTSD) is triggered by extremely stressful environmental events and characterized by high emotional distress, re-experiencing of trauma, avoidance and hypervigilance. The present study uses polygenic risk scores (PRS) derived from the UK Biobank (UKBB) mega-cohort analysis as part of the PGC PTSD GWAS effort to determine the heritable basis of PTSD in the South Eastern Europe (SEE)-PTSD cohort. We further analyzed the relation between PRS and additional disease-related variables, such as number and intensity of life events, coping, sex and age at war on PTSD and CAPS as outcome variables. Methods Association of PRS, number and intensity of life events, coping, sex and age on PTSD were calculated using logistic regression in a total of 321 subjects with current and remitted PTSD and 337 controls previously subjected to traumatic events but not having PTSD. In addition, PRS and other disease-related variables were tested for association with PTSD symptom severity, measured by the Clinician Administrated PTSD Scale (CAPS) by liner regression. To assess the relationship between the main outcomes PTSD diagnosis and symptom severity, each of the examined variables was adjusted for all other PTSD related variables. Results The categorical analysis showed significant polygenic risk in patients with remitted PTSD and the total sample, whereas no effects were found on symptom severity. Intensity of life events as well as the individual coping style were significantly associated with PTSD diagnosis in both current and remitted cases. The dimensional analyses showed as association of war-related frequency of trauma with symptom severity, whereas the intensity of trauma yielded significant results independently of trauma timing in current PTSD. Conclusions The present PRS application in the SEE-PTSD cohort confirms modest but significant polygenic risk for PTSD diagnosis. Environmental factors, mainly the intensity of traumatic life events and negative coping strategies, yielded associations with PTSD both categorically and dimensionally with more significant p-values. This suggests that, at least in the present cohort of war-related trauma, the association of environmental factors and current individual coping strategies with PTSD psychopathology was stronger than the polygenic risk.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32267aa08236b8c2005d02ad428fe98Test
https://doi.org/10.1007/s00702-021-02446-5Test

المؤلفون: Tea Petrović, Amrita Vijay, Frano Vučković, Irena Trbojević-Akmačić, Benjamin J. Ollivere, Damir Marjanović, Tamer Bego, Besim Prnjavorac, Lovorka Đerek, Alemka Markotić, Ivica Lukšić, Ivana Jurin, Ana M. Valdes, Irzal Hadžibegović, Gordan Lauc

المصدر: EBioMedicine
Volume 81

مصطلحات موضوعية: Male, Adolescent, Bisecting GlcNAc, IgG glycosylation, BIOMEDICINA I ZDRAVSTVO. Javno zdravstvo i zdravstvena zaštita. Javno zdravstvo, General Biochemistry, Genetics and Molecular Biology, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Human Genetics, Genomics and Proteomics, Polysaccharides, Humans, Longitudinal Studies, bisecting GlcNAc, COVID-19, galactosylation, molecular epidemiology, SARS-CoV-2, Aged, BIOMEDICINE AND HEALTHCARE. Public Health and Health Care. Public Health, General Medicine, Middle Aged, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Infectology, Observational Studies as Topic, Immunoglobulin G, Galactosylation, Molecular epidemiology, Female, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Infektologija, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Genetika, genomika i proteomika čovjeka

الوصف: Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a respiratory illness named coronavirus disease 2019 (COVID-19), one of the main global health problems since 2019. Glycans attached to the Fc portion of immunoglobulin G (IgG) are important modulators of IgG effector functions. The Fc region binds to different receptors on the surface of various immune cells, dictating the type of immune response. Here, we performed a large longitudinal study to determine whether the severity and duration of COVID-19 are associated with altered IgG glycosylation. Methods: Using ultra-high- performance liquid chromatography analysis of released glycans, we analyzed the composition of the total IgG N- glycome longitudinally during COVID-19 from four independent cohorts. We analyzed 77 severe COVID-19 cases from the HR1 cohort (74% males, median age 72, age IQR 25-80) ; 31 severe cases in the HR2 cohort (77% males, median age 64, age IQR 41-86), 18 mild COVID-19 cases from the UK cohort (17% males, median age 50, age IQR 26-71) and 28 mild cases from the BiH cohort (71% males, median age 60, age IQR 12-78). Findings: Multiple statistically significant changes in IgG glycome composition were observed during severe COVID-19. The most statistically significant changes included increased agalactosylation of IgG (meta-analysis 95% CI [0.03, 0.07], adjusted meta-analysis P=

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ac9003733e1eb60305310c26d1bdc8Test
https://doi.org/10.1016/j.ebiom.2022.104101Test

المؤلفون: Tamer Bego, Neven Meseldžić, Besim Prnjavorac, Lejla Prnjavorac, Damir Marjanović, Rui Azevedo, Edgar Pinto, Mary Duro, Cristina Couto, Agostinho Almeida

المساهمون: Repositório Científico do Instituto Politécnico do Porto

المصدر: Journal of Trace Elements in Medicine and Biology. 74:127055

مصطلحات موضوعية: SARS-CoV-2, SARS-CoV-2 infection, Mg, COVID-19, COVID-19 severity, Fe, Severity of Illness Index, Biochemistry, Antioxidants, Trace Elements, Inorganic Chemistry, Zn, Humans, Molecular Medicine, Cu, Se

الوصف: Caused by the new SARS-CoV-2 coronavirus, COVID-19 (coronavirus disease 2019) evolves with clinical symptoms that vary widely in severity, from mild symptoms to critical conditions, which can even result in the patient’s death. A critical aspect related to an individual response to SARS-CoV-2 infection is the competence of the immune system, and it is well known that several trace elements are essential for an adequate immune response and have anti-inflammatory and antioxidant properties that are of particular importance in fighting infection. Thus, it is widely accepted that adequate trace element status can reduce the risk of SARS-CoV-2 infection and disease severity. In this study, we evaluated the serum levels of Cu, Zn, Se, Fe, I and Mg in pa- tients (n = 210) with clinical conditions of different severity (“mild”, “moderate”, “severe” and “exitus letalis”, i. e., patients who eventually died). The results showed significant differences between the four groups for Cu, Zn, Se and Fe, in particular a significant trend of Zn and Se serum levels to be decreased and Cu to be increased with the severity of symptoms. For Mg and I, no differences were observed, but I levels were shown to be increased in all groups.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8831d5493051e55a0159ee05968d0193Test
https://doi.org/10.1016/j.jtemb.2022.127055Test

المؤلفون: Jasmina Čakar, Amela Pilav, Damir Marjanović, Mirela Džehverović, Serkan Dogan, Negra Hadžić Metjahić, Maruška Vidovič

المصدر: HOMO. 70:129-137

مصطلحات موضوعية: Bosnia and Herzegovina, Rural Population, education.field_of_study, Bosnian, Slovenia, Population, Genetic Variation, Zoology, White People, language.human_language, Forensic science, Genetics, Population, Geography, Gene Frequency, Sample size determination, Anthropology, Genetic variation, language, Str loci, Humans, Statistical analysis, education, Microsatellite Repeats

الوصف: This study was conducted to confirm preliminary anthropological research indicating the specificity of isolated Selška Valley populations and implement clear mapping of genetic distances between neighboring populations and similar "inland island" populations from the region. The sample consisted of 86 unrelated individuals born in the Selška Valley from the lowland villages (Bukovica, Ševlje, Dolenja Vas, Selca, Železniki and Zali Log) and the mountain villages (Podlonk, Prtovč, Spodnje Danje, Zgornja Sorica and Spodnja Sorica). The for mentioned 15 STR loci (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, vWA, D8S1179, TPOX and FGA) were analyzed and statistical analysis was applied to determine population-genetics and forensic parameters. The frequencies of 15 STR loci from isolated populations of Slovenian villages, Slovenia, Bosnian mountain villages and Bosnia and Herzegovina were analyzed to calculate genetic distances between them. Our results confirmed a similar genetic pattern between the Selška Valley mountain villages and Slovenian general population as well as Bosnian mountain villages and general Bosnian population. Even if the sample size was relatively small and examined populations were geographically isolated, observed genetic variation within the whole population was relatively high and comparable with neighboring populations. Additional analysis proved that the Selška Valley population is genetically closest to the Slovenian and Austrian populations. On the other hand, comparison with similarly patterned populations confirmed that this population could be recognized as "inland island" population in genetic terms.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5a9f4a69ac887b58b86e9fe597ee1dTest
https://doi.org/10.1127/homo/2019/1036Test

المؤلفون: Nijaz Tihic, Aida Kustura, Visnja Mrdjen, Maja Ostojić, Sead Jazic, Lana Salihefendić, Nihad Fejzic, Mirsada Hukić, Rijad Konjhodzic, Sanjin Musa, Toni Eterović, Damir Marjanović, Sejla Goletic, Maja Travar, Teufik Goletić, Adis Softic

المصدر: Bosnian Journal of Basic Medical Sciences (2021)
Bosnian Journal of Basic Medical Sciences

مصطلحات موضوعية: 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Nanopore sequencing, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, Disease cluster, phylogeny, Epidemiology, medicine, Humans, education, Socioeconomics, Bosnia and Herzegovina, education.field_of_study, whole genome sequencing, Viral infections, lcsh:R5-920, Phylogenetic tree, business.industry, SARS-CoV-2, Outbreak, COVID-19, General Medicine, Genealogy, Geography, Phylogenetic Pattern, business, lcsh:Medicine (General), Research Article

الوصف: This is the first report of molecular and epidemiology findings from Bosnia and Herzegovina related to ongoing severe acute respiratory syndrome coronavirus 2 epidemic. Whole genome sequence of four samples from coronavirus disease 2019 (COVID-19) outbreaks was done in two laboratories in Bosnia and Herzegovina (Veterinary Faculty Sarajevo and Alea Genetic Center). All four BiH sequences cluster mainly with European ones (Italy, Austria, France, Sweden, Cyprus, and England). The constructed phylogenetic tree indicates possible multiple independent introduction events. The data presented contribute to a better understanding of COVID-19 in the current reemergence of the disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6a8251967f55f06792c4028c90e192Test
https://www.bjbms.org/ojs/index.php/bjbms/article/view/5381Test

المؤلفون: Osman Sinanović, Dragan Babić, Dusko Rudan, Mirnesa Muminovic Umihanic, Valdete Haxhibeqiri, Ana Cima Franc, Romana Babić, Sabina Kucukalic, Blerina Hoxha, Valdete Topçiu-Shufta, Damir Marjanović, Christiane Wolf, Emina Šabić Džananović, Bodo Warrings, Aferdita Goci Uka, Elma Feric Bojic, Nada Božina, N. Kravić, Christiane Ziegler, Miro Jakovljević, Marko Pavlović, Shpend Haxhibeqiri, Alma Dzubur Kulenovic, Alma Bravo Mehmedbasic, Abdulah Kucukalic, Jürgen Deckert, Ferid Agani, Katharina Domschke, Nenad Jakšić, Esmina Avdibegović, Branka Aukst Margetić

المصدر: Psychiatria Danubina
Volume 31
Issue 2

مصطلحات موضوعية: Male, Oncology, medicine.medical_specialty, war trauma, PTSD, COMT, IL6, gene polymorphism, Single-nucleotide polymorphism, Catechol O-Methyltransferase, behavioral disciplines and activities, Stress Disorders, Post-Traumatic, 03 medical and health sciences, 0302 clinical medicine, Polymorphism (computer science), Internal medicine, mental disorders, Genotype, medicine, Humans, Europe, Eastern, Allele, Alleles, Depression (differential diagnoses), Mini-international neuropsychiatric interview, Interleukin-6, business.industry, General Medicine, Armed Conflicts, Middle Aged, 030227 psychiatry, Psychiatry and Mental health, Female, Gene polymorphism, business, rs4680

الوصف: Background: Posttraumatic stress disorder (PTSD) is a disorder that occurs in some people who have experienced a severe traumatic event. Several genetic studies suggest that gene encoding proteins of catechol O-methyl-transferase (COMT) may be relevant for the pathogenesis of PTSD. Some researchers suggested that the elevation of interleukin-6 (IL6) correlates with major depression and PTSD. The aim of this study was to investigate whether the single nucleotide polymorphisms COMT rs4680 (Val158Met) and IL6 rs1800795 are associated with PTSD and contribute to the severity of PTSD symptoms. Subjects and methods: This study comprised 747 participants that experienced war between 1991 and 1999 in the South Eastern Europe conflicts. COMT rs4680 (Val158Met) and IL6 rs1800795 genotypes were determined in 719 participants (369 with and 350 without PTSD). The Mini International Neuropsychiatric Interview (M.I.N.I.), the Clinician Administrated PTSD Scale (CAPS) questionnaire and the Brief Symptom Inventory (BSI) were used for data collection. Results: Regarding the COMT gene polymorphism, the results of the regression analyses for BSI total score were significant in the lifetime PTSD group in the dominant (P=0.031) and the additive allelic model (P=0.047). Regarding the IL6 gene, a significant difference was found for the recessive model predicting CAPS total score in the lifetime PTSD group (P=0.048), and indicated an association between the C allele and higher CAPS scores. n the allelic, genotypic and rezessive model, the results for BSI total score were significant in the lifetime PTSD group (P=0.033, P=0.028 and P=0.009), suggesting a correlation of the C allele with higher BSI scores Conclusion: Although our nominally significant results did not withstand correction for multiple tests they may support a relevance of the COMT (Val158Met) and IL6 rs1800795 polymorphism for aspects of PTSD in war traumatized individuals.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3e90f4cab88f8023faa61ea9f43dfdTest
https://doi.org/10.24869/psyd.2019.241Test

المؤلفون: Adna Ašić, Ramona Salazar, Damir Marjanović, Dragan Primorac, Serkan Dogan, Wolfgang Höppner, Niels Storm

المصدر: Molecular Biology Reports
Volume 48
Issue 6

مصطلحات موضوعية: Adult, Male, Genotype, Factor V Asp2194Gly, Buccal swab, Population, Bosnia and Herzegovina, Factor V Leiden, Factor V Met2120Thr, Rare Factor V variants, Thrombophilia, Biology, Polymorphism, Single Nucleotide, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Human Genetics, Genomics and Proteomics, Prevalence, Genetics, medicine, Humans, education, Molecular Biology, Genotyping, education.field_of_study, Factor V, Genetic Variation, DNA, General Medicine, medicine.disease, Healthy Volunteers, Minor allele frequency, Population study, Female, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Genetika, genomika i proteomika čovjeka, Microsatellite Repeats

الوصف: Background: Human gene F5, encoding coagulation factor V, was previously reported to be highly polymorphic. Apart from FV Leiden, an array of other rare variants has been detected in clinical practice and associated with thrombotic events, especially in cases when patient’s phenotype and FV Leiden genotype were not in agreement.Methods and Results: In this study, the prevalence of 17 rare F5 variants has been studied on a sample of 130 healthy adult individuals from the general Bosnian-Herzegovinian population. DNA was isolated from buccal swab samples, while genotyping was performed using MALDI-TOF MS method. The results have shown that Asp2194Gly and Met2120Thr are polymorphic in the study population with minor allele frequencies of 0.077 and 0.073, respectively. Additionally, these two variants were found to be mutually exclusive with FV Leiden and none of them was positively associated with participants’ family history of cardiovascular or cerebrovascular diseases.Conclusions: While the obtained results are in agreement with previously reported data for the general Caucasian populations, it is worth noting that only two rare F5 variants were detected in the study population, albeit at considerable frequencies. Still, scientific information on rare F5 variants is rather scarce and further studies aiming to assess functional importance of these variants, as well as their role as prothrombotic factors are necessary.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ee6c0348a552bccfc529dd6d2422f0Test
https://www.bib.irb.hr/1250739Test

المؤلفون: Alessandro Raveane, Shahlo Turdikulova, Donata Luiselli, Pongsakorn Wangkumhang, Marta E. Alarcón-Riquelme, Francesco Montinaro, Guido Alberto Gnecchi-Ruscone, Damir Marjanović, Mait Metspalu, Sarabjit S. Mastana, Oleg Balanovsky, Alessandro Achilli, Antonio Torroni, Lejla Kovacevic, L. A. Atramentova, Anna Olivieri, Maria Fernanda Lima-Costa, Linda Ongaro, Cristian Capelli, Toomas Kivisild, Bernardo L. Horta, Nédio Mabunda, Marilia O. Scliar, Roy J. King, Etienne Patin, Kristiina Tambets, Garrett Hellenthal, Mauricio Lima Barreto, Celia A. May, Miguel Gonzalez-Santos, Andreja Leskovac, Andrés Moreno-Estrada, Eduardo Tarazona-Santos, Alexandre C. Pereira, Rodrigo Flores, Anastasia Kouvatsi, Luca Pagani, Stefania Sarno, Elena Balanovska, Ornella Semino, Davide Marnetto

المساهمون: Ongaro L., Scliar M.O., Flores R., Raveane A., Marnetto D., Sarno S., Gnecchi-Ruscone G.A., Alarcon-Riquelme M.E., Patin E., Wangkumhang P., Hellenthal G., Gonzalez-Santos M., King R.J., Kouvatsi A., Balanovsky O., Balanovska E., Atramentova L., Turdikulova S., Mastana S., Marjanovic D., Mulahasanovic L., Leskovac A., Lima-Costa M.F., Pereira A.C., Barreto M.L., Horta B.L., Mabunda N., May C.A., Moreno-Estrada A., Achilli A., Olivieri A., Semino O., Tambets K., Kivisild T., Luiselli D., Torroni A., Capelli C., Tarazona-Santos E., Metspalu M., Pagani L., Montinaro F., Institute of Genomics [Tartu, Estonia], University of Tartu, Universidade de São Paulo = University of São Paulo (USP), Dipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani' = Department of Biology and Biotechnology [Univ di Pavia] (DBB UNIPV), Università degli Studi di Pavia = University of Pavia (UNIPV), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, Centre for Genomics and Oncological Reearch (GENYO), Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), University College of London [London] (UCL), University of Oxford, Stanford University School of Medicine [CA, USA], Aristotle University of Thessaloniki, Vavilov Institute of General Genetics, Russian Academy of Sciences [Moscow] (RAS), V.N. Karazin Kharkiv National University (KhNU), Institute of Bioorganic Chemistry [Tashkent, Uzbekistan], Academy of Sciences of Republic of Uzbekistan, Loughborough University, International Burch University [Sarajevo], University of Belgrade [Belgrade], Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Universidade Federal da Bahia (UFBA), Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Instituto Nacional de Saude [Maputo, Mozambique] (INS), University of Leicester, National Laboratory of Genomics for Biodiversity (LANGEBIO), Centro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Dipartimento di Biologia e Biotecnologie 'L. Spallanzani', Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), University of Bologna/Università di Bologna, Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG), University of São Paulo (USP), Dipartimento di Biologia e Biotecnologie ‘Lazzaro Spallanzani’, University of Pavia, University of Pavia, BIGEA, Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum – University of Bologna, Bologna, Italy, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), University of Oxford [Oxford], Fundação Oswaldo Cruz (FIOCRUZ), Universidade de São Paulo (USP), University of Bologna

المصدر: Current Biology
Current Biology-CB
Current Biology-CB, 2019, 29 (23), pp.3974-3986.e4. ⟨10.1016/j.cub.2019.09.076⟩
Current Biology-CB, Elsevier, 2019, 29 (23), pp.3974-3986.e4. ⟨10.1016/j.cub.2019.09.076⟩

مصطلحات موضوعية: 0301 basic medicine, admixture history of the America, Human genetic variation, Colonialism, Atlantic Slave Trade, Gene flow, 0302 clinical medicine, Colonization, European colonization, African Continental Ancestry Group, 0303 health sciences, Genome, Middle East, Geography, Caribbean Region, Genetic structure, Ethnology, General Agricultural and Biological Sciences, Atlantic slave trade, Human, MESH: Caribbean Region, Gene Flow, American Native Continental Ancestry Group, Demographic history, European Continental Ancestry Group, Black People, Biology, General Biochemistry, Genetics and Molecular Biology, White People, 03 medical and health sciences, sex-biased admixture, Humans, admixture history of the Americas, MESH: Gene Flow, MESH: Genome, Human, American Indian or Alaska Native, 030304 developmental biology, MESH: Central America, MESH: Humans, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Central America, North America, South America, Genome, Human, MESH: South America, MESH: North America, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, 030217 neurology & neurosurgery

الوصف: The complexity of the admixture dynamics that shaped American populations is unveiled by Ongaro et al., where genetic data for more than 12,000 individuals from the continents are investigated. This study evaluates the dramatic impact of events after the colonial era, revealing a spatial and temporal heterogeneity and mirroring historical records. © 2019 Elsevier Ltd The human genetic diversity of the Americas has been affected by several events of gene flow that have continued since the colonial era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here, we compiled a genome-wide dataset of ∼12,000 individuals from twelve American countries and ∼6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected (1) the genetic structure, (2) the admixture profile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East, and to specific regions of Africa. © 2019 Elsevier Ltd Preprint version of the article: "The genomic impact of European colonization of the Americas", posted June 28, 2019 on bioRxiv. Article is now published in Current Biology doi: [dx.doi.org/10.1016/j.cub.2019.09.076]. Published version on this repository: [http://vinar.vin.bg.ac.rs/handle/123456789/8654Test].

وصف الملف: STAMPA; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7305870a47c570d1863fdacb68c22310Test
https://hdl.handle.net/10668/14702Test

المؤلفون: Azra Hasic, Lejla Mehinovic, Damir Marjanović, Mirsada Hukić, Larisa Bešić, Mirza Kozaric, Amina Kurtovic-Kozaric, Adna Ašić

المصدر: Environmental Research. 156:665-673

مصطلحات موضوعية: 0301 basic medicine, DNA damage, Chemical toxicity, Depleted uranium, Exposure, Radioactivity, in vivo and in vitro studies, 010501 environmental sciences, Pharmacology, 01 natural sciences, Biochemistry, Epigenesis, Genetic, 03 medical and health sciences, In vivo, Animals, Humans, Epigenetics, 0105 earth and related environmental sciences, General Environmental Science, Chromosome Aberrations, Chemistry, Radiochemistry, DNA Methylation, In vitro, 030104 developmental biology, Micronucleus test, Toxicity, Uranium, Environmental Pollutants, DNA Damage

الوصف: The main aim of this review is to summarize and discuss the current state of knowledge on chemical toxicity and radioactivity of depleted uranium (DU) and their effect on living systems and cell lines. This was done by presenting a summary of previous investigations conducted on different mammalian body systems and cell cultures in terms of potential changes caused by either chemical toxicity or radioactivity of DU. In addition, the authors aimed to point out the limitations of those studies and possible future directions. The majority of both in vitro and in vivo studies performed using animal models regarding possible effects caused by acute or chronic DU exposure has been reviewed. Furthermore, exposure time and dose, DU particle solubility, and uranium isotopes as factors affecting the extent of DU effects have been discussed. Special attention has been dedicated to chromosomal aberrations, DNA damage and DNA breaks, as well as micronuclei formation and epigenetic changes, as DU has recently been considered a possible causative factor of all these processes. Therefore, this approach might represent a novel area of study of DU-related irradiation effects on health. Since different studies offer contradictory results, the main aim of this review is to summarize and briefly discuss previously obtained results in order to identify the current opinion on DU toxicity and radioactivity effects in relation to exposure type and duration, as well as DU properties.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf25264c9618929dd47156075a7367f0Test
https://doi.org/10.1016/j.envres.2017.04.032Test

المؤلفون: Naris Pojskić, Anesa Ahatović, Amela Pilav, Mirela Džehverović, Jasmina Čakar, Damir Marjanović

المصدر: Croatian Medical Journal
Volume 58
Issue 3

مصطلحات موضوعية: Adult, 0301 basic medicine, Forensic Science, Genotype, Turkey, Bosnian, Population, Locus (genetics), Biology, 03 medical and health sciences, Gene Frequency, Humans, Allele, education, Allele frequency, Bosnia and Herzegovina, Genetics, education.field_of_study, Polymorphism, Genetic, DNA, General Medicine, DNA Fingerprinting, language.human_language, 030104 developmental biology, Genetic distance, DNA profiling, Austria, language, Microsatellite, Microsatellite Repeats

الوصف: Aim To determine newest the most accurate allele frequencies for 15 short tandem repeat (STR) loci in the Bosnian and Herzegovinian population, calculate statistical parameters, and compare them with the relevant data for seven neighboring populations. Methods Genomic DNA was obtained from buccal swabs of 1000 unrelated individuals from all regions of Bosnia and Herzegovina. Genotyping was performed using PowerPlex® 16 System to obtain allele frequencies for 15 polymorphic STR loci including D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, vWA, D8S1179, TPOX, and FGA. The calculated allele frequencies were also compared with the data from neighboring populations. Results The highest detected value of polymorphism information content (PIC) was detected at the PentaE locus, whereas the lowest value was detected at the TPOX locus. The power of discrimination (PD) values had similar distribution, with Penta E showing the highest PD of 0.9788. While D18S51 had the highest value of power of exclusion (PE), the lowest PE value was detected at the TPOX locus. Conclusion Upon comparison of Bosnian and Herzegovinian population data with those of seven neighboring populations, the highest allele frequency differentiation was noticed between Bosnian and Herzegovinian and Turkish population at 5 loci, the most informative of which was Penta E. The neighbor-joining dendrogram constructed on the basis of genetic distance showed grouping of Slovenian, Austrian, Hungarian, and Croatian populations. Bosnian and Herzegovinian population was between the mentioned cluster and Serbian population. To determine more accurate distribution of allelic frequencies and forensic parameters, our study included 1000 unrelated individuals from all regions of Bosnia and Herzegovina, and our findings demonstrated the applicability of these markers in both forensics and future population genetic studies.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53770cb8a10c6827c538a3bc4ca56fe0Test
https://doi.org/10.3325/cmj.2017.58.250Test