التفاصيل البيبلوغرافية
| العنوان: |
A Viral RNA Structural Element Alters Host Recognition of Nonself RNA. |
| المؤلفون: |
Hyde, Jennifer L.1, Gardner, Christina L.2, Taishi Kimura3, White, James P.1, Gai Liu4, Trobaugh, Derek W.2, Cheng Huang5, Tonelli, Marco6, Paessler, Slobodan5, Kiyoshi Takeda3, Klimstra, William B.2, Amarasinghe, Gaya K.4, Diamond, Michael S.1,4,7 diamond@borcim.wustl.edu |
| المصدر: |
Science. 2/14/2014, Vol. 343 Issue 6172, p783-787. 5p. |
| مصطلحات موضوعية: |
*HOST-virus relationships, *ALPHAVIRUSES, *INTERFERONS, *IR genes, *MOLECULAR structure of RNA, *VIRAL genetics, *MOLECULAR immune response |
| مستخلص: |
The article discusses research that shows how pathogenic alphaviruses use secondary structural motifs within the 5' untranslated region (UTR) of their RNA to alter an interferon- (IFN)-stimulated gene that regulates protein synthesis, called lfit1. Topics include how interferon (IFN) signaling limits viral infection, how pathogenic viruses overcome this host response, and viruses' use of RNA structural motifs to avoid immune restriction. |
| قاعدة البيانات: |
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