Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination
| العنوان: | Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination |
|---|---|
| المؤلفون: | De La Fuente, Alerie Guzman, Lange, Simona, Silva, Maria Elena, Gonzalez, Ginez A., Tempfer, Herbert, van Wijngaarden, Peter, Zhao, Chao, Di Canio, Ludovica, Trost, Andrea, Bieler, Lara, Zaunmair, Pia, Rotheneichner, Peter, O’Sullivan, Anna, Couillard-Despres, Sebastien, Errea, Oihana, Mäe, Maarja A., Andrae, Johanna, He, Liqun, Keller, Annika, Bátiz, Luis F., Betsholtz, Christer, Aigner, Ludwig, Franklin, Robin J.M., Rivera, Francisco J. |
| المساهمون: | University of Zurich, Rivera, Francisco J |
| المصدر: | De La Fuente, A G, Lange, S, Silva, M E, Gonzalez, G A, Tempfer, H, van Wijngaarden, P, Zhao, C, Di Canio, L, Trost, A, Bieler, L, Zaunmair, P, Rotheneichner, P, O'Sullivan, A, Couillard-Despres, S, Errea, O, Mäe, M A, Andrae, J, He, L, Keller, A, Bátiz, L F, Betsholtz, C, Aigner, L, Franklin, R J M & Rivera, F J 2017, ' Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination ', Cell Reports, vol. 20, no. 8, pp. 1755-1764 . https://doi.org/10.1016/j.celrep.2017.08.007Test Cell Reports, Vol 20, Iss 8, Pp 1755-1764 (2017) Cell Reports |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Central Nervous System, neurovascular niche, 610 Medicine & health, Lama2, pericytes, Nerve Regeneration/physiology, 10180 Clinic for Neurosurgery, Mice, 1300 General Biochemistry, Genetics and Molecular Biology, Report, Pericytes/cytology, Animals, Cell Differentiation/physiology, Humans, lcsh:QH301-705.5, Cells, Cultured, Central Nervous System/cytology, oligodendrocyte progenitor cell, Cell Differentiation, Oligodendroglia/cytology, Nerve Regeneration, Oligodendroglia, remyelination, lcsh:Biology (General), nervous system, Demyelinating Diseases |
| الوصف: | Summary The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfbret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration. Graphical Abstract Highlights • CNS-resident PCs react to demyelination and are found close to differentiating OPCs • PC-deficient mice show delayed OPC differentiation during CNS remyelination • PC-conditioned medium accelerates OPC differentiation and enhances remyelination • PC-derived LAMA2 induces OPC differentiation Following toxin-induced demyelination in PC-deficient mice and using a number of in vitro approaches, Guzman de la Fuente et al. show that CNS pericytes (PCs) respond to demyelination and, through Lama2 secretion, stimulate oligodendrocyte progenitor cell differentiation during remyelination. These findings extend PC function beyond vascular homeostasis toward regeneration. |
| وصف الملف: | application/pdf; Pericytes_Stimulate_Oligodendrocyte_Progenitor_Cell_Differentiation_during_CNS_Remyelination.pdf - application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3e8cc323b0fe2407e2a5a303ef6fe219Test https://pure.qub.ac.uk/en/publications/pericytes-stimulate-oligodendrocyte-progenitor-cell-differentiation-during-cns-remyelinationTest(c397b1f7-39e4-4045-be9f-f369606da79c).html |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....3e8cc323b0fe2407e2a5a303ef6fe219 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |