Moderate Levels of N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Increased Risks of Total and Ischemic Strokes among Japanese
| العنوان: | Moderate Levels of N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Increased Risks of Total and Ischemic Strokes among Japanese |
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| المؤلفون: | Ebihara, Kenji, Yamagishi, Kazumasa, Umesawa, Mitsumasa, Muraki, Isao, Cui, Renzhe, Imano, Hironori, Kubota, Yasuhiko, Hayama-Terada, Mina, Shimizu, Yuji, Ohira, Tetsuya, Sankai, Tomoko, Okada, Takeo, Kitamura, Akihiko, Kiyama, Masahiko, Iso, Hiroyasu |
| المصدر: | Journal of Atherosclerosis and Thrombosis |
| بيانات النشر: | Japan Atherosclerosis Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Epidemiology, Follow-up study, Biomarker, Peptide Fragments, Brain Ischemia, Stroke, Japan, Natriuretic Peptide, Brain, Humans, Original Article, cardiovascular diseases, Risk factor, hormones, hormone substitutes, and hormone antagonists, Biomarkers |
| الوصف: | Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP), frequently used as a biochemical marker for detecting and monitoring heart failure, is also a risk marker for development of coronary heart disease and total stroke. However, studies that explore subtypes of ischemic stroke with regard to NT-proBNP are scarce. Here, we examined NT-proBNP and its impact upon subtypes of ischemic stroke (lacunar stroke, large-artery occlusive stroke and embolic stroke) among Japanese. Methods: We measured NT-proBNP and categorized 4,393 participants of the Circulatory Risk in Communities Study into four groups (< 55, 55–124, 125–399, and ≥ 400 pg/ml). We used a multivariable Cox proportional hazards model to examine association with risks of stroke and subtypes. Results: During 4.7 years of follow-up, we identified 50 strokes, including 35 ischemic (15 lacunar, 6 largeartery occlusive, 10 embolic strokes) and 14 hemorrhagic strokes. NT-proBNP was associated with stroke risk: the multivariable hazard ratio of total strokes was 7.29 (2.82–18.9) for the highest and 2.78 (1.25–6.16) for the second highest NT-proBNP groups compared with the lowest group. The respective hazard ratios for the highest NT-proBNP group were 9.37 (3.14–28.0) for ischemic stroke and 6.81 (1.11–41.7) for lacunar stroke. Further adjustment for atrial fibrillation did not attenuate these associations. The associations were similarly observed for large-artery occlusive and embolic strokes. Conclusion: We found that even moderate serum levels of NT-proBNP were associated with the risk of total and ischemic strokes among Japanese whose NT-proBNP levels were relatively low compared with Westerners. |
| اللغة: | English |
| تدمد: | 1880-3873 1340-3478 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::f3c385d31bbdd8788a1958af1e1da1efTest http://europepmc.org/articles/PMC7458784Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........f3c385d31bbdd8788a1958af1e1da1ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18803873 13403478 |
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