دورية أكاديمية
Oral glucose effectiveness and metabolic risk in obese children and adolescents
| العنوان: | Oral glucose effectiveness and metabolic risk in obese children and adolescents |
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| المؤلفون: | Spreghini N., Cianfarani S., Spreghini M. R., Brufani C., Morino G. S., Inzaghi E., Convertino A., Fintini D., Manco M. |
| المساهمون: | Spreghini, N, Cianfarani, S, Spreghini, Mr, Brufani, C, Morino, G, Inzaghi, E, Convertino, A, Fintini, D, Manco, M |
| بيانات النشر: | Springer-Verlag Italia s.r.l. |
| سنة النشر: | 2019 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Glucose effectivene, Glucose metabolism, Metabolic syndrome, Adolescent, Blood Glucose, Child, Female, Glucose Tolerance Test, Human, Insulin, Male, Obesity, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA |
| الوصف: | Aim: To investigate whether GE is affected in children/adolescents with obesity and abnormalities of the metabolic syndrome (MetS). Methods: Cross-sectional study of oral GE (oGE), insulin sensitivity and secretion (calculated on 5 time-points oral glucose tolerance test) and metabolic abnormalities in 1012 patients with overweight/obesity (aged 6.0–17.9 years old). A MetS risk score was calculated on the basis of distribution of fasting glucose, triglycerides, HDL-cholesterol, total cholesterol, systolic and diastolic blood pressure. Non-alcoholic fatty liver disease (NAFLD) was suspected based on thresholds of alanine aminotransferases. Results: Four-hundred and eighty patients (47.73%) had low-MetS risk score, 488 medium (48.22% with 1–2 risk factors) and 41 (4.05% with ≥ 3 factors) high risk. oGE was significantly lower in subjects with obesity [3.81 (1.46) mg/dl/min − 1 ] than in those with overweight [4.98 (1.66) mg/dl/min − 1 ; p value < 0.001]. oGE was negatively correlated with BMI (ρ = − 0.79; p < 0.001) and BMI z score (ρ = − 0.56; p < 0.001) and decreased significantly among MetS risk classes (p = 0.001). The median difference of oGE from low to medium risk was estimated to be as − 4.9%, from medium to high as − 13.38% and from low to high as − 17.62%. oGE was not statistically different between NAFLD+ and NAFLD− cases. Conclusions: In children and adolescents with obesity oGE decreases. Noteworthy, it decreases as the Met score increases. Therefore, reduced oGE may contribute to the higher risk of these individuals to develop type 2 diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30868315; info:eu-repo/semantics/altIdentifier/wos/WOS:000473127700014; volume:56; issue:8; firstpage:955-962; lastpage:962; journal:ACTA DIABETOLOGICA; http://hdl.handle.net/2108/232145Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85062922652; link.springer.de/link/service/journals/00592/index.htm |
| DOI: | 10.1007/s00592-019-01303-y |
| الإتاحة: | https://doi.org/10.1007/s00592-019-01303-yTest http://hdl.handle.net/2108/232145Test |
| رقم الانضمام: | edsbas.4C9A0958 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00592-019-01303-y |
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