Pegylated interferon plus ribavirin in HIV-infected patients with recurrent hepatitis C after liver transplantation: A prospective cohort study
| العنوان: | Pegylated interferon plus ribavirin in HIV-infected patients with recurrent hepatitis C after liver transplantation: A prospective cohort study |
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| المؤلفون: | Federico Pulido, Ferran Torres, Lluis Castells, Esteban Ribera, Ramon Charco, Carme Baliellas, Pilar Barrera Baena, Rafael Bañares, Isabel Campos Varela, Gonzalo Crespo, MARIA PILAR LUQUE GOMEZ, Montse Tuset, M. Trinidad Serrano Aulló, Manuel Rodriguez, Santos Del Campo, Joan Gavaldà, Pilar Martín-Dávila, Juan González-García, MIGUEL ANGEL GOMEZ BRAVO, Carlos Cervera, Carmen Bernal-Bellido, Moreno-Cuerda Victor, Martin Prieto, MARIA VICTORIA AGUILERA SANCHO-TELLO, Diego Rincon, Alejandro Forner, Montserrat Laguno Centeno, Andrés Valdivieso, Jordi Carratala, Julio Santoyo, Elisa De Lazzari, Laura Llado, Elisa Cordero, Xavier Xiol, Emilio Fábrega |
| المصدر: | JOURNAL OF HEPATOLOGY r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| بيانات النشر: | ELSEVIER SCIENCE BV, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Survival, medicine.medical_treatment, HIV Infections, Hepacivirus, Liver transplantation, medicine.disease_cause, Gastroenterology, Polyethylene Glycols, chemistry.chemical_compound, Model for End-Stage Liver Disease, Pegylated interferon, Recurrence, Prospective Studies, Drug Carriers, Coinfection, virus diseases, Hepatitis C, Middle Aged, Viral Load, Recombinant Proteins, HCV infection, Treatment Outcome, RNA, Viral, Drug Therapy, Combination, Female, Viral load, medicine.drug, Adult, medicine.medical_specialty, Hepatitis C virus, Pegylated-interferon, Alpha interferon, Antiviral Agents, Internal medicine, Ribavirin, medicine, Humans, Hepatology, business.industry, HIV, Interferon-alpha, Hepatitis C, Chronic, medicine.disease, HIV infection, digestive system diseases, Recurrence of hepatitis C, Liver Transplantation, chemistry, Antiviral treatment, Immunology, business, Follow-Up Studies |
| الوصف: | Background & Aims: The aim of this study was to evaluate the results of treatment with pegylated interferon and ribavirin for the recurrence of hepatitis C after liver transplantation in HCV/ HIV-coinfected patients. Methods: This was a prospective, multicentre cohort study, including 78 HCV/HIV-coinfected liver transplant patients who received treatment for recurrent hepatitis C. For comparison, we included 176 matched HCV-monoinfected patients who underwent liver transplantation during the same period of time at the same centres and were treated for recurrent hepatitis C. Results: Antiviral therapy was discontinued prematurely in 56% and 39% (p = 0.016), mainly because of toxicity (22% and 11%, respectively; p = 0.034). Sustained virological response (SVR) was achieved in 21% of the coinfected patients and in 36% of monoinfected patients (p = 0.013). For genotype 1, SVR rates were 10% and 33% (p = 0.002), respectively; no significant differences were observed for the other genotypes. A multivariate analysis based on the whole series identified HIV-coinfection as an independent predictor of lack of SVR (OR, 0.17; 95% CI, 0.06-0.42). Other predictors of SVR were donor age, pretreatment HCV viral load, HCV genotype, and early virological response. SVR was associated with a significant improvement in survival: 5-year survival after antiviral treatment was 79% for HCV/HIV-coinfected patients with SVR vs. 43% for those without (p = 0.02) and 92% vs. 60% in HCV-monoinfected patients (p < 0.001), respectively. Conclusions: The response to pegylated interferon and ribavirin was poorer in HCV/HIV-coinfected liver recipients, particularly those with genotype 1. However, when SVR was achieved, survival of coinfected patients increased significantly. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
| تدمد: | 0168-8278 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205e43b0a421be975216d5d97359ae17Test https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2792Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....205e43b0a421be975216d5d97359ae17 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01688278 |
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