المؤلفون: Kristian F. Hanssen, James A. Scardo, Jeremy Y. Yu, Christopher E. Aston, Judith Shary, Alison Nankervis, Satish K. Garg, Timothy J. Lyons, Clare B. Kelly, Alicia J. Jenkins, Carol L. Wagner, Samar M. Hammad, Misti J. Leyva

المصدر: Nutrients, Vol 12, Iss 2048, p 2048 (2020)
Kelly, C B, Wagner, C L, Shary, J R, Leyva, M J, Yu, J Y, Jenkins, A J, Nankervis, A J, Hanssen, K F, Garg, S K, Scardo, J A, Hammad, S M, Aston, C E & Lyons, T J 2020, ' Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes ', Nutrients, vol. 12, no. 7, 2048 . https://doi.org/10.3390/nu12072048Test
Nutrients
Volume 12
Issue 7

مصطلحات موضوعية: 0301 basic medicine, 1,25-dihydroxyvitamin D, Vitamin D-binding protein, type 1 diabetes, Pregnancy in Diabetics, vitamin D, Vitamin D binding protein, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, vitamin D binding protein, Medicine, Longitudinal Studies, Vitamin D, Nutrition and Dietetics, Vitamin D-Binding Protein, 25-hydroxyvitamin D, Type 1 diabetes, Pregnancy Trimester, Second, Gestation, Female, pregnancy, lcsh:Nutrition. Foods and food supply, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, lcsh:TX341-641, Article, vitamin D deficiency, Preeclampsia, preeclampsia, Young Adult, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Diabetes mellitus, Internal medicine, Vitamin D and neurology, Humans, business.industry, Vitamin D Deficiency, medicine.disease, Pregnancy Trimester, First, Diabetes Mellitus, Type 1, 030104 developmental biology, Endocrinology, business, Biomarkers, Food Science

الوصف: The risk for preeclampsia (PE) is enhanced ~4-fold by the presence of maternal type 1 diabetes (T1DM). Vitamin D is essential for healthy pregnancy. We assessed the total, bioavailable, and free concentrations of plasma 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and vitamin D binding protein (VDBP) at ~12, ~22, and ~32 weeks&rsquo
gestation (&ldquo
Visits&rdquo
(V) 1, 2, and 3, respectively) in 23 T1DM women who developed PE, 24 who remained normotensive, and 19 non-diabetic, normotensive women (reference controls). 25(OH)D deficiency was more frequent in diabetic than non-diabetic women (69% vs. 22%, p <
0.05), but no measure of 25(OH)D predicted PE. By contrast, higher 1,25(OH)2D concentrations at V2 (total, bioavailable, and free: p <
0.01) and V3 (bioavailable: p <
0.05
free: p <
0.01), lower concentrations of VDBP at V3 (p <
0.05), and elevated ratios of 1,25(OH)2D/VDBP (V2, V3: p <
0.01) and 1,25(OH)2D/25(OH)D (V3, p <
0.05) were all associated with PE, and significance persisted in multivariate analyses. In summary, in women with T1DM, concentrations of 1,25(OH)2D were higher, and VDBP lower, in the second and third trimesters in women who later developed PE than in those who did not. 1,25(OH)2D may serve as a new marker for PE risk and could be implicated in pathogenesis.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f119bcf1f3e9ca2022cff10fc5dd28Test
https://www.mdpi.com/2072-6643/12/7/2048Test

المؤلفون: James A. Scardo, Christopher E. Aston, Kristian F. Hanssen, Alicia J. Jenkins, Satish K. Garg, Michelle B. Hookham, Samar M. Hammad, Alison Nankervis, Timothy J. Lyons, Clare B. Kelly, M. Kathryn Menard, Jeremy Y. Yu

المصدر: Diabetes Care

مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, Pregnancy in Diabetics, Renal function, 030209 endocrinology & metabolism, Blood Pressure, Preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Diabetes mellitus, Internal Medicine, medicine, Humans, education, Subclinical infection, Advanced and Specialized Nursing, education.field_of_study, Type 1 diabetes, e-Letters: Comments and Responses, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics, medicine.disease, 3. Good health, Pregnancy Trimester, First, Blood pressure, Diabetes Mellitus, Type 1, Kidney Diseases, Female, business

الوصف: We thank Foussard et al. (1) for their interest in our study (2). We agree that caution is required when identifying predictive markers of clinical interest in pregnant women with diabetes with regard to preeclampsia (PE). Accurate estimation of renal function is critical for the care of pregnant patients. Alper et al. (3) highlighted the limitations of currently available formulas for accurately predicting the glomerular filtration rate (GFR) in patients with PE. Our study focused on markers of renal function early in pregnancy prior to the clinical onset of PE. We studied a population with type 1 diabetes, thus at high risk of …

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe5876329bbe9c7161660211c1dd716Test
https://pubmed.ncbi.nlm.nih.gov/29784705Test

المؤلفون: Mei Du, Michael Centola, Timothy J. Lyons, Satish K. Garg, Samar M. Hammad, Arpita Basu, Mingyuan Wu, Christopher E. Aston, Kristian F. Hanssen, Dongxu Fu, Alicia J. Jenkins, James A. Scardo

المصدر: Diabetes Care

مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030204 cardiovascular system & hematology, Gastroenterology, Preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Longitudinal Studies, Prospective Studies, Endothelial dysfunction, Prospective cohort study, Pathophysiology/Complications, Original Research, Advanced and Specialized Nursing, Type 1 diabetes, 030219 obstetrics & reproductive medicine, biology, business.industry, C-reactive protein, medicine.disease, 3. Good health, Chemokine CXCL10, Interleukin 1 Receptor Antagonist Protein, Endocrinology, C-Reactive Protein, Diabetes Mellitus, Type 1, biology.protein, Female, Age of onset, business, E-Selectin

الوصف: OBJECTIVE Inflammation and endothelial dysfunction have been associated with the immunobiology of preeclampsia (PE), a significant cause of adverse pregnancy outcomes. The prevalence of PE is elevated several fold in the presence of maternal type 1 diabetes mellitus (T1DM). Although cross-sectional studies of pregnancies among women without diabetes have shown altered inflammatory markers in the presence of PE, longitudinal studies of diabetic women are lacking. In maternal serum samples, we examined the temporal associations of markers of inflammation with the subsequent development of PE in women with T1DM. RESEARCH DESIGN AND METHODS We conducted longitudinal analyses of serum C-reactive protein (CRP), adhesion molecules, and cytokines during the first (mean ± SD, 12.2 ± 1.9 weeks), second (21.6 ± 1.5 weeks), and third (31.5 ± 1.7 weeks) trimesters of pregnancy (visits 1–3, respectively). All study visits took place before the onset of PE. Covariates were BMI, HbA1c, age of onset, duration of diabetes, and mean arterial pressure. RESULTS In women with T1DM who developed PE versus those who remained normotensive, CRP tended to be higher at visits 1 (P = 0.07) and 2 (P = 0.06) and was significantly higher at visit 3 (P < 0.05); soluble E-selectin and interferon-γ–inducible protein-10 (IP-10) were significantly higher at visit 3; interleukin-1 receptor antagonist (IL-1ra) and eotaxin were higher and lower, respectively, at visit 2 (all P < 0.05). These conclusions persisted following adjustment for covariates. CONCLUSIONS In pregnant women with T1DM, elevated CRP, soluble E-selectin, IL-1ra, and IP-10 and lower eotaxin were associated with subsequent PE. The role of inflammatory factors as markers and potential mechanisms of the high prevalence of PE in T1DM merits further investigation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072f345d20ad922ef0e96f5a4b11110fTest
http://europepmc.org/articles/PMC3687330Test

المؤلفون: Yongxin Yu, Kristian F. Hanssen, Hanne Scholz, Timothy J. Lyons, Joshua J. Wang, Tore Henriksen, M. K. Menard, K. May, Azar Dashti, K. Lu, Christopher E. Aston, John R. Stanley, Alicia J. Jenkins, Alison Nankervis, Samar M. Hammad, Torun Clausen, Bjorg Lorentzen, Jian Xing Ma, J. C. Scardo, Sarah X. Zhang, Satish K. Garg

المصدر: Diabetologia. 52:160-168

مصطلحات موضوعية: Adult, Placental growth factor, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Angiogenesis Inhibitors, Receptors, Cell Surface, Biology, Preeclampsia, Pre-Eclampsia, Antigens, CD, Pregnancy, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Nerve Growth Factors, Eye Proteins, Prospective cohort study, Serpins, reproductive and urinary physiology, Glycated Hemoglobin, Type 1 diabetes, Vascular Endothelial Growth Factor Receptor-1, Eclampsia, Endoglin, Membrane Proteins, medicine.disease, Pregnancy Complications, Diabetes Mellitus, Type 1, Endocrinology, Growth Hormone, Female, Tyrosine kinase

الوصف: Elevated anti-angiogenic factors such as soluble fms-like tyrosine kinase 1 (sFlt1), a soluble form of vascular endothelial growth factor receptor, and endoglin, a co-receptor for TGFbeta1, confer high risk of pre-eclampsia in healthy pregnant women. In this multicentre prospective study, we determined levels of these and related factors in pregnant women with type 1 diabetes, a condition associated with a fourfold increase in pre-eclampsia.Maternal serum sFlt1, endoglin, placental growth factor (PlGF) and pigment epithelial derived factor were measured in 151 type 1 diabetic and 24 healthy non-diabetic women at each trimester and at term.Approximately 22% of the diabetic women developed pre-eclampsia, primarily after their third trimester visit. In women with pre-eclampsia (diabetic pre-eclampsia, n = 26) vs those without hypertensive complications (diabetic normotensive, n = 95), significant changes in angiogenic factors were observed, predominantly in the early third trimester and prior to clinical manifestation of pre-eclampsia. Serum sFlt1 levels were increased approximately twofold in type 1 diabetic pre-eclampsia vs type 1 diabetic normotensive women at the third trimester visit (p0.05) and the normal rise of PlGF during pregnancy was blunted (p0.05). Among type 1 diabetic women, third trimester sFlt1 and PlGF were inversely related (r(2) = 42%, p0.0001). Endoglin levels were increased significantly in the diabetic group as a whole vs the non-diabetic group (p0.0001).Higher sFlt1 levels, a blunted PlGF rise and an elevated sFlt1/PlGF ratio are predictive of pre-eclampsia in pregnant women with type 1 diabetes. Elevated endoglin levels in women with type 1 diabetes may confer a predisposition to pre-eclampsia and may contribute to the high incidence of pre-eclampsia in this patient group.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8cd35c81ffded9c8728f952c5559ceTest
https://doi.org/10.1007/s00125-008-1182-xTest

المؤلفون: Kristian F. Hanssen, Samar M. Hammad, James A. Scardo, Bjørg Lorentzen, Christopher E. Aston, M. Kathryn Menard, Satish K. Garg, Timothy J. Lyons, Alison Nankervis, Arpita Basu, Tore Henriksen, Alicia J. Jenkins, Jeremy Y. Yu

مصطلحات موضوعية: Adult, Risk, medicine.medical_specialty, Antioxidant, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Pregnancy in Diabetics, chemistry.chemical_element, Zinc, medicine.disease_cause, Article, Preeclampsia, Cohort Studies, Endocrinology, Pre-Eclampsia, Pregnancy, Internal medicine, Prenatal Diagnosis, medicine, Humans, Longitudinal Studies, Prospective Studies, Type 1 diabetes, Nutrition and Dietetics, Chemistry, Norway, Cholesterol, HDL, Australia, medicine.disease, United States, Oxidative Stress, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Early Diagnosis, Gestation, Female, Selenium, Oxidative stress, Biomarkers, Copper

الوصف: Preeclampsia (PE) affects approximately 5% of all pregnancies, but is increased several-fold in women with pre-gestational type 1 diabetes mellitus (T1DM). Increased oxidative stress and altered maternal plasma trace elements that modulate the antioxidant system have been implicated in PE. In non-diabetic women, increased plasma copper and iron and decreased manganese, selenium, and zinc have been associated with PE in cross-sectional studies. In a longitudinal study, we hypothesized that plasma levels of trace elements differ between T1DM women with vs. without subsequent PE. Samples were collected during the first (gestation 12.2 ± 1.9 weeks, [mean ± SD]), second (21.6 ± 1.5 weeks), and third (31.5 ± 1.7 weeks) trimesters of pregnancy, all before the onset of PE. We compared 23 T1DM women who subsequently developed PE with 24 T1DM women who remained normotensive; and we included 19 non-diabetic (non-DM) normotensive pregnant women as reference controls. Trace elements were measured using inductively coupled plasma mass spectroscopy. In T1DM women with subsequent PE vs normotensive, only plasma zinc was significantly higher at the first trimester, while copper:zinc and copper:high-density lipoprotein cholesterol ratios were higher throughout gestation (all P < .05). These findings persisted after adjustment for covariates. Higher copper:zinc ratios may contribute to oxidative stress in T1DM women who develop PE. Ratios of pro- to anti-oxidant factors may predict risk for PE in diabetic pregnancies more effectively than individual trace element levels.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d02611104a942900266512676eaa1aTest
https://europepmc.org/articles/PMC4442033Test/

المؤلفون: Christopher E. Aston, Samar M. Hammad, Alison Nankervis, Torun Clausen, Kristian F. Hanssen, Tore Henriksen, James A. Scardo, Arpita Basu, Bjørg Lorentzen, Petar Alaupovic, M. Kathryn Menard, Hanne Scholz, Timothy J. Lyons, Azar Dashti, John R. Stanley, Satish K. Garg, Mingyuan Wu, Alicia J. Jenkins, Yongxin Yu

المصدر: The Journal of clinical endocrinology and metabolism. 97(5)

مصطلحات موضوعية: Adult, medicine.medical_specialty, Apolipoprotein B, Endocrinology, Diabetes and Metabolism, Lipoproteins, Clinical Biochemistry, Pregnancy in Diabetics, Context (language use), Biochemistry, Preeclampsia, Endocrinology, Pre-Eclampsia, Pregnancy, Internal medicine, Diabetes mellitus, medicine, Humans, Endocrine Research, Prospective Studies, Prospective cohort study, Glycated Hemoglobin, Type 1 diabetes, biology, business.industry, Biochemistry (medical), nutritional and metabolic diseases, medicine.disease, Cholesterol, Cross-Sectional Studies, Diabetes Mellitus, Type 1, biology.protein, Female, business, Dyslipidemia, Lipoprotein

الوصف: In nondiabetic pregnancy, cross-sectional studies have shown associations between maternal dyslipidemia and preeclampsia (PE). In type 1 diabetes mellitus (T1DM), the prevalence of PE is increased 4-fold, but prospective associations with plasma lipoproteins are unknown.The aim of this study was to define lipoprotein-related markers and potential mechanisms for PE in T1DM.We conducted a multicenter prospective study in T1DM pregnancy.We studied 118 T1DM women (26 developed PE, 92 remained normotensive). Subjects were studied at three visits before PE onset [12.2 ± 1.9, 21.6 ± 1.5, and 31.5 ± 1.7 wk gestation (means ± SD)] and at term (37.6 ± 2.0 wk). Nondiabetic normotensive pregnant women (n = 21) were included for reference.Conventional lipid profiles, lipoprotein subclasses [defined by size (nuclear magnetic resonance) and by apolipoprotein content], serum apolipoproteins (ApoAI, ApoB, and ApoCIII), and lipolysis (ApoCIII ratio) were measured in T1DM women with and without subsequent PE.In women with vs. without subsequent PE, at the first and/or second study visits: low-density lipoprotein (LDL)-cholesterol, particle concentrations of total LDL and large (but not small) LDL, serum ApoB, and ApoB:ApoAI ratio were all increased (P0.05); peripheral lipoprotein lipolysis was decreased (P0.01). These early differences remained significant in covariate analysis (glycated hemoglobin, actual prandial status, gravidity, body mass index, and diabetes duration) but were not present at the third study visit. High-density lipoprotein and very low-density lipoprotein subclasses did not differ between groups before PE onset.Early in pregnancy, increased cholesterol-rich lipoproteins and an index suggesting decreased peripheral lipolysis were associated with subsequent PE in T1DM women. Background maternal lipoprotein characteristics, perhaps masked by effects of late pregnancy, may influence PE risk.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a8ef2bb9851e642af76c60348bbbe6Test
https://pubmed.ncbi.nlm.nih.gov/22438226Test