التفاصيل البيبلوغرافية
| العنوان: |
Using CD4 percentage and age to optimize pediatric antiretroviral therapy initiation |
| المؤلفون: |
D. E. Yin, M. G. Warshaw, W. C. Miller, H. Castro, S. A. Fiscus, L. M. Harper, L. J. Harrison, N. J. Klein, J. Lewis, A. J. Melvin, G. Tudor Williams, R. E. Mckinney, Brouwers P, Costello D, Ferguson E, Fiscus S, Hodge J, Hughes M, Jennings C, Melvin A, McKinney R, Mofenson L, Warshaw M, Smith ME, Spector S, Stiehm E, Toye M, Yogev R, Babiker A, Castro H, Compagnucci A, De Rossi A, Giaquinto C, Darbyshire J, Debré M, Gibb DM, Harper L, Harrison L, Klein N, Pillay D, Saidi Y, Tudor Williams G, Walker AS, Brody B, Hill C, Lepage P, Modlin J, Poziak A, Rein M, Robb M, Fleming T, Vella S, Kim KM, Bologna R, Mecikovsky D, Pineda N, Sen L, Mangano A, Marino S, Galvez C, Deluchi G, Zöhrer B, Zenz W, Daghofer E, Pfurtscheller K, Pabst B, Gomez MP, McNeil P, Jervis M, Whyms I, Kwolfe D, Scott S, Mussi Pinhata MM, Issac ML, Cervi MC, Negrini BV, Matsubara TC, de Souza CB, Gabaldi JC, Oliveira RH, Sapia MC, Abreu T, Evangelista L, Pala A, Fernandes I, Farias I, de F. Melo M, Carreira H, Lira LM, Della Negra M, Queiroz W, Lian YC, Pacola DP, Pinto J, Ferreira F, Kakehasi F, Martins L, Diniz A, Lobato V, Diniz M, Cleto S, Costa S, Romeiro J, Dollfus C, Tabone MD, Courcoux MF, Vaudre G, Dehée A, Schnuriger A, Le Gueyades N, De Bortoli C, Méchinaud F, Reliquet V, Arias J, Rodallec A, André E, Falconi I, Le Pelletier A, Monpoux F, Cottalorda J, Mellul S, Lachassinne E, Galimand J, Rouzioux C, Chaix ML, Benabadji Z, Pourrat M, Firtion G, Rivaux D, Denon M, Boudjoudi N, Nganzali F, Krivine A, Méritet JF, Delommois G, Norgeux C, Guérin C, Floch C, Marty L, Hichou H, Tournier V, Faye A, Le Moal I, Sellier M, Dehache L, Damond F, Leleu J, Beniken D, Alexandre Castor G, Neubert J, Niehues T, Laws HJ, Huck K, Gudowius S, Siepermann K, Loeffler H, Bellert S, Ortwin A, Notheis G, Wintergerst U, Hoffman F, Werthmann A, Seyboldt S, Schneider L, Bucholz B, Feiterna Sperling C, Peiser C, Nickel R, Schmitz T, Piening T, Müller C, Warncke G, Wigger M, Neubauer R, Butler K, Chong AL, Boulger T, Menon A, O'Connell M, Barrett L, Rochford A, Goode M, Hayes E, McDonagh S, Walsh A, Doyle A, Fanning J, O'Connor M, Byrne M, O'Sullivan N, Hyland E, Giacomet V, Viganò A, Colombo I, Berzi A, Badolato R, Schumacher F, Bennato V, Brusati M, Sorlini A, Spinelli E, Filisetti M, Bertulli C, Rampon O, Zanchetta M, Mazza A, Stringari G, Rossetti G, Bernardi S, Martino A, Castelli Gattinara G, Palma P, Pontrelli G, Tchidjou H, Furcas A, Frillici C, Mazzei A, Zoccano A, Concato C, Duiculescu D, Oprea C, Tardei G, Abaab F, Mardarescu M, Draghicenoiu R, Otelea D, Alecsandru L, Matusa R, Rugina S, Ilie M, Netescu S, Florea C, Voicu E, Poalelungi D, Belmega C, Vladau L, Chiriac A, Ramos Amador JT, Gonzalez Tomé MI, Rojo Conejo P, Fernandez M, Delgado Garcia R, Ferrari JM, Garcia Lopez M, Mellado Peña MJ, Martin Fontelos P, Jimenez Nacher I, Muñoz Fernandez MA, Jimenez JL, García Torre A, Penin M, Pineiro Perez R, Garcia Mellado I, Finn A, LaJeunesse M, Hutchison E, Usher J, Ball L, Dunn M, Sharland M, Doerholt K, Storey S, Donaghy S, Chakraborty R, Wells C, Buckberry K, Rice P, McMaster P, Butler P, R. O'Connell C, Shenton J, Haley H, Orendi J, Stroobant J, Navarante L, Archer P, Mazhude C, Scott D, O'Connell R, Wong J, Boddy G, Shackley F, Lakshman R, Hobbs J, Ball G, Kudesia G, Bane J, Painter D, Sloper K, Shah V, Cheng A, Aali A, Ball C, Hawkins S, Nayagam D, Waters A, Doshi S, Liebeschuetz S, Sodiende B, Shingadia D, Wong S, Swan J, Shah Z, Collinson A, Hayes C, King J, O'Connor K, Lyall H, Fidler K, Walters S, Foster C, Hamadache D, Newbould C, Monrose C, Campbell S, Yeung S, Cohen J, Martinez Allier N, Melvin D, Dodge J, Welch S, Tatum G, Gordon A, Kaye S, Muir D, Patel D, Novelli V, Gibb D, Moshal K, Lambert J, Flynn J, Farrelly L, Clapson M, Spencer L, Depala M, Jacobsen M, Segal S, Pollard A, Kelly D, Yeadon S, Ohene Kena B, Peng Y, Dong T, Jeffries K, Snelling M, Smyth A, Smith J, Ward B, Jungmann E, Ryan C, Swaby K, Buckton A, Smit E, Abrams EJ, Champion S, Fernandez AD, Calo D, Garrovillo L, Swaminathan K, Alford T, Frere M, Navarra J, Borkowsky W, Deygoo S, Hastings T, Akleh S, Ilmet T, Mohan K, Bowen G, Emmanuel PJ, Lujan Zimmerman J, Rodriguez C, Johnson S, Marion A, Graisbery C, Casey D, Lewis G, Guzman Cottrill J, Croteau R, Acevedo Flores M, Gonzalez M, Angeli L, Fabregas L, Valentin P, Weiner L, Contello KA, Holz W, Butler M, Nachman S, Kelly MA, Ferraro DM, Rana S, Reed C, Yeagley E, Malheiro A, Roa J, Neely M, Kovacs A, Homans J, Rodriguez Lozano Y, Puga A, Talero G, Sellers R, Lawrence R, Weinberg GA, Murante B, Laverty S, Deveikis A, Batra J, Chen T, Michalik D, Deville J, Elkins K, Marks S, Jackson Alvarez J, Palm J, Fineanganofo I, Keuth M, Deveikis L, Tomosada W, Van Dyke R, Alchediak T, Silio M, Borne C, Bradford S, Eloby Childress S, Nguyen K, Rathore MH, Alvarez A, Mirza A, Mahmoudi S, Burke M, Febo IL, Lugo L, Santos R, Church JA, Dunaway T, Rodier C, Flynn P, Patel N, DiScenza S, Donohoe M, Luzuriaga K, Picard D, Kline M, Paul ME, Shearer WT, McMullen C, Chadwick E, Cagwin E, Kabat K, Dieudonne A, Palumbo P, Johnson J, Gaur S, Cerracchio L, Foca M, Jurgrau A, Vasquez Bonilla S, Silva G, Gershon A, Sullivan J, Bryson Y, Frenkel L, Nelson J, Aboulker JP, Hadjou G, Léonardo S, Riault Y, Saïdi Y, Buck L, Darbyshire JH, Forcat S, Horton J, Johnson D, Moore S, Taylor C, Collins D, Buskirk S, Kamara P, Nesel C, Johnson M, Ferreira A, Tutko J, Sprenger H, Britto P, Powell C, DerSimonian R, Handelsman E, Ananworanich J, Belfrage E, Blanche S, Bohlin AB, Burger D, Clayden P, De Groot R, Di Biagio A, Grosch Wörner I, Hainault M, Lallemant M, Levy J, Marczynska M, Mellado Pena MJ, Nadal D, Naver L, Peckham C, Popieska J, Rosado L, Rosso R, Rudin C, Scherpbier H, Stevanovic M, Thorne C, Tovo PA, Valerius N, Poole C, Cole SR, McCulloh R.J., Trabattoni D |
| المساهمون: |
D.E. Yin, M.G. Warshaw, W.C. Miller, H. Castro, S.A. Fiscu, L.M. Harper, L.J. Harrison, N.J. Klein, J. Lewi, A.J. Melvin, G. Tudor-William, R.E. Mckinney, Brouwers P, Costello D, Ferguson E, Fiscus S, Hodge J, Hughes M, Jennings C, Melvin A, McKinney R, Mofenson L, Warshaw M, Smith ME, Spector S, Stiehm E, Toye M, Yogev R, Babiker A, Castro H, Compagnucci A, De Rossi A, Giaquinto C, Darbyshire J, Debré M, Gibb DM, Harper L, Harrison L, Klein N, Pillay D, Saidi Y, Tudor-Williams G, Walker AS, Brody B, Hill C, Lepage P, Modlin J, Poziak A, Rein M, Robb M, Fleming T, Vella S, Kim KM, Bologna R, Mecikovsky D, Pineda N, Sen L, Mangano A, Marino S, Galvez C, Deluchi G, Zöhrer B, Zenz W, Daghofer E, Pfurtscheller K, Pabst B, Gomez MP, McNeil P, Jervis M, Whyms I, Kwolfe D, Scott S, Mussi-Pinhata MM, Issac ML, Cervi MC, Negrini BV, Matsubara TC, de Souza CB, Gabaldi JC, Oliveira RH, Sapia MC, Abreu T, Evangelista L, Pala A, Fernandes I, Farias I, de F Melo M, Carreira H, Lira LM, Della Negra M, Queiroz W, Lian YC, Pacola DP, Pinto J, Ferreira F, Kakehasi F, Martins L, Diniz A, Lobato V, Diniz M |
| بيانات النشر: |
American Academy of Pediatrics |
| سنة النشر: |
2014 |
| المجموعة: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: |
Child, HIV, Immunologic, Reconstitution, Treatment failure, Adolescent, Anti-HIV Agent, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-Positive T-Lymphocyte, Preschool, Female, Follow-Up Studie, HIV Infection, HIV-1, Human, Infant, Newborn, Male, Pediatrics, Perinatology and Child Health, Settore MED/04 - Patologia Generale, Settore MED/17 - Malattie Infettive, Settore BIO/13 - Biologia Applicata, Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio |
| الوصف: |
BACKGROUND: Quantifying pediatric immunologic recovery by highly active antiretroviral therapy (HAART) initiation at different CD4 percentage (CD4%) and age thresholds may inform decisions about timing of treatment initiation. METHODS: HIV-1-infected, HAART-naive children in Europe and the Americas were followed from 2002 through 2009 in PENPACT-1. Data from 162 vertically infected children, with at least World Health Organization "mild" immunosuppression and CD4% <10th percentile, were analyzed for improvement to a normal CD4% (≥10th percentile) within 4 years after HAART initiation. Data from 209 vertically infected children, regardless of immune status, were analyzed for CD4% outcomes at 4 years and viral failure within 4 years. RESULTS: Seventy-two percent of baseline immunosuppressed children recovered to normal within 4 years. Compared with "severe" immunosuppression, more children with "mild" immunosuppression (difference 36%, 95% confidence interval [CI]: 22% to 49%) or "advanced" immunosuppression (difference 20.8%, 95% CI: 5.8% to 35.9%) recovered a normal CD4%. For each 5-year increase in baseline age, the proportion of children achieving a normal CD4% declined by 19% (95% CI: 11% to 27%). Combining baseline CD4% and age effects resulted in .90% recovery when initiating HAART with "mild" immunosuppression at any age or "advanced" immunosuppression at age ,3 years. Baseline CD4% effects became greater with increasing age (P = .02). At 4 years, most immunologic benefits were still significant but diminished. Viral failure was highest in infancy (56%) and adolescence (63%). CONCLUSIONS: Initiating HAART at higher CD4% and younger ages maximizes potential for immunologic recovery. Guidelines should weigh immunologic benefits against long-term risks. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/25266426; info:eu-repo/semantics/altIdentifier/wos/WOS:000343140500022; volume:134; issue:4; firstpage:e1104; lastpage:e1116; journal:PEDIATRICS; http://hdl.handle.net/2434/477762Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84989162261; http://pediatrics.aappublications.org/content/pediatrics/134/4/e1104.full.pdfTest |
| DOI: |
10.1542/peds.2014-0527 |
| الإتاحة: |
https://doi.org/10.1542/peds.2014-0527Test
http://hdl.handle.net/2434/477762Test
http://pediatrics.aappublications.org/content/pediatrics/134/4/e1104.full.pdfTest |
| رقم الانضمام: |
edsbas.1CCFD3EC |
| قاعدة البيانات: |
BASE |
