المؤلفون: Bianco, Francesco, De Caterina, Raffaele, Chandra, Alvin, Aquila, Iolanda, Claggett, Brian, Johansen, Michelle C, Gonçalves, Alexandra, Norby, Faye L, Cogswell, Rebecca, Soliman, Elsayed Z, Gottesman, Rebecca, Mosley, Thomas, Alonso, Alvaro, Shah, Amil, Solomon, Scott D, Chen, Lin Yee

المساهمون: Bianco, Francesco, De Caterina, Raffaele, Chandra, Alvin, Aquila, Iolanda, Claggett, Brian, Johansen, Michelle C, Gonçalves, Alexandra, Norby, Faye L, Cogswell, Rebecca, Soliman, Elsayed Z, Gottesman, Rebecca, Mosley, Thoma, Alonso, Alvaro, Shah, Amil, Solomon, Scott D, Chen, Lin Yee

مصطلحات موضوعية: 3‐dimensional echocardiography, left atrial function, left atrial stiffne, left atrial strain, subclinical cerebral infarction, Aged, 80 and over, Cerebral Infarction, Cohort Studie, Female, Human, Male, Atrial Appendage, Atrial Fibrillation, Atrial Remodeling, Stroke

الوصف: Background Age-related left atrial (LA) structural and functional abnormalities may be related to subclinical cerebral infarcts (SCIs) and stroke. We evaluated the association of 3-dimensional echocardiographic LA contractility parameters with SCIs and stroke across the spectrum of tertiles of age increment in elderly patients with sinus rhythm, normal ejection fraction, and no history of atrial fibrillation. Methods and Results We enrolled 407 participants (mean age, 76±8 years; 40% men) from ARIC-NCS (Atherosclerosis Risk in Communities Neurocognitive Study) undergoing a brain magnetic resonance imaging and 3-dimensional echocardiographic examinations in 2011 to 2013. The sample was analyzed among age tertiles and subgroups: no cerebral magnetic resonance imaging-detectable infarcts (n=315), magnetic resonance imaging-diagnosed SCIs (n=58), and clinically diagnosed stroke (n=34). The frequency of SCIs significantly increased over age tertiles (P trend 0.023). LA global longitudinal strain-a 3-dimensional echocardiographic index of LA reservoir function-and E/e' divided by LA global longitudinal strain-an index of LA stiffness-worsened across age tertiles (P trend 0.014 and 0.001, respectively), and only in the categories of SCIs (P trend <0.001 and 0.045, respectively) and stroke (P trend 0.001 and 0.011, respectively). LA global longitudinal strain was negatively associated with increased odds of SCIs (P=0.036, P=0.008, and P=0.001, respectively) and strokes (P=0.043, P=0.015, and P=0.001, respectively) over age tertiles, with a significant interaction between age tertiles (interaction P=0.043 and P=0.010, respectively). E/e' divided by LA global longitudinal strain was positively associated with the presence of SCIs (P=0.037, P=0.007, and P=0.001, respectively) and strokes (P=0.045, P=0.007, and P=0.003, respectively) over age tertiles, with a significant interaction only for SCIs (interaction P=0.040) and not for clinical stroke. Conclusions In a large cohort study of elderly patients, among ...

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35491988; info:eu-repo/semantics/altIdentifier/wos/WOS:000789861900021; volume:11; issue:9; firstpage:Art. N° e024292; numberofpages:19; journal:JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE; http://hdl.handle.net/11564/776859Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85129781782

الإتاحة: https://doi.org/10.1161/JAHA.121.024292Test
http://hdl.handle.net/11564/776859Test

المؤلفون: Patti, Giuseppe, Cavallari, Ilaria, Andreotti, Felicita, Calabrò, Paolo, Cirillo, Plinio, Denas, Gentian, Galli, Mattia, Golia, Enrica, Maddaloni, Ernesto, Marcucci, Rossella, Parato, Vito Maurizio, Pengo, Vittorio, Prisco, Domenico, Ricottini, Elisabetta, Renda, Giulia, Santilli, Francesca, Simeone, Paola, De Caterina, Raffaele

المساهمون: Patti, Giuseppe, Cavallari, Ilaria, Andreotti, Felicita, Calabrò, Paolo, Cirillo, Plinio, Denas, Gentian, Galli, Mattia, Golia, Enrica, Maddaloni, Ernesto, Marcucci, Rossella, Parato, Vito Maurizio, Pengo, Vittorio, Prisco, Domenico, Ricottini, Elisabetta, Renda, Giulia, Santilli, Francesca, Simeone, Paola, De Caterina, Raffaele

مصطلحات موضوعية: Blood Coagulation, Cardiovascular Disease, Diabetes Mellitu, Fibrinolytic Agent, Human, Hypoglycemic Agent, Practice Guidelines as Topic, Risk Factor, Secondary Prevention

الوصف: Diabetes mellitus is an important risk factor for a first cardiovascular event and for worse outcomes after a cardiovascular event has occurred. This situation might be caused, at least in part, by the prothrombotic status observed in patients with diabetes. Therefore, contemporary antithrombotic strategies, including more potent agents or drug combinations, might provide greater clinical benefit in patients with diabetes than in those without diabetes. In this Consensus Statement, our Working Group explores the mechanisms of platelet and coagulation activity, the current debate on antiplatelet therapy in primary cardiovascular disease prevention, and the benefit of various antithrombotic approaches in secondary prevention of cardiovascular disease in patients with diabetes. While acknowledging that current data are often derived from underpowered, observational studies or subgroup analyses of larger trials, we propose antithrombotic strategies for patients with diabetes in various cardiovascular settings (primary prevention, stable coronary artery disease, acute coronary syndromes, ischaemic stroke and transient ischaemic attack, peripheral artery disease, atrial fibrillation, and venous thromboembolism). Finally, we summarize the improvements in cardiovascular outcomes observed with the latest glucose-lowering drugs, and on the basis of the available evidence, we expand and integrate current guideline recommendations on antithrombotic strategies in patients with diabetes for both primary and secondary prevention of cardiovascular disease.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30250166; info:eu-repo/semantics/altIdentifier/wos/WOS:000458561600014; volume:16; issue:2; firstpage:113; lastpage:130; numberofpages:18; journal:NATURE REVIEWS. CARDIOLOGY; http://hdl.handle.net/11564/701187Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85053831930; https://www.nature.com/articles/s41569-018-0080-2Test

الإتاحة: https://doi.org/10.1038/s41569-018-0080-2Test
http://hdl.handle.net/11564/701187Test
https://www.nature.com/articles/s41569-018-0080-2Test

المؤلفون: Di Castelnuovo, Augusto, Costanzo, Simona, Antinori, Andrea, Berselli, Nausicaa, Blandi, Lorenzo, Bonaccio, Marialaura, Cauda, Roberto, Gialluisi, Alessandro, Guaraldi, Giovanni, Menicanti, Lorenzo, Mennuni, Marco, Mussinelli, Roberta, My, Ilaria, Parruti, Giustino, Patti, Giuseppe, Perlini, Stefano, Santilli, Francesca, Signorelli, Carlo, Stefanini, Giulio G., Vergori, Alessandra, Abete, Pasquale, Ageno, Walter, Agostoni, Piergiuseppe, Aiello, Luca, Al Moghazi, Samir, Arboretti, Rosa, Aucella, Filippo, Barbieri, Greta, Barchitta, Martina, Bartoloni, Alessandro, Bonfanti, Paolo, Cacciatore, Francesco, Caiano, Lucia, Carrozzi, Laura, Cascio, Antonio, Castiglione, Giacomo, Cianfrone, Stefania, Ciccullo, Arturo, Cingolani, Antonella, Cipollone, Francesco, Colomba, Claudia, Colombo, Crizia, Cozzi, Ottavia, Crisetti, Annalisa, Crosta, Francesca, Danzi, Gian Battista, D'Ardes, Damiano, de Gaetano Donati, Katleen, Di Gennaro, Francesco, Di Tano, Giuseppe, D'Offizi, Gianpiero, Fusco, Francesco Maria, Gentile, Ivan, Graziani, Emauele, Guarnieri, Gabriella, Larizza, Giovanni, Leone, Armando, Lio, Veronica, Lucia, Mothanje Barbara, Maccagni, Gloria, Madaro, Ferruccio, Maitan, Stefano, Mancarella, Sandro, Manuele, Rosa, Mapelli, Massimo, Maragna, Riccardo, Marcucci, Rossella, Maresca, Giulio, Marongiu, Silvia, Marotta, Claudia, Marra, Lorenzo, Mastroianni, Franco, Mazzitelli, Maria, Mengozzi, Alessandro, Menichetti, Francesco, Meschiari, Marianna, Milic, Jovana, Minutolo, Filippo, Molena, Beatrice, Mussini, Cristina, Musso, Maria, Odone, Anna, Olivieri, Marco, Palimodde, Antonella, Pasi, Emanuela, Pesavento, Raffaele, Petri, Francesco, Pinchera, Biagio, Pivato, Carlo A., Poletti, Venerino, Ravaglia, Claudia, Rossato, Marco, Rossi, Marianna, Sabena, Anna, Salinaro, Francesco, Sangiovanni, Vincenzo, Sanrocco, Carlo, Scoppettuolo, Giancarlo, Scorzolini, Laura, Sgariglia, Raffaella, Simeone, Paola Giustina, Trecarichi, Enrico Maria, Vettor, Roberto, Vianello, Andrea, Vinceti, Marco, Virano, Alexandra, Vocciante, Laura, De Caterina, Raffaele, Iacoviello, Licia

المساهمون: Di Castelnuovo, Augusto, Costanzo, Simona, Antinori, Andrea, Berselli, Nausicaa, Blandi, Lorenzo, Bonaccio, Marialaura, Cauda, Roberto, Gialluisi, Alessandro, Guaraldi, Giovanni, Menicanti, Lorenzo, Mennuni, Marco, Mussinelli, Roberta, My, Ilaria, Parruti, Giustino, Patti, Giuseppe, Perlini, Stefano, Santilli, Francesca, Signorelli, Carlo, Stefanini, Giulio G., Vergori, Alessandra, Abete, Pasquale, Ageno, Walter, Agostoni, Piergiuseppe, Aiello, Luca, Al Moghazi, Samir, Arboretti, Rosa, Aucella, Filippo, Barbieri, Greta, Barchitta, Martina, Bartoloni, Alessandro, Bonfanti, Paolo, Cacciatore, Francesco, Caiano, Lucia, Carrozzi, Laura, Cascio, Antonio, Castiglione, Giacomo, Cianfrone, Stefania, Ciccullo, Arturo, Cingolani, Antonella, Cipollone, Francesco, Colomba, Claudia, Colombo, Crizia, Cozzi, Ottavia, Crisetti, Annalisa, Crosta, Francesca, Danzi, Gian Battista, D'Ardes, Damiano, de Gaetano Donati, Katleen, Di Gennaro, Francesco, Di Tano, Giuseppe, D'Offizi, Gianpiero, Fusco, Francesco Maria, Gentile, Ivan, Graziani, Emauele, Guarnieri, Gabriella, Larizza, Giovanni, Leone, Armando, Lio, Veronica, Lucia, Mothanje Barbara, Maccagni, Gloria, Madaro, Ferruccio, Maitan, Stefano, Mancarella, Sandro, Manuele, Rosa, Mapelli, Massimo, Maragna, Riccardo, Marcucci, Rossella, Maresca, Giulio, Marongiu, Silvia, Marotta, Claudia, Marra, Lorenzo, Mastroianni, Franco, Mazzitelli, Maria, Mengozzi, Alessandro, Menichetti, Francesco, Meschiari, Marianna, Milic, Jovana, Minutolo, Filippo, Molena, Beatrice, Mussini, Cristina, Musso, Maria, Odone, Anna, Olivieri, Marco, Palimodde, Antonella, Pasi, Emanuela, Pesavento, Raffaele, Petri, Francesco, Pinchera, Biagio, Pivato, Carlo A., Poletti, Venerino, Ravaglia, Claudia, Rossato, Marco, Rossi, Marianna, Sabena, Anna, Salinaro, Francesco, Sangiovanni, Vincenzo, Sanrocco, Carlo, Scoppettuolo, Giancarlo, Scorzolini, Laura, Sgariglia, Raffaella

مصطلحات موضوعية: ACE-I, ARB, Angiotensin converting enzyme inhibitor, Angiotensin receptor blocker, Mortality, COVID−19, Sartan, Aged, 80 and over, Angiotensin Receptor Antagonist, Angiotensin-Converting Enzyme Inhibitor, COVID-19, Female, Human, Hypertension, Incidence, Italy, Male, Meta-Analysis as Topic, Middle Aged, Renin-Angiotensin System, Risk Assessment, Risk Factor, Severity of Illness Index, Hospital Mortality, Antihypertensive Agents

الوصف: The hypothesis that been set forward that use of Renin Angiotensin Aldosterone System (RAAS) inhibitors is associated with COVID-19 severity. We set-up a multicenter Italian collaboration (CORIST Project, ClinicalTrials.gov ID: NCT04318418) to retrospectively investigate the relationship between RAAS inhibitors and COVID-19 in-hospital mortality. We also carried out an updated meta-analysis on the relevant studies.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32992048; info:eu-repo/semantics/altIdentifier/wos/WOS:000592523700001; volume:135; numberofpages:10; journal:VASCULAR PHARMACOLOGY; http://hdl.handle.net/10447/471613Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85096814905

الإتاحة: https://doi.org/10.1016/j.vph.2020.106805Test
http://hdl.handle.net/10447/471613Test

المؤلفون: Mantini, Cesare, Di Giammarco, Gabriele, Pizzicannella, Jacopo, Gallina, Sabina, Ricci, Fabrizio, D’Ugo, Emilia, Marchetti, Marziale, Cotroneo, Antonio Raffaele, Ahmed, Nauman, Bucciarelli-Ducci, Chiara, Tartaro, Armando, De Caterina, Raffaele

المساهمون: Mantini, Cesare, Di Giammarco, Gabriele, Pizzicannella, Jacopo, Gallina, Sabina, Ricci, Fabrizio, D’Ugo, Emilia, Marchetti, Marziale, Cotroneo, Antonio Raffaele, Ahmed, Nauman, Bucciarelli-Ducci, Chiara, Tartaro, Armando, De Caterina, Raffaele

مصطلحات موضوعية: Aortic stenosi, Aortic valve area, Cardiac magnetic resonance imaging, Transesophageal echocardiography, Aged, Aortic Valve Stenosi, Echocardiography, Female, Human, Magnetic Resonance Imaging, Male, Preoperative Period, Prospective Studie, Retrospective Studie, Severity of Illness Index, Radiology, Nuclear Medicine and Imaging

الوصف: Aim: To prospectively evaluate the accuracy of cardiac magnetic resonance (cMR) imaging for the assessment of aortic valve effective orifice area (EOA) by continuity equation and anatomical aortic valve area (AVA) by direct planimetry, as compared with transthoracic (TTE) and transesophageal (TEE) two-dimensional (2D) echocardiography, respectively. Methods and results: A total of 31 patients (21 men, 10 women, mean age 69 ± 10 years) with moderate-to-severe aortic stenosis (AS) diagnosed by TTE and scheduled for elective aortic valve replacement, underwent both cMR and TEE. AVA by cMR was obtained from balanced steady-state free-precession cine-images. EOA was computed from phase-contrast MR flow analysis. AVA at cMR (0.93 ± 0.42 cm2) was highly correlated with TEE-derived planimetry (0.92 ± 0.32 cm2) (concordance correlation coefficient, CCC = 0.85). By excluding 11 patients with extensively thickened and heavily calcified cusps, the CCC increased to 0.93. EOA at cMR (0.86 ± 0.30 cm2) showed a strong correlation with TTE-derived EOA (0.78 ± 0.25 cm2) (CCC = 0.82). Conclusions: cMR imaging is an accurate alternative for the grading of AS severity. Its use may be recommended especially in patients with poor transthoracic acoustic windows and/or in case of discordance between 2D echocardiographic parameters. © 2018, Italian Society of Medical Radiology.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29730841; info:eu-repo/semantics/altIdentifier/wos/WOS:000441712500001; volume:123; issue:9; firstpage:643; lastpage:654; numberofpages:12; journal:LA RADIOLOGIA MEDICA; http://hdl.handle.net/11564/696105Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85046462800; http://link.springer.com/journal/11547Test

الإتاحة: https://doi.org/10.1007/s11547-018-0895-2Test
http://hdl.handle.net/11564/696105Test
http://link.springer.com/journal/11547Test

المؤلفون: Madonna, Rosalinda, Renna, Francesca Vera, Lanuti, Paola, Perfetti, Matteo, Marchisio, Marco, Briguori, Carlo, Condorelli, Gerolama, MANZOLI, Lamberto, De Caterina, Raffaele

المساهمون: Madonna, Rosalinda, Renna, Francesca Vera, Lanuti, Paola, Perfetti, Matteo, Marchisio, Marco, Briguori, Carlo, Condorelli, Gerolama, Manzoli, Lamberto, De Caterina, Raffaele

مصطلحات موضوعية: Anticholesteremic Agent, Atorvastatin Calcium, Coronary Artery Disease, Dose-Response Relationship, Drug, Double-Blind Method, Drug Therapy, Combination, Endothelial Progenitor Cell, Ezetimibe, Female, Flow Cytometry, Human, Male, Middle Aged, Rosuvastatin Calcium

الوصف: Rationale and objectiveEndothelial progenitor cells (EPCs) play a role in vascular repair, while circulating endothelial cells (CECs) are biomarkers of vascular damage and regeneration. Statins may promote EPC/CEC mobilization in the peripheral blood. We evaluated whether pre-procedural exposure to different lipid-lowering drugs (statins +/- ezetimibe) can acutely increase levels/activity of EPCs/CECs in patients with stable coronary artery disease (CAD).MethodsIn a planned sub-analysis of the Rosuvastatin For REduction Of Myocardial DamagE During Coronary AngioplastY (REMEDY) trial, 38 patients with stable CAD on chronic low-dose statin therapy were randomized, in a double-blind, placebo-controlled design, into 4 groups before PCI: i. placebo (n = 11); ii. atorvastatin (80 mg+40 mg, n = 9); iii. rosuvastatin (40 mg twice, n = 9); and iv. rosuvastatin (5 mg) and ezetimibe (10 mg) twice, (n = 9). At baseline and 24 h after treatment-before PCI-, patients underwent blinded analyses of EPCs [colony forming units-endothelial cells (CFU-ECs), endothelial colony-forming cells (ECFCs) and tubulization activity] and CECs in peripheral blood.ResultsWe found no significant treatment effects on parameters investigated such as number of CECs [Median (IQR): i. 0(0), ii. 4.5(27), iii. 1.9(2.3), iv. 1.9(2.3)], CFU-ECs [Median (IQR): i. 27(11), ii. 19(31), iii. 47(36), iv. 30(98)], and ECFCs [Median (IQR): i. 86(84), ii. 7(84), iii. 8/(42.5), iv. 5(2)], as well as tubulization activity [total tubuli (well), Median (IQR): i. 19(7), ii. 5(4), iii. 25(13), iv. 15(24)].ConclusionsIn this study, we found no evidence of acute changes in levels or activity of EPCs and CECs after high-dose lipid-lowering therapy in stable CAD patients.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28394933; info:eu-repo/semantics/altIdentifier/wos/WOS:000399954800001; volume:12; issue:4; firstpage:e0172800-1; lastpage:e0172800-18; numberofpages:18; journal:PLOS ONE; http://hdl.handle.net/11392/2368144Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85017222214; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172800&type=printableTest; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172800Test

الإتاحة: https://doi.org/10.1371/journal.pone.0172800Test
http://hdl.handle.net/11392/2368144Test
http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172800&type=printableTest
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172800Test

المؤلفون: Parollo, Matteo, Levantino, Maurizio, Pucci, Angela, Aquaro, Giovanni Donato, Delle Donne, Maria Grazia, Caravelli, Paolo, Capozza, Paola, Colli, Andrea, De Caterina, Raffaele

المساهمون: Parollo, Matteo, Levantino, Maurizio, Pucci, Angela, Aquaro, Giovanni Donato, Delle Donne, Maria Grazia, Caravelli, Paolo, Capozza, Paola, Colli, Andrea, De Caterina, Raffaele

مصطلحات موضوعية: Human, Magnetic Resonance Imaging, Crohn Disease, Heart Neoplasm, Myxoma, Thrombosis

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35287159; info:eu-repo/semantics/altIdentifier/wos/WOS:000768561900009; volume:23; issue:4; firstpage:272; lastpage:274; numberofpages:3; journal:JOURNAL OF CARDIOVASCULAR MEDICINE; https://hdl.handle.net/11568/1156214Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85126697603

الإتاحة: https://doi.org/10.2459/JCM.0000000000001301Test
https://hdl.handle.net/11568/1156214Test

المؤلفون: Montinari, Maria Rosa, Minelli, Sergio, De Caterina, Raffaele

المساهمون: Montinari, Maria Rosa, Minelli, Sergio, De Caterina, Raffaele

مصطلحات موضوعية: History of medicine, Non-vitamin K antagonist oral anticoagulants: NOAC, Oral anticoagulant, Thromboembolism, VKA, Vitamin K antagonist, Administration, Oral, Anticoagulant, Hemorrhage, Human, Vitamin K, Atrial Fibrillation, Stroke

الوصف: In the year 2021 we celebrate the 80th anniversary of the first clinical use of vitamin K antagonists (VKAs), the mainstay of prevention and long-term treatment of thromboembolic disease. The discovery and development of oral anticoagulants is one of the most important chapters in the history of medicine, a goal pursued by physicians trying to combat the clinical manifestations of thrombosis since ancient times. Until the last decade, VKAs were the only oral anticoagulants available and used in clinical practice. Today, their clinical use has progressively shrunk, as the non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly replacing VKAs in various conditions after the successful completion of several large randomized controlled trials. Currently, new research is tackling upstream components of the intrinsic pathway - particularly factor XI and factor XII - for the development of new, even safer anticoagulants promising to reduce bleeding without compromising efficacy. This review highlights the evolution of oral anticoagulant therapy tracing the key stages of a long and fascinating history that has unfolded from the first part of the twentieth century until today, indeed an intriguing journey where serendipity is intertwined with the tenacious work of many researchers.

وصف الملف: STAMPA

العلاقة: volume:141; firstpage:106918; journal:VASCULAR PHARMACOLOGY; http://hdl.handle.net/11587/467972Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85115422631

الإتاحة: https://doi.org/10.1016/j.vph.2021.106918Test
http://hdl.handle.net/11587/467972Test

المؤلفون: Di Castelnuovo, Augusto, Gialluisi, Alessandro, Antinori, Andrea, Berselli, Nausicaa, Blandi, Lorenzo, Bonaccio, Marialaura, Bruno, Raffaele, Cauda, Roberto, Costanzo, Simona, Guaraldi, Giovanni, Menicanti, Lorenzo, Mennuni, Marco, My, Ilaria, Parruti, Giustino, Patti, Giuseppe, Perlini, Stefano, Santilli, Francesca, Signorelli, Carlo, Stefanini, Giulio, Vergori, Alessandra, Ageno, Walter, Agodi, Antonella, Agostoni, Piergiuseppe, Aiello, Luca, Al Moghazi, Samir, Arboretti, Rosa, Aucella, Filippo, Barbieri, Greta, Barchitta, Martina, Bonfanti, Paolo, Cacciatore, Francesco, Caiano, Lucia, Cannata, Francesco, Carrozzi, Laura, Cascio, Antonio, Castiglione, Giacomo, Ciccullo, Arturo, Cingolani, Antonella, Cipollone, Francesco, Colomba, Claudia, Colombo, Crizia, Crisetti, Annalisa, Crosta, Francesca, Danzi, Gian Battista, D'Ardes, Damiano, de Gaetano Donati, Katleen, Di Gennaro, Francesco, Di Tano, Giuseppe, D'Offizi, Gianpiero, Fusco, Francesco Maria, Gaudiosi, Carlo, Gentile, Ivan, Gianfagna, Francesco, Giuliano, Gabriele, Graziani, Emauele, Guarnieri, Gabriella, Langella, Valerio, Larizza, Giovanni, Leone, Armando, Maccagni, Gloria, Magni, Federica, Maitan, Stefano, Mancarella, Sandro, Manuele, Rosa, Mapelli, Massimo, Maragna, Riccardo, Marcucci, Rossella, Maresca, Giulio, Marongiu, Silvia, Marotta, Claudia, Marra, Lorenzo, Mastroianni, Franco, Mengozzi, Alessandro, Meschiari, Marianna, Milic, Jovana, Minutolo, Filippo, Mussinelli, Roberta, Mussini, Cristina, Musso, Maria, Odone, Anna, Olivieri, Marco, Palimodde, Antonella, Pasi, Emanuela, Pesavento, Raffaele, Petri, Francesco, Pivato, Carlo A, Poletti, Venerino, Ravaglia, Claudia, Righetti, Giulia, Rognoni, Andrea, Rossato, Marco, Rossi, Ilaria, Rossi, Marianna, Sabena, Anna, Salinaro, Francesco, Sangiovanni, Vincenzo, Sanrocco, Carlo, Schiano Moriello, Nicola, Scorzolini, Laura, Sgariglia, Raffaella, Simeone, Paola Giustina, Spinicci, Michele, Tamburrini, Enrica, Torti, Carlo, Trecarichi, Enrico Maria, Vettor, Roberto, Vianello, Andrea, Vinceti, Marco, Virdis, Agostino, De Caterina, Raffaele, Iacoviello, Licia

المساهمون: Di Castelnuovo, Augusto, Gialluisi, Alessandro, Antinori, Andrea, Berselli, Nausicaa, Blandi, Lorenzo, Bonaccio, Marialaura, Bruno, Raffaele, Cauda, Roberto, Costanzo, Simona, Guaraldi, Giovanni, Menicanti, Lorenzo, Mennuni, Marco, My, Ilaria, Parruti, Giustino, Patti, Giuseppe, Perlini, Stefano, Santilli, Francesca, Signorelli, Carlo, Stefanini, Giulio, Vergori, Alessandra, Ageno, Walter, Agodi, Antonella, Agostoni, Piergiuseppe, Aiello, Luca, Al Moghazi, Samir, Arboretti, Rosa, Aucella, Filippo, Barbieri, Greta, Barchitta, Martina, Bonfanti, Paolo, Cacciatore, Francesco, Caiano, Lucia, Cannata, Francesco, Carrozzi, Laura, Cascio, Antonio, Castiglione, Giacomo, Ciccullo, Arturo, Cingolani, Antonella, Cipollone, Francesco, Colomba, Claudia, Colombo, Crizia, Crisetti, Annalisa, Crosta, Francesca, Danzi, Gian Battista, D'Ardes, Damiano, de Gaetano Donati, Katleen, Di Gennaro, Francesco, Di Tano, Giuseppe, D'Offizi, Gianpiero, Fusco, Francesco Maria, Gaudiosi, Carlo, Gentile, Ivan, Gianfagna, Francesco, Giuliano, Gabriele, Graziani, Emauele, Guarnieri, Gabriella, Langella, Valerio, Larizza, Giovanni, Leone, Armando, Maccagni, Gloria, Magni, Federica, Maitan, Stefano, Mancarella, Sandro, Manuele, Rosa, Mapelli, Massimo, Maragna, Riccardo, Marcucci, Rossella, Maresca, Giulio, Marongiu, Silvia, Marotta, Claudia, Marra, Lorenzo, Mastroianni, Franco, Mengozzi, Alessandro, Meschiari, Marianna, Milic, Jovana, Minutolo, Filippo, Mussinelli, Roberta, Mussini, Cristina, Musso, Maria, Odone, Anna, Olivieri, Marco, Palimodde, Antonella, Pasi, Emanuela, Pesavento, Raffaele, Petri, Francesco, Pivato, Carlo A, Poletti, Venerino, Ravaglia, Claudia, Righetti, Giulia, Rognoni, Andrea, Rossato, Marco, Rossi, Ilaria, Rossi, Marianna, Sabena, Anna, Salinaro, Francesco, Sangiovanni, Vincenzo, Sanrocco, Carlo, Schiano Moriello, Nicola, Scorzolini, Laura, Sgariglia, Raffaella

مصطلحات موضوعية: Aged, 80 and over, Antimalarial, COVID-19, Cluster Analysi, Female, Human, Hydroxychloroquine, Italy, Male, Middle Aged, Retrospective Studie, SARS-CoV-2, Severity of Illness Index, Treatment Outcome, Hospital Mortality

الوصف: The efficacy of hydroxychloroquine (HCQ) in treating SARS-CoV-2 infection is harshly debated, with observational and experimental studies reporting contrasting results. To clarify the role of HCQ in Covid-19 patients, we carried out a retrospective observational study of 4,396 unselected patients hospitalized for Covid-19 in Italy (February-May 2020). Patients' characteristics were collected at entry, including age, sex, obesity, smoking status, blood parameters, history of diabetes, cancer, cardiovascular and chronic pulmonary diseases, and medications in use. These were used to identify subtypes of patients with similar characteristics through hierarchical clustering based on Gower distance. Using multivariable Cox regressions, these clusters were then tested for association with mortality and modification of effect by treatment with HCQ. We identified two clusters, one of 3,913 younger patients with lower circulating inflammation levels and better renal function, and one of 483 generally older and more comorbid subjects, more prevalently men and smokers. The latter group was at increased death risk adjusted by HCQ (HR[CI95%] = 3.80[3.08-4.67]), while HCQ showed an independent inverse association (0.51[0.43-0.61]), as well as a significant influence of cluster*HCQ interaction (p<0.001). This was driven by a differential association of HCQ with mortality between the high (0.89[0.65-1.22]) and the low risk cluster (0.46[0.39-0.54]). These effects survived adjustments for additional medications in use and were concordant with associations with disease severity and outcome. These findings suggest a particularly beneficial effect of HCQ within low risk Covid-19 patients and may contribute to clarifying the current controversy on HCQ efficacy in Covid-19 treatment.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34336157; info:eu-repo/semantics/altIdentifier/wos/WOS:000671869900002; volume:2021; firstpage:5556207; lastpage:5556210; numberofpages:4; journal:JOURNAL OF HEALTHCARE ENGINEERING; https://hdl.handle.net/11383/2143192Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85110514370

الإتاحة: https://doi.org/10.1155/2021/5556207Test
https://hdl.handle.net/11383/2143192Test

المؤلفون: Montinari, Maria Rosa, Minelli, Sergio, De Caterina, Raffaele

المساهمون: Montinari, Maria Rosa, Minelli, Sergio, De Caterina, Raffaele

مصطلحات موضوعية: Acetylsalicylic acid, Antiplatelet agent, Aspirin, Cardiovascular disease, History of medicine, Animal, Anti-Inflammatory Agents, Non-Steroidal, Antipyretic, Cardiovascular Agent, History, Ancient, Human, Plant Bark, Plant Leave, Platelet Aggregation Inhibitor, Salix

الوقت: 18th Century, 19th Century, 20th Century, 21st Century

الوصف: Aspirin is currently the most widely used drug worldwide, and has been clearly one of the most important pharmacological achievements of the twentieth century. Historians of medicine have traced its birth in 1897, but the fascinating history of aspirin actually dates back >3500 years, when willow bark was used as a painkiller and antipyretic by Sumerians and Egyptians, and then by great physicians from ancient Greece and Rome. The modern history of aspirin precursors, salicylates, began in 1763 with Reverend Stone - who first described their antipyretic effects - and continued in the 19th century with many researchers involved in their extraction and chemical synthesis. Bayer chemist Felix Hoffmann synthesized aspirin in 1897, and 70 years later the pharmacologist John Vane elucidated its mechanism of action in inhibiting prostaglandin production. Originally used as an antipyretic and anti-inflammatory drug, aspirin then became, for its antiplatelet properties, a milestone in preventing cardiovascular and cerebrovascular diseases. The aspirin story continues today with the growing evidence of its chemopreventive effect against colorectal and other types of cancer, now awaiting the results of ongoing primary prevention trials in this setting. This concise review revisits the history of aspirin with a focus on its most remote origins.

وصف الملف: STAMPA

العلاقة: volume:113; firstpage:1; lastpage:8; journal:VASCULAR PHARMACOLOGY; http://hdl.handle.net/11587/470266Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85056824151

الإتاحة: https://doi.org/10.1016/j.vph.2018.10.008Test
http://hdl.handle.net/11587/470266Test

المؤلفون: Todiere, Giancarlo, Nugara, Cinzia, Gentile, Giovanni, Negri, Francesco, Bianco, Francesco, Falletta, Calogero, Novo, Giuseppina, Di Bella, Gianluca, De Caterina, Raffaele, Zachara, Elisabetta, Re, Federica, Clemenza, Francesco, Sinagra, Gianfranco, Emdin, Michele, Aquaro, Giovanni Donato

المساهمون: Todiere, Giancarlo, Nugara, Cinzia, Gentile, Giovanni, Negri, Francesco, Bianco, Francesco, Falletta, Calogero, Novo, Giuseppina, Di Bella, Gianluca, De Caterina, Raffaele, Zachara, Elisabetta, Re, Federica, Clemenza, Francesco, Sinagra, Gianfranco, Emdin, Michele, Aquaro, Giovanni Donato

مصطلحات موضوعية: Cardiomyopathy, Hypertrophic, Contrast Media, Death, Sudden, Cardiac, Female, Follow-Up Studie, Gadolinium, Heart Ventricle, Human, Incidence, Italy, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Myocardium, Prognosi, ROC Curve, Retrospective Studie, Risk Assessment, Risk Factor, Survival Rate, Ventricular Function, Left

الوصف: Sudden cardiac death (SCD) is the most life-threating complication of hypertrophic cardiomyopathy. Guidelines of the European Society of Cardiology (ESC) suggest the implantation of an implantable cardioverter defibrillator in primary prevention according to a 5-year risk SCD score >= 6%. The aim of the study is to evaluate the prognostic role of late gadolinium enhancement (LGE) in patients with a 5-year risk SCD score <6%. In this multicenter study, we performed cardiac magnetic resonance in 354 consecutive hypertrophic cardiomy-opathy patients (257 males, range of age 54 +/- 17) with a risk SCD score <6% (302 with <4% and 52 with >= 4 and <6% risk). Hard cardiac events, including SCD, resuscitated cardiac arrest, appropriate implantable cardioverter defibrillator interventions, sustained ventricular tachycardia, occurred in 22 patients. LGE was detected in a high proportion (92%) of patients with hard cardiac events (p = 0.002). At receiver-operating characteristic curve analysis, LGE extent >= 10% was the best threshold to predict major arrhythmic events (area under the curve: 0.74). Kaplan-Meier curves showed that patients with LGE >= 10% had a worse prognosis than those with lower extent (p < 0.0001). LGE extent was the best independent predictor of hard cardiac events (hazard ratio 1.05; 95% confidence interval [CI] 1.03 to 107; p < 0.0001). The estimates 5-year risk of hard cardiac event was 2.5% (95% CI 0.8 to 4.2) in patients with LGE extent <10% and 23.4% (95% CI 10.2 to 36.5) for those with LGE extent >= 10%. In conclusion, this study demonstrates as the extent of LGE >= 10% is able to recognize additional patients at increased risk for malignant arrhythmic episodes in a population with low-to-intermediate ESC SCD risk score. (C) 2019 Elsevier Inc. All rights reserved.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31447011; info:eu-repo/semantics/altIdentifier/wos/WOS:000491215600019; volume:124; issue:8; firstpage:1286; lastpage:1292; numberofpages:7; journal:THE AMERICAN JOURNAL OF CARDIOLOGY; https://hdl.handle.net/11568/1156225Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85070893303

الإتاحة: https://doi.org/10.1016/j.amjcard.2019.07.023Test
https://hdl.handle.net/11568/1156225Test