دورية أكاديمية
Neutrophil to lymphocyte ratio and breast cancer risk: analysis by subtype and potential interactions.
| العنوان: | Neutrophil to lymphocyte ratio and breast cancer risk: analysis by subtype and potential interactions. |
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| المؤلفون: | Gago Dominguez, Manuela, Matabuena, Marcos, Redondo, Carmen M, Patel, Sandip Pravin, Carracedo Álvarez, Ángel, Miranda Ponte, Sara, Martínez, María Elena, Castelao Fernández, José Esteban |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Risk, Menopause, Adult, Breast Neoplasms, Neoplasm Staging, Middle Aged, Lymphocytes, Adolescent, Lymphocyte Count, Neoplasm Grading, Neutrophils, Pregnancy, Humans, Case-Control Studies, estudios de casos y controles, menopausia, estadificación de neoplasias, neoplasias de la mama, recuento de linfocitos, mediana edad, embarazo, adulto, humanos, riesgo, gradación neoplásica, adolescente, linfocitos, neutrófilos, FPGMX, IDIS |
| الوصف: | Multiple studies have found the neutrophil to lymphocyte ratio (NLR) to be associated with adverse breast cancer (BC) prognosis and survival. Very limited data exist on the role of NLR and risk of BC. The BREOGAN study is a population-based case-control study conducted in Galicia, Spain. We examined the WBC- and NLR-BC relationships. The risk of BC increased with increasing levels of neutrophils percentage (NE%) (multivariable OR for the highest category (95% CI) = 2.14 (1.39-3.32), P-trend < 0.001) and of the NLR (multivariable OR for the highest category (95% CI) = 1.93 (1.26-2.97), P-trend < 0.001). Lymphocytes absolute (L#) and percentage (L%) were associated with a decreased risk of BC (multivariable OR for the highest category (95% CI) = 0.54 (0.35-0.83), and 0.51 (0.33-0.79), P-trend = 0.001 and < 0.001, respectively). The NLR-BC association was more pronounced among Luminal A BC (multivariable OR for the highest category (95% CI) = 2.00 (1.17-3.45), P-trend < 0.001), HER2-negative BC (multivariable OR for the highest category (95% CI) = 1.87 (1.16-3.02), P-trend < 0.001), and those with high total cholesterol and low H2O2 levels. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 2045-2322 |
| العلاقة: | https://www.ncbi.nlm.nih.gov/pubmed/32764699Test; http://hdl.handle.net/20.500.11940/16829Test; 41773 |
| DOI: | 10.1038/s41598-020-70077-z |
| الإتاحة: | https://doi.org/20.500.11940/16829Test https://doi.org/10.1038/s41598-020-70077-zTest https://hdl.handle.net/20.500.11940/16829Test https://www.ncbi.nlm.nih.gov/pubmed/32764699Test |
| حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.F699DD31 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-020-70077-z |