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المؤلفون: Zheng Jian Li, Guodong Chen, Li Tao
المصدر: Drug Discovery Today. 27:196-206
مصطلحات موضوعية: Pharmacology, Protein therapeutics, Protein Conformation, Chemistry, Drug Compounding, Deuterium Exchange Measurement, Proteins, Computational biology, Photochemical Processes, Mass spectrometry, Mass Spectrometry, Stability assessment, Characterization (materials science), Structure-Activity Relationship, Epitope mapping, Drug Development, Drug Discovery, Humans, Hydrogen–deuterium exchange, Higher Order Structure
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae999ccb9e706280083492927b01199Test
https://doi.org/10.1016/j.drudis.2021.09.010Test -
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المؤلفون: Jodi Shaulsky, Andrew C. Good, Roman V. Agafonov, Tobie D. Lee, Christopher G. Nasveschuk, Andrew J. K. Phillips, Joe Sahil Patel, Ryan E. Michael, Hongwei Huang, Scott J. Eron, Mark E. Fitzgerald, Stewart L. Fisher, Ashley A. Hart
المصدر: 'ACS Chemical Biology ', vol: 16, pages: 2228-2243 (2021)
مصطلحات موضوعية: Models, Molecular, Indoles, Protein Conformation, Cell Cycle Proteins, Protein degradation, Biochemistry, Mass Spectrometry, Piperidines, Acetamides, Humans, Molecule, Computer Simulation, Macromolecular docking, Ternary complex, Molecular Structure, Chemistry, Deuterium Exchange Measurement, General Medicine, Combinatorial chemistry, HEK293 Cells, Gene Expression Regulation, Models, Chemical, Docking (molecular), Molecular Medicine, Hydrogen–deuterium exchange, Ternary operation, Linker, Transcription Factors
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cbcbb46e22a554e95dd60b690230ecTest
https://doi.org/10.1021/acschembio.1c00376Test -
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المصدر: ACS Chem Neurosci
مصطلحات موضوعية: Gene isoform, Physiology, Cognitive Neuroscience, Kinetics, Mutant, Peptide, Biochemistry, Article, 03 medical and health sciences, Residue (chemistry), 0302 clinical medicine, Alzheimer Disease, Amyloid precursor protein, Humans, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Amyloid beta-Peptides, biology, Deuterium Exchange Measurement, Cell Biology, General Medicine, Deuterium, Peptide Fragments, In vitro, chemistry, Biophysics, biology.protein, Hydrogen–deuterium exchange, 030217 neurology & neurosurgery, Hydrogen
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b75628e276ac4f16ab8c107ac0905a3Test
https://doi.org/10.1021/acschemneuro.1c00072Test -
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المؤلفون: Julie Ducharme, Vanja Polic, Christopher J. Thibodeaux, Karine Auclair
المصدر: ACS Chemical Biology. 16:882-890
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Allosteric regulation, Hydrogen Deuterium Exchange-Mass Spectrometry, Plasma protein binding, Molecular Dynamics Simulation, Ligands, 01 natural sciences, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Protein structure, Cytochrome P-450 CYP3A, Humans, Structure–activity relationship, Bioconjugation, 010405 organic chemistry, Ligand, Chemistry, Deuterium Exchange Measurement, General Medicine, Deuterium, Small molecule, 0104 chemical sciences, 3. Good health, 030104 developmental biology, Biophysics, Molecular Medicine, Hydrogen–deuterium exchange, Allosteric Site, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0676cc08793fae1577d21f2c72cee82Test
https://doi.org/10.1021/acschembio.1c00084Test -
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المؤلفون: Miklos Guttman, Rick Harkewicz, Kimberly M. Alonge
المصدر: Curr Mol Med
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Ion-mobility spectrometry, Chondroitin Sulfates, Disaccharide, Deuterium Exchange Measurement, General Medicine, Mass spectrometry, Biochemistry, Article, chemistry.chemical_compound, Sulfation, chemistry, Deuterium, Computational chemistry, Humans, Molecular Medicine, Hydrogen–deuterium exchange, Chondroitin sulfate, Sulfate, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e46484e92eefadf3dfb7957fc278ddTest
https://doi.org/10.2174/1566524020666200915110707Test -
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المؤلفون: Alice R Eddershaw, Karl Syson, Paul R. J. Davey, Gregory Hamm, Christopher D. Stubbs, Paul Clarkson, Elizabeth Underwood, Lucy V Edwardes
المصدر: Biochemistry. 59:4775-4786
مصطلحات موضوعية: Models, Molecular, Protein-Arginine N-Methyltransferases, Methyltransferase, Arginine, In Vitro Techniques, Biochemistry, Mass Spectrometry, Substrate Specificity, 03 medical and health sciences, Protein structure, Catalytic Domain, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Enzyme Inhibitors, Protein Structure, Quaternary, Ternary complex, Adaptor Proteins, Signal Transducing, 0303 health sciences, Chemistry, Protein arginine methyltransferase 5, 030302 biochemistry & molecular biology, Deuterium Exchange Measurement, Recombinant Proteins, Kinetics, Biophysics, Hydrogen–deuterium exchange, Steady state (chemistry)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c63875119c271f482688a035fe6bfcTest
https://doi.org/10.1021/acs.biochem.0c00554Test -
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المؤلفون: Cunle Wu, Yves Fortin, Andrea Acel, Marie Parat, Denis L'Abbé, Mélanie Duchesne, Shawn C. Chafe, Jason Baardsnes, Shoukat Dedhar, Mylene Gosselin, John F. Kelly, Anna Robotham, Joey G. Sheff, Anne E.G. Lenferink, Henk van Faassen, Traian Sulea, Félix Malenfant, Paul C. McDonald, Shannon Awrey, Jean Lefebvre, Alex Pelletier
المصدر: mAbs
article-version (VoR) Version of Recordمصطلحات موضوعية: tumor, medicine.drug_class, Immunology, Allosteric regulation, carbonic anhydrase, Hydrogen Deuterium Exchange-Mass Spectrometry, anti-cancer target, Monoclonal antibody, Epitope, antibody-drug conjugate, hydrogen-deuterium, spectrometry, 03 medical and health sciences, 0302 clinical medicine, Report, Catalytic Domain, antibody, medicine, Extracellular, Immunology and Allergy, tumor microenvironment, Humans, mapping, 030304 developmental biology, mass spectrometry, chemistry.chemical_classification, 0303 health sciences, epitope, allostery, exchange, Antibodies, Monoclonal, Deuterium Exchange Measurement, Isothermal titration calorimetry, Deuterium, microenvironment, 3. Good health, hydrogen-deuterium exchange, epitope mapping, Epitope mapping, Enzyme, chemistry, 030220 oncology & carcinogenesis, Biophysics, mass, Hydrogen–deuterium exchange
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5fe5101105353d594f55bce98ca553Test
https://nrc-publications.canada.ca/eng/view/object/?id=b84f2488-1160-40b0-9ea8-e1ed0c1c57e9Test -
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المؤلفون: Kohei Tanaka, Jun Kondo, Masaru Miyagi, Shinko Watanabe, Taro Kishimoto
المصدر: Analytical chemistry. 93(45)
مصطلحات موضوعية: Drug, Chemistry, media_common.quotation_subject, HEK 293 cells, Deuterium Exchange Measurement, Deuterium, Analytical Chemistry, HEK293 Cells, Mechanism of action, Affinity chromatography, Covalent bond, Tandem Mass Spectrometry, medicine, Biophysics, Humans, Hydrogen–deuterium exchange, Chemical stability, Drug Interactions, Histidine, medicine.symptom, media_common, Chromatography, Liquid, Hydrogen
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44b6496dd8cebd387036d2012bc3674Test
https://pubmed.ncbi.nlm.nih.gov/34735131Test -
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المؤلفون: Michael A. Kennedy, Shenyuan Xu
المصدر: Proteins: Structure, Function, and Bioinformatics. 88:1493-1512
مصطلحات موضوعية: Protein Conformation, alpha-Helical, Repetitive Sequences, Amino Acid, Protein Folding, Stereochemistry, Arabidopsis, Molecular Dynamics Simulation, Cyanobacteria, Biochemistry, Pentapeptide repeat, 03 medical and health sciences, Molecular dynamics, chemistry.chemical_compound, Bacterial Proteins, Structural Biology, Group (periodic table), Amide, Animals, Humans, Order (group theory), Protein Interaction Domains and Motifs, Molecular Biology, 030304 developmental biology, 0303 health sciences, Binding Sites, Protein Stability, Hydrogen bond, Protein dynamics, 030302 biochemistry & molecular biology, Deuterium Exchange Measurement, Hydrogen Bonding, chemistry, Thermodynamics, Protein Conformation, beta-Strand, Hydrogen–deuterium exchange, Oligopeptides, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabaf4092fd5f011755d260c78dd3fe9Test
https://doi.org/10.1002/prot.25969Test -
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المؤلفون: Michelle Kuhne, Richard Y.-C. Huang, Vangipuram S. Rangan, Yun Wang, Shrikant Deshpande, Mohan Srinivasan, Guodong Chen
المصدر: Analytical and Bioanalytical Chemistry. 412:1693-1700
مصطلحات موضوعية: medicine.drug_class, 02 engineering and technology, Monoclonal antibody, Major histocompatibility complex, 01 natural sciences, Biochemistry, Mass Spectrometry, Epitope, Analytical Chemistry, Natural killer cell, Electron Transport, medicine, Humans, Amino Acid Sequence, biology, Chemistry, Histocompatibility Antigens Class I, 010401 analytical chemistry, Antibodies, Monoclonal, Deuterium Exchange Measurement, 021001 nanoscience & nanotechnology, NKG2D, 0104 chemical sciences, Electron-transfer dissociation, stomatognathic diseases, medicine.anatomical_structure, Epitope mapping, biology.protein, Biophysics, Hydrogen–deuterium exchange, 0210 nano-technology, Epitope Mapping
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ffddbb3df0d56793789a069d253f87Test
https://doi.org/10.1007/s00216-020-02409-xTest