المؤلفون: Rüdiger Kornberger, Benjamin Berger, Jasper Dingemanse

المصدر: European Neuropsychopharmacology. 51:90-104

مصطلحات موضوعية: Pyrrolidines, Visual analogue scale, Citalopram, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Pharmacokinetics, mental disorders, Humans, Medicine, Single-Blind Method, Pharmacology (medical), Biological Psychiatry, business.industry, Imidazoles, Antagonist, Healthy Volunteers, Orexin receptor, 030227 psychiatry, Psychiatry and Mental health, Neurology, Tolerability, Pharmacodynamics, Orexin Receptor Antagonists, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug, Blood sampling

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9f9245670717330f545cd9619d54e6Test
https://doi.org/10.1016/j.euroneuro.2021.05.005Test

المؤلفون: Fabio Arturo Iannotti, Roberta Imperatore, Luigia Cristino, Serena Boccella, Raffaele Capasso, Fabiana Piscitelli, Monica Iannotta, Maria De Risi, Elvira De Leonibus, Vincenzo Di Marzo, Paolo de Girolamo, Nicola Forte, Sabatino Maione, Lea Tunisi, Alba Clara Fernández-Rilo

المساهمون: Forte, N., Boccella, S., Tunisi, L., Fernandez-Rilo, A. C., Imperatore, R., Iannotti, F. A., De Risi, M., Iannotta, M., Piscitelli, F., Capasso, R., De Girolamo, P., De Leonibus, E., Maione, S., Di Marzo, V., Cristino, L.

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature communications 12 (2021). doi:10.1038/s41467-021-26388-4
info:cnr-pdr/source/autori:Forte N.; Boccella S.; Tunisi L.; Fernandez-Rilo A.C.; Imperatore R.; Iannotti F.A.; De Risi M.; Iannotta M.; Piscitelli F.; Capasso R.; De Girolamo P.; De Leonibus E.; Maione S.; Di Marzo V.; Cristino L./titolo:Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice/doi:10.1038%2Fs41467-021-26388-4/rivista:Nature communications/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:12
Nature Communications

مصطلحات موضوعية: Male, Cannabinoid receptor, Neurogenesis, Memory, Episodic, Science, General Physics and Astronomy, Hippocampus, Mice, Obese, Hippocampal formation, Biology, General Biochemistry, Genetics and Molecular Biology, Article, neuroscience, Orexin-A, Mice, Endocrinology, Hippocampu, Receptor, Cannabinoid, CB1, Orexin Receptors, mental disorders, Animals, Humans, metabolic disorders, Obesity, endocannabinoids, Episodic memory, Endocannabinoid, Neurons, Orexins, Multidisciplinary, Neuronal Plasticity, Animal, Dentate gyrus, digestive, oral, and skin physiology, General Chemistry, Neuron, Orexin Receptor, Endocannabinoid system, nervous system, Orexin, Female, Neurogenesi, Neuroscience, Human, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a24d23cc7a5a38d30f7916ae7e129bTest
https://doaj.org/article/cc36a8296dcb45b6b3ee6a982be5d94eTest

المؤلفون: Mirunalini Ravichandran, Subhiksha Subramanian

المصدر: Fundamental & Clinical Pharmacology. 36:72-80

مصطلحات موضوعية: Pharmacology, Nervous system, Orexins, Drug discovery, Neuropeptides, digestive, oral, and skin physiology, Optogenetics, Biology, Orexin receptor, Receptors, G-Protein-Coupled, medicine.anatomical_structure, nervous system, Orexin Receptors, Sleep Initiation and Maintenance Disorders, mental disorders, medicine, Drug approval, Humans, Pharmacology (medical), Receptor, Neuroscience, hormones, hormone substitutes, and hormone antagonists, G protein-coupled receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3940a00d6a047f0695b9a1c4ed9a95caTest
https://doi.org/10.1111/fcp.12723Test

المؤلفون: Anna Sieben, F. Thomas Wunderlich, Dong Kong, Xing Xiao, Peter Kloppenburg, André Kleinridders, Thomas E. Scammell, Gagik Yeghiazaryan, Simon Hess, A. Christine Hausen, Paul Klemm, Bradford B. Lowell, Jens C. Brüning, Kamal Rahmouni, Donald A. Morgan

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications

مصطلحات موضوعية: Blood Glucose, medicine.medical_specialty, Median raphe nucleus, Lateral hypothalamus, Science, General Physics and Astronomy, Diet, High-Fat, Serotonergic, Neural circuits, General Biochemistry, Genetics and Molecular Biology, Article, Mice, Nerve Fibers, Dorsal raphe nucleus, Adipose Tissue, Brown, Orexin Receptors, Internal medicine, mental disorders, medicine, Animals, Homeostasis, Glucose homeostasis, Humans, Obesity, Serotonin Plasma Membrane Transport Proteins, Orexins, Multidisciplinary, Raphe, Chemistry, Diabetes, digestive, oral, and skin physiology, General Chemistry, Orexin receptor, Orexin, Glucose, Endocrinology, Liver, nervous system, Hypothalamic Area, Lateral, Raphe Nuclei, Insulin Resistance, Fat metabolism, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes, Serotonergic Neurons, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39018121014cacedc640165017f559f8Test
https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6Test

المؤلفون: Margaret Moline, Makoto Okuya, Takehiro Taninaga, Nakao Iwata, Kenzo Muramoto, Michinori Koebis, Ikuo Nomura, Maika Nishida, Taro Kishi, Naoki Kubota, Kenji Sakuma

المصدر: Neuropsychopharmacology Reports

مصطلحات موضوعية: insomnia, Network Meta-Analysis, Lemborexant, Physical dependence, Review Article, Pharmacology, Orexin Receptors, Sleep Initiation and Maintenance Disorders, Insomnia, medicine, network meta‐analysis, Humans, Pharmacology (medical), Adverse effect, Review Articles, Orexins, evidence‐based medicine, business.industry, Suvorexant, Orexin receptor, Orexin, Discontinuation, Psychiatry and Mental health, Clinical Psychology, orexin, Orexin Receptor Antagonists, medicine.symptom, business, lemborexant

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19e5bc56db988660805f4504e7c3a7dTest
http://europepmc.org/articles/PMC8698673Test

المؤلفون: Giorgio Bergamini, Michel A. Steiner, Catherine Roch, Martine Clozel

المصدر: Psychopharmacology

مصطلحات موضوعية: Pyrrolidines, Insomnia, Daridorexant, Allosteric regulation, Physical dependence, Review, Pharmacology, Doras, Nonclinical, Orexin Receptors, Sleep Initiation and Maintenance Disorders, Dual orexin receptor antagonist, medicine, Humans, Receptor, biology, Mechanism (biology), business.industry, Sleep architecture, Imidazoles, Antagonist, biology.organism_classification, Orexin receptor, Orexin, Orexin Receptor Antagonists, medicine.symptom, Sleep, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98223dcb1d64e58042db5b10ea52358eTest
https://doi.org/10.1007/s00213-021-05954-0Test

المؤلفون: Clemens Muehlan, Gernot Klein, Benjamin Berger, Jasper Dingemanse

المصدر: Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 6, Pp 2132-2138 (2021)

مصطلحات موضوعية: Male, 030213 general clinical medicine, medicine.medical_specialty, Pyrrolidines, medicine.medical_treatment, Cmax, Renal function, RM1-950, 030226 pharmacology & pharmacy, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Humans, Renal Insufficiency, General Pharmacology, Toxicology and Pharmaceutics, Dialysis, Aged, Aged, 80 and over, business.industry, Brief Report, Research, General Neuroscience, Imidazoles, Antagonist, General Medicine, Middle Aged, Orexin receptor, Confidence interval, Tolerability, Female, Orexin Receptor Antagonists, Brief Reports, Therapeutics. Pharmacology, Public aspects of medicine, RA1-1270, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5fcf73eae9c6fc7202883b54aefa7bTest
https://doi.org/10.1111/cts.13079Test

المؤلفون: Clemens Muehlan, Urs Duthaler, Stephane Delahaye, Jasper Dingemanse, Benjamin Berger, Stephan Krähenbühl, Giancarlo Sabattini

المصدر: Clinical Pharmacokinetics. 60:1349-1360

مصطلحات موضوعية: Liver Cirrhosis, medicine.medical_specialty, Pyrrolidines, Cirrhosis, Metabolite, 030226 pharmacology & pharmacy, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Adverse effect, Pharmacology, Volume of distribution, business.industry, Liver Diseases, Imidazoles, Antagonist, medicine.disease, Orexin receptor, chemistry, Tolerability, Area Under Curve, Orexin Receptor Antagonists, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3436174cb8e7e7c5ce550a461a31e69Test
https://doi.org/10.1007/s40262-021-01028-8Test

المؤلفون: Corey Strickland, Christina Minnick, Michael J. Breslin, Srivanya Tummala, Kaspar Hollenstein, Alexei Brooun, Vanessa L. Rada, Shawn J. Stachel, Beata Zamlynny, Kira A. Armacost, Dawn L. Hall, Li Xiao, Terrence P. McDonald, Chuan Hong, Kern Jeffrey, Scott A. Hollingsworth, Stephen M. Soisson, Julie A. O'Brien, Andrea T. Partridge, Jennifer M. Shipman, Michael T. Rudd, Noel Byrne

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

مصطلحات موضوعية: Agonist, Protein Conformation, alpha-Helical, medicine.drug_class, Science, Genetic Vectors, General Physics and Astronomy, Aminopyridines, Gene Expression, Peptide, Plasma protein binding, Pharmacology, Molecular Dynamics Simulation, General Biochemistry, Genetics and Molecular Biology, Article, G protein-coupled receptors, Cryoelectron microscopy, Orexin Receptors, medicine, Escherichia coli, Humans, Protein Interaction Domains and Motifs, Cloning, Molecular, chemistry.chemical_classification, Sulfonamides, Multidisciplinary, Binding Sites, Chemistry, HEK 293 cells, digestive, oral, and skin physiology, General Chemistry, Azepines, Triazoles, medicine.disease, Small molecule, Orexin receptor, Recombinant Proteins, Orexin, HEK293 Cells, Sleep Aids, Pharmaceutical, Orexin Receptor Antagonists, Protein Conformation, beta-Strand, Peptides, Narcolepsy, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e52de5a726dc2d15e8ae787fb1b0817Test
https://doaj.org/article/71020c0fdeec442e80fbd53a66967a19Test

المؤلفون: Rob Zuiker, Benjamin Berger, Sander Brooks, Muriel Richard, Clemens Muehlan, Jasper Dingemanse

المصدر: CNS Drugs. 34:1253-1266

مصطلحات موضوعية: Adult, Male, Pyrrolidines, Sedation, Pharmacology, Placebo, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Alcohol intoxication, Double-Blind Method, Pharmacokinetics, medicine, Humans, Drug Interactions, Pharmacology (medical), Cross-Over Studies, Ethanol, business.industry, Imidazoles, Antagonist, medicine.disease, Crossover study, Orexin receptor, 030227 psychiatry, Psychiatry and Mental health, Pharmacodynamics, Female, Orexin Receptor Antagonists, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe98b4ca3557e59bdac0932aecd3a3e0Test
https://doi.org/10.1007/s40263-020-00768-8Test